Protein Alignment GBP5 and Gbp5

DIOPT Version :9

• Sequence 1: NP_001127958.1
• Gene: GBP5 / 115362
• HGNCID: 19895
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_001102039.2
• Gene: Gbp5 / 362050
• RGDID: 1311040
• Length: 586
• Species: Rattus norvegicus
• Alignment Length: 588
• Identity: 394/588 - (67%)
• Similarity: 479/588 - (81%)
• Gaps: 4/588 - (0%)

Human     1 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGF 65
            ||.||||.:|:|||.|.:|.|..||||||||||||||||||||||||||||||||||||||.|||
  Rat     1 MAPEIHMPEPICLIANTDEHLVTNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKEKGF 65

Human    66 SVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNT 130
            ||.|||||||||||:||||||..|:||||||||||||||||.|.||||||||||:||||||||||
  Rat    66 SVGSTVQSHTKGIWMWCVPHPQKPDHTLVLLDTEGLGDVEKVDEKNDIQIFALAILLSSTFVYNT 130

Human   131 VNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVT 195
            ::|||||||||||:||||||||:.||:.|....::| |..|||||||||||||.||||::||.:|
  Rat   131 MSKIDQGAIDLLHSVTELTDLLRTRNTSDPSETKEP-DDMSFFPDLVWTLRDFFLGLEVNGQAIT 194

Human   196 PDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEF 260
            .|||||.||..|||||:|.|.|||||||||||||.||||:||.||...||:||:||..|||.|:|
  Rat   195 SDEYLEKSLMLKQGSDERTQTFNLPRLCIQKFFPVKKCFVFDSPALGSKLSQLQTLNSDELNPDF 259

Human   261 VQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAA 325
            ||.::||||:||:||.||||||||.|||.||:::|.|||:||:||.||.:||.|:.|.:|||:||
  Rat   260 VQNLSEFCSHIFTHSKTKTLPGGIQVNGPRLESMVQTYVDAINSGALPSMENMVVTLTRRENTAA 324

Human   326 VQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQ 390
            ||||||||||||.||||||.||||.|||||:|.|:||||:|.|.||||.||.||||||:||.||:
  Rat   325 VQKAIAHYDQQMSQKVQLPTETLQLLLDLHKTCEKEAIEIFRKRSFKDDDQCFQKELESLLSAKR 389

Human   391 NDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            ::||::|.:||:..||.||:..|.|||:.|.:|:|:|||||:||:|:.|:|||:|.::|.||.||
  Rat   390 DEICRKNEDASAALCSTLLQSTFQPLEQEVARGVYAKPGGHSLFLQRMEQLKAQYRQQPGKGTQA 454

Human   456 EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER 520
            |||||||||:||.||..||||||.||..||:|||.|.:|||.:||||||.|::.|.||...|:||
  Rat   455 EEVLQKYLKAKEPVSATILQTDQDLTAKEKQKKEEQARAEAARAEAQRLEALRVQEEQRRVEQER 519

Human   521 LHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNN--DDPC 583
            .|||.:||:|..:.|:..|||:.|:|::||:..::....:||.|:|..:||: .|.:::  .|.|
  Rat   520 RHQEHLRQIEFERANFQREQQRKQKQRVQEEMERIKAEQEAQLRALQQQLQN-MRVISHHEHDQC 583

Human   584 VLL 586
            :::
  Rat   584 III 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP5	NP_001127958.1	GTPase domain (Globular). /evidence=ECO:0000250	1..309		233/307 (76%)
		NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501	1..306		231/304 (76%)
		GBP	18..280	CDD:308078	202/261 (77%)
		GBP_C	282..574	CDD:308475	175/291 (60%)
		Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501	529..586		18/58 (31%)
Gbp5	NP_001102039.2	GBP	18..279	CDD:280433	202/261 (77%)
		GBP_C	281..559	CDD:202427	169/277 (61%)
		GBP_C	287..529	CDD:293879	155/241 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83692326
Domainoid	1	1.000	412	1.000	Domainoid score	I10342
eggNOG	1	0.900	-	-		E1_KOG2037
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14183
Inparanoid	1	1.050	783	1.000	Inparanoid score	I7726
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		oto130632
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	LDO	PTHR10751
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	16.310