Protein Alignment GBP5 and gbp5

DIOPT Version :10

• Sequence 1: NP_443174.1
• Gene: GBP5 / 115362
• HGNCID: 19895
• Length: 586
• Species: Homo sapiens
• Sequence 2: NP_001120244.2
• Gene: gbp5 / 100145295
• XenbaseID: XB-GENE-5756296
• Length: 636
• Species: Xenopus tropicalis
• Alignment Length: 582
• Identity: 271/582 - (46%)
• Similarity: 379/582 - (65%)
• Gaps: 17/582 - (2%)

Human     7 MSDPMCLIEN-FNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSVAST 70
            |.:|||||.| ..|.|.||||||:||..||||||||||||.||||||||||||||...||::.||
 Frog     6 MEEPMCLIGNKEGEDLIVNQEALQILLKITQPVVVVAIVGKYRTGKSYLMNKLAGARNGFALGST 70

Human    71 VQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKID 135
            |||.|||||:||||||....:|||||||||||||||.|:|||..||:||:|||||.|||::..||
 Frog    71 VQSKTKGIWMWCVPHPTKQGNTLVLLDTEGLGDVEKGDSKNDAWIFSLAILLSSTLVYNSMGTID 135

Human   136 QGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSAS----FFPDLVWTLRDFCLGLEIDGQLVTP 196
            |.|:|.||.|||||:|:|.: |.:....|:..|.:.    |||..:|.:|||.|.||.:|..:|.
 Frog   136 QQAMDNLHYVTELTELIKVK-SDEAQATEEEDDESGEFKRFFPSFIWCVRDFTLKLEKNGSPITE 199

Human   197 DEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEFV 261
            |:||.::|..|:|..::||::||||.||:.:|...|||:||.||....|.:||.|.:.|||.:||
 Frog   200 DQYLLDALELKKGVGKKVQDYNLPRQCIRHYFHSHKCFVFDRPASTLALQRLEELQESELESKFV 264

Human   262 QQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAV 326
            ::..||||.|:..|..|||.||..|.|..|.||.::|..||.||.:||:||||:||||.|||.||
 Frog   265 EKAAEFCSCIYGKSNAKTLVGGYTVTGRLLGNLAVSYTEAIRSGSIPCMENAVIALAQIENSRAV 329

Human   327 QKAIAHYDQQMGQKV-QLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQ 390
            |:|:..|:::|.::: :.|.||.:|.|.:|:..|:||.:|||..||||.:..:||:|...|..|:
 Frog   330 QEALTKYEEEMSKQIAKFPTETQEEFLSIHQECEKEATQVFMGLSFKDENLEYQKQLIDELAEKK 394

Human   391 NDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQA 455
            :.....|.|.|:..|.|:|:.:...||..:..|.:|||||:..||.:...|..:|.|...||::|
 Frog   395 SKYSLYNEEESAKKCKAILQKLSENLEREILNGKFSKPGGYTQFISEKNLLVDEYNRTKGKGVKA 459

Human   456 EEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERER 520
            .|:||::|..||:|..||||.||:||..||:..|.:.:.|..:.|.|.:....|:.|:.::.:::
 Frog   460 LEILQEFLNEKENVEAAILQADQSLTHKEKEIAEQRARTETAEREKQIVEENNRRLEKDIEAQKK 524

Human   521 LHQEQVRQMEIAKQNWLAEQQKMQEQ-------QMQEQAAQLSTTFQAQNRSLLSELQHAQR 575
            ..:|..:.||   :....|::|:.||       :::||...|:..|..::..|.::::..:|
 Frog   525 SLEEHKKMME---EKMEEERKKLMEQNEWMIKEKLKEQEEMLTKGFHKESEMLKNQIEDIKR 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP5	NP_443174.1	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..309		173/306 (57%)
		NLRP3-binding. /evidence=ECO:0000269|PubMed:22461501	1..306		172/303 (57%)
		GBP	18..280	CDD:460516	152/265 (57%)
		GBP_C	282..574	CDD:460721	109/299 (36%)
		Required for tetramerization, but not for dimerization. /evidence=ECO:0000269|PubMed:22461501	529..586		12/54 (22%)
gbp5	NP_001120244.2	GBP	19..283	CDD:460516	152/264 (58%)
		GBP_C	285..582	CDD:460721	109/299 (36%)