Protein Alignment CISH and Socs16D

DIOPT Version :9

• Sequence 1: NP_037456.5
• Gene: CISH / 1154
• HGNCID: 1984
• Length: 275
• Species: Homo sapiens
• Sequence 2: NP_001259662.1
• Gene: Socs16D / 32760
• FlyBaseID: FBgn0030869
• Length: 1021
• Species: Drosophila melanogaster
• Alignment Length: 238
• Identity: 62/238 - (26%)
• Similarity: 99/238 - (41%)
• Gaps: 57/238 - (23%)

Human    46 LPKPVMQPLPAGAFLEEVAEGTPAQTES----EPKVLDPEEDLLCIAKTFSYLRESGWYWGSITA 106
            |||..: |..|.|:..|..:..|.:.::    ||:.|.       ...:...:::.|||||.:::
  Fly   801 LPKKAL-PFTAAAYAIEAVKSEPEEVKTNAIQEPRALQ-------FTSSIEKVKDYGWYWGPLSS 857

Human   107 SEARQHLQKMPEGTFLVRDSTHPSYLFTLSVKTTRGPTNVRIEYADSSFRLDSNCLSRPRILAFP 171
            ..|.:.|...|:|:|:||||:...|:|:||.|......:||||....:|...|....:.:
  Fly   858 EAAEKVLSSEPDGSFIVRDSSDDHYIFSLSFKLNNCVRHVRIEQDQGTFSFGSYAKFKSQ----- 917

Human   172 DVVSLVQHYVASCTADTRSD--------SPDPAPTPALPMPKEDAPSDPALPAPPPATAVHLKLV 228
                .:..::......:||.        .|:..|                         :.::|.
  Fly   918 ----TITEFIEKAVEHSRSGRYLFFLHRRPEHGP-------------------------MRVQLT 953

Human   229 QPFVRRSSARSLQHLCRLVINRLVADVD---CLPLPRRMADYL 268
            .|..|....:||||:||.||.:.|...|   .||||||:.|||
  Fly   954 NPVSRFKHVQSLQHMCRFVILKAVIRKDLIQTLPLPRRLLDYL 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CISH	NP_037456.5	SH2_CIS	94..181	CDD:198285	25/86 (29%)
		SOCS_CIS1	235..275	CDD:239703	19/37 (51%)
Socs16D	NP_001259662.1	SH2_SOCS7	839..937	CDD:198251	27/106 (25%)
		SOCS_SOCS7	960..1009	CDD:239710	19/37 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770