Protein Alignment GBP5 and LOC100495160

DIOPT Version :10

• Sequence 1: NP_443174.1
• Gene: GBP5 / 115362
• HGNCID: 19895
• Length: 586
• Species: Homo sapiens
• Sequence 2: XP_031762264.1
• Gene: LOC100495160 / 100495160
• XenbaseID: XB-GENE-29082575
• Length: 633
• Species: Xenopus tropicalis
• Alignment Length: 586
• Identity: 263/586 - (44%)
• Similarity: 378/586 - (64%)
• Gaps: 20/586 - (3%)

Human     7 MSDPMCLIENFNE-QLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSVAST 70
            ||.|||||||..| :|.:||:|:.||..||:||:||||||.||||||||||||||:|.||::.||
 Frog     7 MSHPMCLIENQEENKLVINQQAVAILQGITEPVIVVAIVGKYRTGKSYLMNKLAGENNGFALGST 71

Human    71 VQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKID 135
            |:|.|||||:||||||..|.||||||||||||||||.|:.||..||:||:|||||.|||:|..||
 Frog    72 VESKTKGIWMWCVPHPRKPGHTLVLLDTEGLGDVEKGDSNNDTWIFSLAVLLSSTLVYNSVGTID 136

Human   136 QGAIDLLHNVTELTD--LLKARNSPDLDRVEDPAD--SASF---FPDLVWTLRDFCLGLEIDGQL 193
            |.:::.|:.|.||.:  .|||:.:.|.|..:|..|  :|.|   .|..:|.:|||.|.:|..|:.
 Frog   137 QDSMEKLYYVQELAERIKLKAKTADDDDDDDDDDDDETAEFKRISPSFIWCVRDFTLKMEHKGKE 201

Human   194 VTPDEYLENSLRPKQGS-DQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELE 257
            :|.||||:|:|:.::|: ..::..:||.|.||.:||...|||:|:.||....|..||.||:.:||
 Frog   202 ITEDEYLQNALKLRRGNKSSKLHAYNLLRECITEFFHSHKCFVFERPASTADLECLEELPESKLE 266

Human   258 PEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQREN 322
            |:||:|..:||.|:|.:|.||||||...|.|..|.||.:|||.:|.||.:||:|||||||||.||
 Frog   267 PKFVEQTHKFCDYVFENSQTKTLPGRNCVTGRMLGNLAVTYVESIRSGSVPCMENAVLALAQIEN 331

Human   323 SAAVQKAIAHYDQQMGQ-KVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLL 386
            :||:|:|::.|:.:|.| :...|.:|.:|........|:.|::|||:.||||..:.:|.:|...|
 Frog   332 TAAIQEALSVYEAEMKQAEGTFPTDTEEEFFQKQTQCEKMAMKVFMERSFKDDKREYQGQLMGGL 396

Human   387 DAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRK 451
            ..|..:..:||.|||...|..|||.:...||:.:..|.:.||||:..|:::.:::...|...|.|
 Frog   397 YQKNTEYARRNEEASIHKCEDLLKVLSASLEKGINDGDFCKPGGYKEFLEEKQKITDTYNNSPGK 461

Human   452 GIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQ 516
            ||:|..|||.:|:.|.::..:||:.|:.|||.:|.|:|.:::.||.:.:.|......:|.|:..:
 Frog   462 GIKAIMVLQLFLQVKNTIEVSILKADECLTEGQKDKEEQRIQREALERKLQEEMDAVKQMEKDKK 526

Human   517 ERERLHQEQVRQMEIAKQNWLAEQQKMQEQ------QMQEQAAQL-STTFQAQNRSLLSELQHAQ 574
            |:||..::||   |:.|:....|.:|.:|:      :..::..|| ...|..:...|..::|..:
 Frog   527 EKERFFEKQV---EMLKEKMKEEHEKYREETQWLIDEKTKEIEQLRKDGFDTKAERLQEQVQDLE 588

Human   575 R 575
            |
 Frog   589 R 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP5	NP_443174.1	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		169/310 (55%)
		NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501	1..306		168/307 (55%)
		GBP	18..280	CDD:460516	145/270 (54%)
		GBP_C	282..574	CDD:460721	105/299 (35%)
		Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501	529..586		11/54 (20%)
LOC100495160	XP_031762264.1	GBP	19..289	CDD:460516	145/269 (54%)
		GBP_C	297..588	CDD:293879	103/293 (35%)
		coiled coil	557..568	CDD:293879	0/10 (0%)
		coiled coil	577..588	CDD:293879	2/10 (20%)