Protein Alignment TBCB and ALF1

DIOPT Version :10

• Sequence 1: NP_001272.2
• Gene: TBCB / 1155
• HGNCID: 1989
• Length: 244
• Species: Homo sapiens
• Sequence 2: NP_014251.1
• Gene: ALF1 / 855574
• SGDID: S000005092
• Length: 254
• Species: Saccharomyces cerevisiae
• Alignment Length: 258
• Identity: 75/258 - (29%)
• Similarity: 114/258 - (44%)
• Gaps: 39/258 - (15%)

Human    11 VTVFISSSLNTFRSEKRYSRSLTIAEFKCKLELLVGSPASCMEL---------ELYGVDDKFYSK 66
            |.|.|.|.|  .|:||....||.:.:||.:|..:.|.....||:         |:|.........
Yeast     2 VRVVIESEL--VRTEKELPNSLKLRQFKDRLYHVTGVEPEDMEIVVKRQYDNKEIYSTKKGGAYS 64

Human    67 LDQEDA--LLGSYPVDDGCRIHVIDHSGAR------LGEYEDVSRVEKYTISQEAYDQRQDTVRS 123
            .:.|||  |.|...:     |.|:..|.|:      ..:.|.:..:|  .||:|.|.:|..:|..
Yeast    65 NEDEDANFLKGEEEL-----IVVVTDSNAQSISNQLATQAEGIPSME--VISEEDYLRRDQSVLR 122

Human   124 FLKRSKLGRYNEEERAQQEAEAAQRLAEEKAQASSIPVGSRCEVRAAGQSPRRGTVMYVGLTDFK 188
            :......||:|..:::|:.|.|.|..|..:.|.:: .:|..|.|...|.:||...:.|||
Yeast   123 WKMAHGYGRFNAAQQSQRAALAKQDEAYAREQLTA-AIGRHCRVTVDGSAPREAILRYVG----- 181

Human   189 P------GYWIGVRYDEPLGKNDGSVNGKRYFECQAK-YGAFVKPAVVTVGDFPEEDYGLDEI 244
            |      |.|.||.:.|..|||||.:||...|...|. :|:||:|..|.:....||...::::
Yeast   182 PLPLDVMGTWCGVEFPEAAGKNDGRINGVTLFGPVAPGHGSFVRPRAVEILSKDEESAEVEDV 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBCB	NP_001272.2	Ubl_TBCB	11..89	CDD:340487	25/88 (28%)
		CAP_GLY	161..229	CDD:460154	28/74 (38%)
ALF1	NP_014251.1	Ubl1_cv_Nsp3_N-like	2..67	CDD:475130	18/66 (27%)
		CAP_GLY	163..229	CDD:460154	27/70 (39%)