DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment UHRF2 and Lpt

DIOPT Version :9

Sequence 1:	NP_690856.1	Gene:	UHRF2 / 115426	HGNCID:	12557	Length:	802	Species:	Homo sapiens
Sequence 2:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster

Alignment Length:	770	Identity:	146/770 - (18%)
Similarity:	222/770 - (28%)	Gaps:	305/770 - (39%)

- Green bases have known domain annotations that are detailed below.

Human   122 PGFGIYKVNEL-----VDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHK 181
            |.:| :|.|..     ..:|..|.|:....|.|.....|..|.|.|     |.||.......:..
  Fly   289 PKYG-WKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNK-----GFSCPICQKAYRAA 347

Human   182 SKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGD 246
            |.:...|........:|.|....:...||.:.::.|:...:..|.|.
  Fly   348 SHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCKS------------------ 394

Human   247 VVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVK-IFLGGSEG--TLNDCKIISVDEI--- 305
                  |...||......|:.:  |..:..:.::|.:| |.|...||  |::.    |.||:
  Fly   395 ------NSSGPGSSQQTIDSIV--LSAMDSSSEQLSLKEIELDPLEGKPTMDP----SSDELHKL 447

Human   306 ------------------FKIERPG------------------AHP------------------- 315
                              |.:.|.|                  |.|
  Fly   448 PTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQLALPTISSDRCLSRSMETDLTSD 512

Human   316 ----LSFADGKFLRRND-------------------PECDLC------GGDPEK-------KCHS 344
                |..|..||::..|                   .:|..|      |..|.:       :|..
  Fly   513 KKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLD 577

Human   345 CS-CRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVP-------------------------- 382
            |: |..||.|::....||||||:::|||||:||||:.||
  Fly   578 CTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFG 642

Human   383 EEEYWYCPSCKTDSS-EVVKA----GERLKMSKK-----------------------------KA 413
            :.....||||.:.|| .|.|.    ||.:...:.                             |.
  Fly   643 DSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKC 707

Human   414 KMPSASTESRRDWGRGMACVGRTRECTIVPS------------------------NH---YGPIP 451
            :..:.||.|..|     |..|......|.|.                        ||   .|.:|
  Fly   708 RCSTRSTNSLAD-----AKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMP 767

Human   452 -GIPVGSTWRFRVQVSEAGV-----------HRPHVGGIHGRSNDGAYSL------------VLA 492
             ..|....|...|.:||:|:           .:..:....|...||....            ::.
  Fly   768 ESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQALGNGKDGQLEAAAEEALEKYKDGMVW 832

Human   493 GGFADEVDRGDEFTYT-GSGGKNLAGNKR--------IGAPSADQTLTNMNRALALNCDAPLDDK 548
            .|..:.:..|  ||.: ...|.|:...||        ||..|.        |...|..|:.....
  Fly   833 DGTENAIPEG--FTISINDEGVNILRKKRQRNLQKLGIGGFSV--------RNRGLKKDSEETTA 887

Human   549 IGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRD 613
            :...:......|..::||..:..|:.:..|        :|....::.:.....|.||..
  Fly   888 VDQINSLMTMDKKKKIIRKKQKNKLIEAYP--------VYLQEAFFGKPLLEGGELVMA------ 938

Human   614 DVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQS----KKQPSGTTKR 664
            |.:    :|:.|:.|.::         |.:..|||.|..|.    .|.|:.|.|:
  Fly   939 DTD----SSDEIDASMKV---------YFTRPEGKSPANQDTLAVNKSPAKTVKK 980

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
UHRF2	NP_690856.1	NIRF_N	1..78	CDD:176392
		UBQ	3..74	CDD:214563
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..116
		Required for interaction with histone H3. /evidence=ECO:0000250	117..311		41/217 (19%)
		TTD	125..312	CDD:288962	41/215 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..197		9/43 (21%)
		Interaction with PCNP	194..288		15/94 (16%)
		PHD zinc finger	327..395		32/126 (25%)
		PHD_UHRF2	346..392	CDD:277089	23/72 (32%)
		putative NLS	405..414		1/37 (3%)
		SAD_SRA	446..614	CDD:280363	35/203 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..674		10/29 (34%)
		RING zinc finger	720..802
		RING	732..775	CDD:238093
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985	4/9 (44%)
		PHD_SF	337..392	CDD:304600	8/54 (15%)
		PHD4_KMT2C_like	530..578	CDD:276987	5/47 (11%)
		PHD5_KMT2C_like	580..625	CDD:276988	21/44 (48%)
		PHD6_KMT2C_like	657..707	CDD:276989	5/49 (10%)
		NHP6B	1101..>1237	CDD:227935
		HMG	1173..1231	CDD:197700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000