DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GBP5 and mto1

DIOPT Version :9

Sequence 1:NP_001127958.1 Gene:GBP5 / 115362 HGNCID:19895 Length:586 Species:Homo sapiens
Sequence 2:NP_588284.1 Gene:mto1 / 2539467 PomBaseID:SPCC417.07c Length:1115 Species:Schizosaccharomyces pombe


Alignment Length:566 Identity:104/566 - (18%)
Similarity:229/566 - (40%) Gaps:141/566 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    86 PNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYN----TVNKIDQGAIDLLHNVT 146
            |:.||:.     :..|..:...|:::|:|:  ..:.....::::    |.|.:.:...|:|...:
pombe   167 PSSPNYI-----SSSLDQLPHLDDEDDLQL--TPIKEERNYLHSQDAPTTNALSKKISDILIPAS 224

Human   147 ELTDLLKARNSPDLDRVEDPADSASFFPD---LVWTLRDFCLGLEID-----GQLVTPDEYLENS 203
            .:.||...:|:...:..|....|:....:   ::..||....||::.     .||        |.
pombe   225 AMKDLKDRKNALAKEFEESQPGSSLTLKEQANVIDNLRKEVFGLKLKCYFLYDQL--------NK 281

Human   204 LRPKQGSDQRVQNFNLPRLC--IQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEFVQQVTE 266
            ...::..|...||.:|..|.  :|:          .:..::||::.||:    .::|:       
pombe   282 FHDQEVQDIMKQNIDLKTLTMELQR----------AVAGYEKKISGLES----RIKPD------- 325

Human   267 FCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAVQKAIA 331
               ..|:.|.....|..::...||       |..|:|  :|...:.|..|| ::|.|.....::.
pombe   326 ---QSFNLSTPSPAPSNLITLQSR-------YSQALS--ELETTKRAFAAL-RKEKSKKTNYSVG 377

Human   332 HYDQ----------------------------QMGQKVQLPMETLQE--LLDLHRTSEREAIEVF 366
            .|::                            |:.:||.:|.:...|  :..|.|::|...:::.
pombe   378 AYNEDRNVLSNMLDNERREKEALLQELESLRVQLSKKVPMPAKNTDERVIETLQRSNELLRMDIS 442

Human   367 MKNSF----KDVDQSFQKELETLLDAKQNDICKRNLEASS---DYCSALLKDIFGPLEEAVK-QG 423
            |:|..    |..:....|::|.|..|..:......:||.|   :...:::.......|:::: ..
pombe   443 MQNEALLLRKQENDRLVKQVEELTVALNSGKMNAIVEAESSKNELWDSMMVSRMKTQEQSIELTR 507

Human   424 IYSKPGGHNLFIQKTEE-LKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKK 487
            :|.:       :|..|| .:.|..|..::..:..:.||:|:   |.::..:..|.:.|:::.|:.
pombe   508 LYKQ-------LQDIEEDYENKLMRMEQQWREDVDQLQEYV---EEITQELQDTKEVLSKSSKES 562

Human   488 KE-----AQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQM--EIAKQNWLAE------ 539
            .:     .:::.|||: |.::.....|:||:.:.    |.:|:|.::  ||.:   |:|      
pombe   563 DDYEEVVGKLRTEAER-EIEKFEKTIRENEESIS----LFKEEVEKLTDEITQ---LSERYNDKC 619

Human   540 ------QQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNN 579
                  |:::|..:.:...|:..:|.:..|  ||.:|:..:..|::
pombe   620 HEFDELQKRLQTLEEENNKAKEDSTSKTSN--LLEQLKMTEAEVDS 663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GBP5NP_001127958.1 GTPase domain (Globular). /evidence=ECO:0000250 1..309 43/236 (18%)
NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501 1..306 42/233 (18%)
GBP 18..280 CDD:308078 36/207 (17%)
GBP_C 282..574 CDD:308475 66/349 (19%)
Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501 529..586 13/65 (20%)
mto1NP_588284.1 Cnn_1N 252..319 CDD:285263 15/84 (18%)
Fib_alpha 511..611 CDD:285864 24/117 (21%)
Mto2_bdg 1052..1101 CDD:289572
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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