DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GBP5 and atl

DIOPT Version :9

Sequence 1:NP_001127958.1 Gene:GBP5 / 115362 HGNCID:19895 Length:586 Species:Homo sapiens
Sequence 2:NP_001287506.1 Gene:atl / 42934 FlyBaseID:FBgn0039213 Length:541 Species:Drosophila melanogaster


Alignment Length:467 Identity:106/467 - (22%)
Similarity:189/467 - (40%) Gaps:101/467 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    23 VNQEAL-EIL---SAITQPVVVVAIVGLYRTGKSYLM-----------------NKLAGKN---K 63
            :|::|| |:|   ....:.|.||::.|.:|.|||:|:                 :.|.|::   :
  Fly    19 LNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATDWLGGESDPLE 83

Human    64 GFSVASTVQSHTKGIWIW----CVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSS 124
            |||.....:..|.||.:|    ...:||.....::||||:|..| .::..::...:|||:.:|||
  Fly    84 GFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFD-SQSTVRDCATVFALSTMLSS 147

Human   125 TFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEI 189
            ..:||....|.:..:..|...||...|..|      |..:.|      |..|.:.:||:....|.
  Fly   148 VQIYNLSQNIQEDDLQHLQLFTEYGRLALA------DTGKKP------FQRLQFLVRDWSFPYEA 200

Human   190 DGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPD- 253
            :...:..|:.|:..|   :.||::.......|..|...|.:..||:...|.     ..:.|.|. 
  Fly   201 EYGALGGDKILKRRL---EVSDKQHPELQSLRRHISSCFTEVACFLMPHPG-----LNVATNPKF 257

Human   254 ----DELEPEFVQQVTEFCSYIFSHSMTKTLPGGIM---VNGSRLKNLVL-----TYVNAISSGD 306
                .::.|||...:......:.:       |..::   ::|.|::...|     :|:|.....:
  Fly   258 DGRLQDITPEFKSSLRSLVPMLLA-------PDNLVYKEISGQRVRARDLIQYFQSYMNIYKGNE 315

Human   307 LPCIENAVLALAQRENSAAVQKAIAHYDQQM-----GQKVQLPMETLQ-ELLDLHRTSEREAIEV 365
            ||..::.::|.|:..:..||..|...|.|.|     |.:..|....|| |.|   |..::...:.
  Fly   316 LPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQTEHL---RVKDKALFQF 377

Human   366 FMKNSF--KDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSA--------------LLKDIFG 414
            ..|...  ::..:.|:|:||..|:....:....| |:.:.:.:|              :|..|||
  Fly   378 AAKRKMGGEEFTEKFRKQLEDDLEEVFTNYQAHN-ESKNIFKAARTPAVYFACAVIMYILSGIFG 441

Human   415 PLEEAVKQGIYS 426
            .:      |:|:
  Fly   442 LV------GLYT 447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GBP5NP_001127958.1 GTPase domain (Globular). /evidence=ECO:0000250 1..309 75/326 (23%)
NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501 1..306 74/323 (23%)
GBP 18..280 CDD:308078 68/289 (24%)
GBP_C 282..574 CDD:308475 37/175 (21%)
Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501 529..586
atlNP_001287506.1 GBP 14..289 CDD:280433 69/297 (23%)
MSC <316..>471 CDD:286487 32/142 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142061
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2037
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1027269at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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