DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP5 and gbp2

DIOPT Version :9

Sequence 1:	NP_001127958.1	Gene:	GBP5 / 115362	HGNCID:	19895	Length:	586	Species:	Homo sapiens
Sequence 2:	XP_699217.2	Gene:	gbp2 / 570622	ZFINID:	ZDB-GENE-070912-618	Length:	627	Species:	Danio rerio

Alignment Length:	591	Identity:	253/591 - (42%)
Similarity:	378/591 - (63%)	Gaps:	26/591 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MALEIHMSDPMCLIEN--FNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNK 63
            ||...|||.|:|||||  |. :|.|.:||.:||..|.:|||||::|||||||||||||:||||..
Zfish     1 MAFGRHMSAPVCLIENDEFG-KLCVKKEAKDILDEINEPVVVVSVVGLYRTGKSYLMNRLAGKQS 64

Human    64 GFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVY 128
            ||::.||::|.|||||:||||||....||||||||||||||:|.|.::|..||.||:||||..||
Zfish    65 GFALGSTIESKTKGIWMWCVPHPYKKGHTLVLLDTEGLGDVDKGDERHDTWIFCLAVLLSSALVY 129

Human   129 NTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASF---FPDLVWTLRDFCLGLEID 190
            |::..||..|::.||.|||||:.::.:  .:.:.|||..:||.|   ||..||.:|||.|.|::.
Zfish   130 NSLGVIDNMALEKLHYVTELTENIRVK--AEGNEVEDEDESAEFMRVFPSFVWAVRDFTLELKMG 192

Human   191 GQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDE 255
            .:.:|.|||||::|:||:|:..::..:||||.|:::||..:|||:|..||..:.:.::|.|.::|
Zfish   193 DKPITSDEYLESALKPKKGNSPQIAQYNLPRRCLREFFAPRKCFVFPRPASTQDMKRMEDLTEEE 257

Human   256 LEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQR 320
            |:.||:||...|||||::.:..||:.||..:.|:.|.||...||.||.||.:||:||||::||:.
Zfish   258 LDSEFLQQANTFCSYIYNSTEPKTVKGGRTITGTALGNLAEVYVEAIRSGKVPCLENAVVSLAKI 322

Human   321 ENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETL 385
            :|..||::|:..|..:|....|.|::. :||..:|..:|::|||.|:..||.|.||.:|:||...
Zfish   323 QNVRAVEQALQIYMTEMLSMAQFPLDP-EELSSIHTLAEKKAIEEFINMSFSDNDQIYQQELMGK 386

Human   386 LDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPR 450
            :..:..|:|::|.:||...|..:|:|:|.|||..:..|.|.:|||:..:.....:|.:.|....:
Zfish   387 IHNEYQDLCQQNHQASLMQCQEVLEDVFDPLEMNISNGSYLRPGGYREYRALLAQLTSSYRARTK 451

Human   451 KGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQN---E 512
            ..|.:||||..:||.||.|.:.|||.|::|:..|::|:...:|.|..:   ||...::.||   |
Zfish   452 SQIMSEEVLCMFLKGKEDVGNMILQADESLSAAEQEKEVQMLKNEILQ---QRQRGLEEQNRLQE 513

Human   513 QMMQERERLHQEQ----VRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHA 573
            |..::.||.|||.    |.|||..::....:.:::.|.:::|:.|.|...|:       .|....
Zfish   514 QAFKDMERTHQEHVNQIVHQMEREQERIRRDNERVLEAKLKEREALLKQGFE-------EEASRM 571

Human   574 QRTVNN 579
            |:.:|:
Zfish   572 QKEINS 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP5	NP_001127958.1	GTPase domain (Globular). /evidence=ECO:0000250	1..309		160/312 (51%)
		NLRP3-binding. /evidence=ECO:0000269\|PubMed:22461501	1..306		159/309 (51%)
		GBP	18..280	CDD:308078	135/264 (51%)
		GBP_C	282..574	CDD:308475	103/298 (35%)
		Required for tetramerization, but not for dimerization. /evidence=ECO:0000269\|PubMed:22461501	529..586		10/51 (20%)
gbp2	XP_699217.2	P-loop_NTPase	20..281	CDD:304359	134/263 (51%)
		GBP_C	284..579	CDD:202427	105/305 (34%)
		GBP_C	290..579	CDD:293879	103/299 (34%)
		coiled coil	548..559	CDD:293879	2/10 (20%)
		coiled coil	568..579	CDD:293879	2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I6643
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	565	1.000	Inparanoid score	I5681
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		mtm6791
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980