DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment GBP5 and Gbp5

DIOPT Version :9

Sequence 1:NP_001127958.1 Gene:GBP5 / 115362 HGNCID:19895 Length:586 Species:Homo sapiens
Sequence 2:NP_705792.2 Gene:Gbp5 / 229898 MGIID:2429943 Length:590 Species:Mus musculus


Alignment Length:591 Identity:393/591 - (66%)
Similarity:462/591 - (78%) Gaps:8/591 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGF 65
            ||.||||.:|:|||.:....|..|||||:||||||||||||||||||||||||||||||||.|||
Mouse     1 MAPEIHMPEPLCLIGSTEGHLVTNQEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKEKGF 65

Human    66 SVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNT 130
            ||.|||||||||||:||||||..|:||||||||||||||||.|.|||.||||||:||||||||||
Mouse    66 SVGSTVQSHTKGIWMWCVPHPQKPDHTLVLLDTEGLGDVEKDDKKNDTQIFALAILLSSTFVYNT 130

Human   131 VNKIDQGAIDLLHNVTELTDLLKARNSPDLDRV--EDPADSASFFPDLVWTLRDFCLGLEIDGQL 193
            :|||||||||||||||||||||:.|||.|.::.  |.||| .|||||||||||||.|.|:.:|..
Mouse   131 MNKIDQGAIDLLHNVTELTDLLRTRNSSDSNQTEGEGPAD-MSFFPDLVWTLRDFFLDLQANGHA 194

Human   194 VTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEP 258
            :|.||||||||:.|||||:|.|.|||||||||||||.||||:||.||...||:||.||.::||..
Mouse   195 ITSDEYLENSLKLKQGSDERTQTFNLPRLCIQKFFPVKKCFVFDAPALGSKLSQLPTLSNEELNS 259

Human   259 EFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENS 323
            :|||.::||||:||:.|.||||||||.|||.||::||||||:||:||.||.|||.|:.||:||||
Mouse   260 DFVQDLSEFCSHIFTQSKTKTLPGGIQVNGPRLESLVLTYVDAINSGALPSIENTVVTLARRENS 324

Human   324 AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDA 388
            |||||||.||||.|.:|||||.||||||||||||.||||||:|.|:||||..:.||||||:||.|
Mouse   325 AAVQKAIGHYDQLMSEKVQLPTETLQELLDLHRTCEREAIEIFRKHSFKDEGEFFQKELESLLSA 389

Human   389 KQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGI 453
            ||::|||:|.:||:..||.||..||.|||:.|.|..|.|||||.||:|:.|:|||.|.::|.||.
Mouse   390 KQDEICKKNADASAALCSTLLGSIFKPLEQEVAQEFYHKPGGHKLFLQRMEQLKANYRQQPGKGT 454

Human   454 QAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER 518
            |||||||.||.:||:||..||||||.||:.|.:.|..|.:|||.:.|||||.||:.|.||...|.
Mouse   455 QAEEVLQTYLNAKETVSRTILQTDQVLTDKEIQSKAEQERAEAARLEAQRLEAIRIQEEQRKAEM 519

Human   519 ERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVN----N 579
            ||.||||:||:.:.|.....|||.:.:|:.||:|.::....:||.|:|..:||| .|.:|    :
Mouse   520 ERQHQEQLRQIALEKARVAQEQQWILKQRAQEEADRIKAEQEAQLRALQQQLQH-MREMNHHRRH 583

Human   580 DDPCVL 585
            ...||:
Mouse   584 HHDCVI 589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GBP5NP_001127958.1 GTPase domain (Globular). /evidence=ECO:0000250 1..309 231/309 (75%)
NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501 1..306 229/306 (75%)
GBP 18..280 CDD:308078 199/263 (76%)
GBP_C 282..574 CDD:308475 177/291 (61%)
Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501 529..586 19/61 (31%)
Gbp5NP_705792.2 GTPase domain (Globular). /evidence=ECO:0000250 1..310 231/309 (75%)
NLRP3-binding. /evidence=ECO:0000250|UniProtKB:Q96PP8 1..306 228/305 (75%)
GBP 18..281 CDD:280433 199/263 (76%)
GBP_C 283..561 CDD:202427 170/277 (61%)
GBP_C 289..557 CDD:293879 165/267 (62%)
Required for tetramerization, but not for dimerization. /evidence=ECO:0000250|UniProtKB:Q96PP8 529..590 20/62 (32%)
coiled coil 544..555 CDD:293879 4/10 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C83968999
Domainoid 1 1.000 397 1.000 Domainoid score I11448
eggNOG 00.000 Not matched by this tool.
HGNC 1 1.500 - -
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H14183
Inparanoid 1 1.050 754 1.000 Inparanoid score I8521
Isobase 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55037
OrthoDB 1 1.010 - - D1027269at2759
OrthoFinder 1 1.000 - - FOG0000238
OrthoInspector 1 1.000 - - oto114159
orthoMCL 1 0.900 - - OOG6_100467
Panther 1 1.100 - - LDO PTHR10751
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X242
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1515.410

Return to query results.
Submit another query.