Protein Alignment GBP5 and atln-2

DIOPT Version :10

• Sequence 1: NP_443174.1
• Gene: GBP5 / 115362
• HGNCID: 19895
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_502809.2
• Gene: atln-2 / 189829
• WormBaseID: WBGene00012763
• Length: 520
• Species: Caenorhabditis elegans
• Alignment Length: 454
• Identity: 94/454 - (20%)
• Similarity: 187/454 - (41%)
• Gaps: 77/454 - (16%)

Human     6 HMSDPMCLIENFNEQ---LKVNQEALEIL----SAITQPVVVVAIVGLYRTGKSYLMN----KLA 59
            |...|:.:|...:.|   .::|:.||..:    :...:.:|::::.|.:|.|||:|:|    .|.
 Worm    25 HKVRPVQIIAPSSTQPGKFRLNESALNSVLGHSACANKKIVIISVAGAFRKGKSFLLNFFLEYLY 89

Human    60 GKNK------------------GFSVASTVQSHTKGIWIWCVP----HPNWPNHTLVLLDTEGLG 102
            ..:|                  ||...:.|:..|.|||:|..|    ........:||:||:|
 Worm    90 SLHKSQQSDSSLEWLTDDCQLHGFHWRAGVKRDTVGIWLWGEPIMIESVTGEMFAVVLMDTQG-- 152

Human   103 DVEKADNKNDIQ----IFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRV 163
               ..||.:..|    :|||:.::||..:||.|:.|.:.|:..|....|...:          .:
 Worm   153 ---TFDNNSTYQQCMTVFALSTIVSSVQIYNVVDNIQEDALQHLSLFVEYGRI----------AM 204

Human   164 EDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFF 228
            |.|.:....|..||:.:|||....|.:.......::|:|.|   |.:.::.:.....|..::::|
 Worm   205 EQPHNFGKPFQQLVFCVRDFKNQEEYEFGENGGTDFLDNVL---QTNPEQPEEIKQVRELLREYF 266

Human   229 PKKKCFIFDLPAHQKKLAQLETLPD--DELEPEFVQQVTEFCSYIFS-HSMTKTLPGGIMVNGSR 290
            ...:|::...|.:  |:|:.::...  .:|.|.|.:::.:....:.. |.:...:..|..|...:
 Worm   267 EDIQCYLLPHPGY--KVAERQSFRGHVKDLRPLFREELKKMVPNLLGPHILKPKIVNGKTVTCRK 329

Human   291 LKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQ-LPMETLQELLDL 354
            :......|..:.....||..::.:.|.|:.....|..:|..:|.:.|.:... ..|.:.::||:.
 Worm   330 MIQYFKEYAASFDGETLPQPQSILNANAKLICIEAAHEAKVNYSRGMDRSTYGTRMMSEKKLLEA 394

Human   355 H---------------RTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSD 403
            |               |...:|...:.::...:|::...:| .:.|.:||:...|...:.|..|
 Worm   395 HIKHGITALNIFDKCPRIGAKEVRNLLLEKLQEDINAELEK-YKRLNEAKRVTGCASAMLACGD 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP5	NP_443174.1	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		73/342 (21%)
		NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501	1..306		72/339 (21%)
		GBP	18..280	CDD:460516	66/301 (22%)
		GBP_C	282..574	CDD:460721	25/138 (18%)
		Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501	529..586
atln-2	NP_502809.2	GBP	41..310	CDD:460516	64/288 (22%)