Protein Alignment GBP5 and LOC100488013

DIOPT Version :10

• Sequence 1: NP_443174.1
• Gene: GBP5 / 115362
• HGNCID: 19895
• Length: 586
• Species: Homo sapiens
• Sequence 2: XP_012823014.1
• Gene: LOC100488013 / 100488013
• XenbaseID: XB-GENE-29079035
• Length: 657
• Species: Xenopus tropicalis
• Alignment Length: 586
• Identity: 268/586 - (45%)
• Similarity: 379/586 - (64%)
• Gaps: 22/586 - (3%)

Human     7 MSDPMCLIEN-FNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAG---KNKGFSV 67
            |.:||||||| ..|:|.|||||||||..||||||||||||.||||||||||.|||   ::.||::
 Frog    34 MGEPMCLIENKEGEELTVNQEALEILLEITQPVVVVAIVGKYRTGKSYLMNILAGARNEHSGFAL 98

Human    68 ASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVN 132
            .|||:|.|||||:||||||....||||||||||||||||.|:|||..||:||:|||||.|||::.
 Frog    99 GSTVRSKTKGIWMWCVPHPTKKGHTLVLLDTEGLGDVEKGDSKNDAWIFSLAILLSSTLVYNSMG 163

Human   133 KIDQGAIDLLHNVTELTDLLKARN----SPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQL 193
            .|||.|:|.||.|||||:.:|.::    :.|:|   :..:...|||..:|.:|||.|.||.||..
 Frog   164 TIDQQAMDNLHYVTELTERIKVKSHEGKAEDMD---ETGEFKRFFPSFIWCVRDFTLQLEKDGVP 225

Human   194 VTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEP 258
            :|.|:||.::|..|:|..::||::||||.||:.:|...|||:||.||.:..|.:||.|.:.|||.
 Frog   226 ITEDQYLMDALELKRGVGKKVQDYNLPRQCIRHYFHSHKCFVFDRPASKADLQRLEELQESELEL 290

Human   259 EFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENS 323
            |||.:...|||:|..|...|||.||.:|.|..|.||...|..||.||.:||:||||.|||.||||
 Frog   291 EFVDKAITFCSFINQHCNAKTLVGGTIVTGRTLGNLTDLYTEAIRSGSIPCMENAVKALADRENS 355

Human   324 AAVQKAIAHYDQQMGQKV-QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLD 387
            .|||:|:..|:::|.::: :.|.||.:|.|.:|:..|:||.:|||..||||.:..:|.:|...|.
 Frog   356 RAVQEALTKYEEEMSKQIAKFPTETQEEFLSIHQECEKEATKVFMGLSFKDENGQYQNQLIDELA 420

Human   388 AKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKG 452
            .:::.....|.|.|:..|.|:|:.:...||..:.:|.:|||||:..||.:...|..||.:...||
 Frog   421 EEKSKYSLHNEEESAKKCKAILQKLNESLEREISEGKFSKPGGYTQFISEKNLLVDKYNKTKGKG 485

Human   453 IQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQE 517
            ::|.|:::::|..|:.|..:|||.||:||.|||:.:|.:.:.|..:.|.|.:....|:.|:.|:.
 Frog   486 VKAPEIIEEFLNEKKIVEESILQADQSLTATEKEIEEQRARTETAEREKQIVEENNRRLEKDMEN 550

Human   518 RERL---HQEQVRQ-MEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNR------SLLSELQH 572
            :::.   |::.:.: ||..::..:.:.:.|.:::::|....|...|.||:.      .||.||..
 Frog   551 QKKSLEDHKKMLEEKMEEERKKLMEQNEWMIKEKLKEADELLKKGFDAQSEIVKYQSRLLKELNT 615

Human   573 A 573
            |
 Frog   616 A 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP5	NP_443174.1	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		173/309 (56%)
		NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501	1..306		172/306 (56%)
		GBP	18..280	CDD:460516	151/268 (56%)
		GBP_C	282..574	CDD:460721	107/303 (35%)
		Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501	529..586		13/51 (25%)
LOC100488013	XP_012823014.1	GBP	47..312	CDD:460516	151/267 (57%)
		GBP_C	314..601	CDD:460721	102/286 (36%)