Sequence 1: | NP_001127958.1 | Gene: | GBP5 / 115362 | HGNCID: | 19895 | Length: | 586 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_705792.2 | Gene: | Gbp5 / 229898 | MGIID: | 2429943 | Length: | 590 | Species: | Mus musculus |
Alignment Length: | 591 | Identity: | 393/591 - (66%) |
---|---|---|---|
Similarity: | 462/591 - (78%) | Gaps: | 8/591 - (1%) |
- Green bases have known domain annotations that are detailed below.
Human 1 MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGF 65
Human 66 SVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNT 130
Human 131 VNKIDQGAIDLLHNVTELTDLLKARNSPDLDRV--EDPADSASFFPDLVWTLRDFCLGLEIDGQL 193
Human 194 VTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEP 258
Human 259 EFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENS 323
Human 324 AAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDA 388
Human 389 KQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGI 453
Human 454 QAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQER 518
Human 519 ERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVN----N 579
Human 580 DDPCVL 585 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
GBP5 | NP_001127958.1 | GTPase domain (Globular). /evidence=ECO:0000250 | 1..309 | 231/309 (75%) | |
NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501 | 1..306 | 229/306 (75%) | |||
GBP | 18..280 | CDD:308078 | 199/263 (76%) | ||
GBP_C | 282..574 | CDD:308475 | 177/291 (61%) | ||
Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501 | 529..586 | 19/61 (31%) | |||
Gbp5 | NP_705792.2 | GTPase domain (Globular). /evidence=ECO:0000250 | 1..310 | 231/309 (75%) | |
NLRP3-binding. /evidence=ECO:0000250|UniProtKB:Q96PP8 | 1..306 | 228/305 (75%) | |||
GBP | 18..281 | CDD:280433 | 199/263 (76%) | ||
GBP_C | 283..561 | CDD:202427 | 170/277 (61%) | ||
GBP_C | 289..557 | CDD:293879 | 165/267 (62%) | ||
Required for tetramerization, but not for dimerization. /evidence=ECO:0000250|UniProtKB:Q96PP8 | 529..590 | 20/62 (32%) | |||
coiled coil | 544..555 | CDD:293879 | 4/10 (40%) |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 1 | 0.930 | - | - | C83968999 | |
Domainoid | 1 | 1.000 | 397 | 1.000 | Domainoid score | I11448 |
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
HGNC | 1 | 1.500 | - | - | ||
Hieranoid | 1 | 1.000 | - | - | ||
Homologene | 1 | 1.000 | - | - | H14183 | |
Inparanoid | 1 | 1.050 | 754 | 1.000 | Inparanoid score | I8521 |
Isobase | 0 | 0.000 | Not matched by this tool. | |||
NCBI | 0 | 0.000 | Not matched by this tool. | |||
OMA | 1 | 1.010 | - | - | QHG55037 | |
OrthoDB | 1 | 1.010 | - | - | D1027269at2759 | |
OrthoFinder | 1 | 1.000 | - | - | FOG0000238 | |
OrthoInspector | 1 | 1.000 | - | - | oto114159 | |
orthoMCL | 1 | 0.900 | - | - | OOG6_100467 | |
Panther | 1 | 1.100 | - | - | LDO | PTHR10751 |
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 1 | 1.000 | - | - | X242 | |
SwiftOrtho | 1 | 1.000 | - | - | ||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
15 | 15.410 |