Protein Alignment GBP5 and gbp2

DIOPT Version :10

• Sequence 1: NP_443174.1
• Gene: GBP5 / 115362
• HGNCID: 19895
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_001072267.1
• Gene: gbp2 / 779720
• XenbaseID: XB-GENE-5828806
• Length: 591
• Species: Xenopus tropicalis
• Alignment Length: 599
• Identity: 284/599 - (47%)
• Similarity: 396/599 - (66%)
• Gaps: 21/599 - (3%)

Human     1 MALEIHMSDPMCLIENFN-EQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKG 64
            |:.:|||..|:|||||.| .:..:|.||.:|||.||.|||||||||.||||||||||||||...|
 Frog     1 MSAQIHMKYPICLIENRNSNEFVINTEAEQILSQITDPVVVVAIVGKYRTGKSYLMNKLAGSKTG 65

Human    65 FSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYN 129
            |::.||:||.|||||:||||||..|:||||||||||||||||.|:|||..||:||:||||..|||
 Frog    66 FALGSTIQSKTKGIWMWCVPHPCQPSHTLVLLDTEGLGDVEKGDSKNDGWIFSLAVLLSSNLVYN 130

Human   130 TVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASF---FPDLVWTLRDFCLGLEIDG 191
            ::..||..:::.||.|||||:|:|.:::|.    |...:|..|   ||...|.:|||.|.||:||
 Frog   131 SMGTIDHQSMEQLHYVTELTNLIKIKSNPK----EGKDESGEFKRIFPSFTWCVRDFSLILELDG 191

Human   192 QLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDEL 256
            :.||.|:||.||||.|:|:|::.|:|||||.||..:|...|||:||.|...:.|.:||.|.:..|
 Frog   192 KKVTEDDYLMNSLRLKKGTDRKTQDFNLPRECILHYFHSHKCFVFDQPTSSRNLHRLEELQEQNL 256

Human   257 EPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRE 321
            |..||:|..:||.||....:.||||||::|.|..|.:|...|:..|.||.:||:|||:|||:..|
 Frog   257 EETFVEQAQKFCGYIHRDGIAKTLPGGLLVTGRMLAHLTSLYIETIMSGSVPCMENAILALSVIE 321

Human   322 NSAAVQKAIAHYDQQMGQKV-QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETL 385
            |:.|||.|:|.|:..|.:.: :.|.|||||.|.||:.||:||:|||:|.||.|.:|.||||.:.|
 Frog   322 NTGAVQDALAKYETCMNEHLPRFPTETLQEFLHLHQGSEKEALEVFLKRSFNDENQDFQKEFKNL 386

Human   386 LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPR 450
            ||.|..:..:||...|::.|..:::.:...||:.:.||.:||||||.||:::...:..:|...|.
 Frog   387 LDNKMKEFSERNERESTERCQTIIQKLSESLEQRISQGEFSKPGGHKLFLKEKMTIMEEYNTTPH 451

Human   451 KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMM 515
            ||:::.||||:::.:|::...||||.|::||..||:..|:|    ||.|||:|...|..:.|:.:
 Frog   452 KGLKSLEVLQEFISNKKATEAAILQADESLTAKEKEIAESQ----AETAEAERQRQILEEKEKYL 512

Human   516 QE-----RERLHQEQ---VRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQH 572
            ||     ::...|.:   :.:||..:|..:||..::..|::|||.|.|:..||::...|..|:..
 Frog   513 QESMENQKKSFEQHEKMLIEKMEADRQKLIAENGRVIAQKLQEQNAMLTAGFQSKVNDLQREIAD 577

Human   573 AQRTVNNDDPCVLL 586
            ..|...:..||:||
 Frog   578 LNRMNRDTGPCILL 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP5	NP_443174.1	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		171/311 (55%)
		NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501	1..306		170/308 (55%)
		GBP	18..280	CDD:460516	148/265 (56%)
		GBP_C	282..574	CDD:460721	118/300 (39%)
		Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501	529..586		18/56 (32%)
gbp2	NP_001072267.1	GBP	20..280	CDD:460516	147/263 (56%)
		GBP_C	282..579	CDD:460721	118/300 (39%)