DRSC/TRiP Functional Genomics Resources

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Protein Alignment UHRF2 and Su(var)3-9

DIOPT Version :9

Sequence 1:NP_690856.1 Gene:UHRF2 / 115426 HGNCID:12557 Length:802 Species:Homo sapiens
Sequence 2:NP_524357.2 Gene:Su(var)3-9 / 41483 FlyBaseID:FBgn0263755 Length:635 Species:Drosophila melanogaster


Alignment Length:695 Identity:119/695 - (17%)
Similarity:200/695 - (28%) Gaps:274/695 - (39%)


- Green bases have known domain annotations that are detailed below.


Human     5 VRTIDGSKTCTIE-DVSRKATI--EELRERVWALFDVRPECQRLFYRGKQLENGYTLFDYDVGLN 66
            |:.|.|.:|...: ::.|..||  |.|.|:         :.:.|....:|.:      .|::...
  Fly    57 VKAISGVQTVRFKNELERNITIKLERLSEK---------KIKNLLTSKQQRQ------QYEIKQR 106

Human    67 DII-------------QLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARAR 118
            .::             :|..:|....:|.:::.::.:....|..:.        |..||.|:   
  Fly   107 SMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQT--------SLSPSNSS--- 160

Human   119 LIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNG--------SSCKRTN 175
                                |.|:.|....|.|         .|.|..||        |||....
  Fly   161 --------------------GYGSVFGCEEHDV---------DKIPSLNGFAKLKRRRSSCVGAP 196

Human   176 GNIKHKSKENTNKLDSVPS-----TSNSDCVAADE-DVIYHIQYDEYPESGTLEMNVKDLRPRAR 234
            .....:||.|...:...|.     ....:||..|: ..::.:::..|.:|..             
  Fly   197 TPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSEN------------- 248

Human   235 TILKWNEL-NVGDVVMVNYNVESPGQRGFWFDAEITT-----------LKTISRTKKE------L 281
               .|..| ||.|...:...||...|....:.|:|||           ::.|:..:.:      |
  Fly   249 ---TWESLANVADCAEMEKFVERHQQLYEIYIAKITTELEKQLEALPLMENITVAEVDAYEPLNL 310

Human   282 RVKIFL------GGSEGTLNDCKI--------------------ISVDEIFK-----IERPGAH- 314
            ::.:.|      .||.......||                    ::...:|:     :|:|... 
  Fly   311 QIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPI 375

Human   315 ------PLSFADGKFLRRNDPECDLCGGD---PEKKCHSCSCRVCGGKHEPNMQLLCDECNV--- 367
                  .|...|..|:..:|   ::.|.|   ||.....|.|.      |..     :||..   
  Fly   376 RVENNIDLDTIDSNFMYIHD---NIIGKDVPKPEAGIVGCKCT------EDT-----EECTASTK 426

Human   368 -----AYHIYCLNPPLDKV---PEEEYWYCPS-CKTDSSEVVKAGERLKMSKKKAKMPSASTESR 423
                 |..::.......::   |....:.|.| |..|||    ...||....::..:....|.:.
  Fly   427 CCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSS----CSNRLVQHGRQVPLVLFKTANG 487

Human   424 RDWG----------------------------RGMAC--VGRT------------RECTIVPSNH 446
            ..||                            ||.|.  .|||            .|.||..:| 
  Fly   488 SGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAAN- 551

Human   447 YGPI---------PGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVDRG 502
            ||.|         |.:.|...|     :....|..||:.....|                .:..|
  Fly   552 YGNISHFINHSCDPNLAVFPCW-----IEHLNVALPHLVFFTLR----------------PIKAG 595

Human   503 DEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDD 547
            :|.::           ..|.|.:.|....|::.|:.:.|....|:
  Fly   596 EELSF-----------DYIRADNEDVPYENLSTAVRVECRCGADN 629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
UHRF2NP_690856.1 NIRF_N 1..78 CDD:176392 15/88 (17%)
UBQ 3..74 CDD:214563 14/84 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 80..116 6/35 (17%)
Required for interaction with histone H3. /evidence=ECO:0000250 117..311 42/256 (16%)
TTD 125..312 CDD:288962 42/249 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 153..197 11/56 (20%)
Interaction with PCNP 194..288 20/123 (16%)
PHD zinc finger 327..395 15/82 (18%)
PHD_UHRF2 346..392 CDD:277089 8/57 (14%)
putative NLS 405..414 2/8 (25%)
SAD_SRA 446..614 CDD:280363 19/111 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..674
RING zinc finger 720..802
RING 732..775 CDD:238093
Su(var)3-9NP_524357.2 P-loop_NTPase 41..>80 CDD:304359 7/22 (32%)
CHROMO 217..268 CDD:237991 11/66 (17%)
PreSET 362..455 CDD:128744 17/106 (16%)
SET 477..609 CDD:214614 27/164 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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