Protein Alignment Adra2a and Oamb

DIOPT Version :9

• Sequence 1: NP_031443.4
• Gene: Adra2a / 11551
• MGIID: 87934
• Length: 465
• Species: Mus musculus
• Sequence 2: NP_001262774.1
• Gene: Oamb / 43982
• FlyBaseID: FBgn0024944
• Length: 751
• Species: Drosophila melanogaster
• Alignment Length: 584
• Identity: 159/584 - (27%)
• Similarity: 234/584 - (40%)
• Gaps: 191/584 - (32%)

Mouse    51 LVCLAGL--LMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGY 113
            |:.||.|  :.:..:.||.|||.|||.|..|::..|.|:|:||.||:||...|:|||...||...
  Fly    21 LISLAVLEFINVLVIGGNCLVIAAVFCSNKLRSVTNFFIVNLAVADLLVGLAVLPFSATWEVFKV 85

Mouse   114 WYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAV 178
            |.||.:||.|:||:||..||:||::|||||||||.::|:.:.|....:.::.|::|..:||:|..
  Fly    86 WIFGDLWCRIWLAVDVWMCTASILNLCAISLDRYVAVTRPVTYPSIMSTKKAKSLIAGIWVLSFF 150

Mouse   179 ISFPPLI-------------------------------------SIEKKGA------------GG 194
            |.||||:                                     ||:.:|.            |.
  Fly   151 ICFPPLVGWKDQKAVIQPTYPKGNHTLYYTTTMSSSEDGQLGLDSIKDQGEASLPPSPPHIGNGN 215

Mouse   195 GQQPAEP---------------------------------------------------------- 201
            ...|.:|
  Fly   216 AYNPYDPGFAPIDGSAEIRIAAIDSTSTSTTATTTTTASSSSTTETEMDLDLLNAPPQNRPQTIS 280

Mouse   202 -----SCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGA 261
                 .|::.:.:.||:.|::|||:.|..:|:..|.|||:.|.|.||.  ..:|........|..
  Fly   281 GSCPWKCELTNDRGYVLYSALGSFYIPMFVMLFFYWRIYRAAVRTTRA--INQGFKTTKGSKGIG 343

Mouse   262 DR---RPNGLGPERGAGPTGAEAEPLPTQLNGAP-------GEPAP------------------- 297
            .|   :...|...||.|....::    ...||:.       |.|:|
  Fly   344 SRFEEQRLTLRIHRGRGSNQQDS----MHSNGSTQSTTTTLGTPSPERLSKYATRRLHHHDKIKI 404

Mouse   298 --AGPRDGDALDLEESSSSEHAERPPG-----------------PRRPDRGPRAKGKTRASQVKP 343
              :.|...:..:|.......|..|..|                 ..:..|..:..|...:..::.
  Fly   405 SVSYPSSENISELAGHGDVGHERRQSGNALFAVHYNGTNGRESTESQLYRQQQQHGVASSCYLQV 469

Mouse   344 GDSLP---RRGPGAAGPGASGSGHGEERGGGAKASRWRGRQN---REKRFTF------VLAVVIG 396
            |..||   ||....:..|  ||||..      .|::..||:|   :.|||..      .||:::|
  Fly   470 GKGLPELARRQSNTSEAG--GSGHSR------PANKKMGRRNIKAQVKRFRMETKAAKTLAIIVG 526

Mouse   397 VFVVCWFPFFFTYTLIAVGCP--VPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCR 458
            :|:.||.|||..| :|...|.  |...||:..||.|||||::||:||.:|:.|||.|||:|:||
  Fly   527 MFIFCWCPFFTMY-IIRPFCQDCVDPLLFSVLFWLGYCNSAVNPMIYALFSKDFRFAFKRIICR 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adra2a	NP_031443.4	7tmA_alpha2A_AR	49..452	CDD:320445	153/576 (27%)
		TM helix 1	51..75	CDD:320445	11/25 (44%)
		TM helix 2	84..106	CDD:320445	12/21 (57%)
		TM helix 3	122..144	CDD:320445	13/21 (62%)
		TM helix 4	167..183	CDD:320445	6/15 (40%)
		TM helix 5	209..232	CDD:320445	8/22 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..378		32/186 (17%)
		TM helix 6	388..410	CDD:320445	9/27 (33%)
		TM helix 7	420..445	CDD:320445	13/24 (54%)
Oamb	NP_001262774.1	7tm_4	29..>154	CDD:304433	56/124 (45%)
		7tm_1	37..>181	CDD:278431	60/143 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870