Protein Alignment GBP4 and Gbp3

DIOPT Version :9

• Sequence 1: NP_443173.2
• Gene: GBP4 / 115361
• HGNCID: 20480
• Length: 640
• Species: Homo sapiens
• Sequence 2: XP_006501782.1
• Gene: Gbp3 / 55932
• MGIID: 1926263
• Length: 680
• Species: Mus musculus
• Alignment Length: 632
• Identity: 443/632 - (70%)
• Similarity: 527/632 - (83%)
• Gaps: 6/632 - (0%)

Human    13 PGYPE------SESIMMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMN 71
            ||.|.      ||..|.||||||||.:.|||||.:|:.||::|:||:||||||||||||||||||
Mouse    46 PGGPSVHGSAASEWTMEAPICLVENWKNQLTVNLEAIRILEQIAQPLVVVAIVGLYRTGKSYLMN 110

Human    72 RLAGKRNGFPLGSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVL 136
            ||||:.:||.|||||||||||||||||||.:||.||||||||||||||||.:|||||||||||||
Mouse   111 RLAGRNHGFSLGSTVQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVL 175

Human   137 LSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLE 201
            |||:|||||:||||.|||||||:||||.:||||||.||.|:.:|||||..|||||||.||||.||
Mouse   176 LSSTFVYNSMSTINQQALEQLHFVTELTQLIRAKSSPREDKVKDSSEFVGFFPDFIWAVRDFALE 240

Human   202 LKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHMDE 266
            |||:|.|||||||||||||||.|.|.|:|.|||.|||||:||..||||||||||:||:.|..::.
Mouse   241 LKLNGRPITEDEYLENALKLIQGDNLKVQQSNMTRECIRYFFPVRKCFVFDRPTSDKRLLLQIEN 305

Human   267 VPEENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVT 331
            |||..|||:|.::|:.|||||||:.||||||.|:||||.||||||.|||:|||||.|||||||||
Mouse   306 VPENQLERNFQVESEKFCSYIFTNGKTKTLRGGVIVTGNRLGTLVQTYVNAINSGTVPCLENAVT 370

Human   332 ALAQLENPAAVQRAADHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQK 396
            .|||.||..|||:||||||:||||::|||||||||||.||||||:|||||||||||||:..||||
Mouse   371 TLAQRENSIAVQKAADHYSEQMAQRMRLPTDTLQELLTVHAACEKEAIAVFMEHSFKDDEQEFQK 435

Human   397 KLVDTIEKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDY 461
            |||.|||::|.:|:.|||.||.::|||||:||||.|.:||..|.|||||||:||||.:|::|..|
Mouse   436 KLVVTIEERKEEFIRQNEAASIRHCQAELERLSESLRKSISCGAFSVPGGHSLYLEARKKIELGY 500

Human   462 KLVPRKGVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKE 526
            :.|.||||||.|||::|||||.::|:||||||||||.||:||||||..||.||||.||||::|||
Mouse   501 QQVLRKGVKAKEVLKSFLQSQAIMEDSILQSDKALTDGERAIAAERTKKEVAEKELELLRQRQKE 565

Human   527 QQQMMEAQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEIN 591
            |:|:||||||||:|.:|::::|:|.|:|.||||.|::|:||||||||:|.|.|::||:.|..||:
Mouse   566 QEQVMEAQERSFRENIAKLQEKMESEKEMLLREQEKMLEHKLKVQEELLIEGFREKSDMLKNEIS 630

Human   592 QLKEKIESTKNEQLRLLKILDMASNIMIVTLPGASKLLGVGTKYLGS 638
            .|:|::|.|:.:.....:|||...|..|:.||||.||.|||.|:|||
Mouse   631 HLREEMERTRRKPSLFGQILDTIGNAFIMILPGAGKLFGVGLKFLGS 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP4	NP_443173.2	GTPase domain (Globular). /evidence=ECO:0000250	1..325		236/317 (74%)
		GBP	33..296	CDD:280433	199/262 (76%)
		GBP_C	298..594	CDD:202427	205/295 (69%)
		GBP_C	304..594	CDD:293879	201/289 (70%)
		coiled coil	563..574	CDD:293879	8/10 (80%)
		coiled coil	583..594	CDD:293879	4/10 (40%)
Gbp3	XP_006501782.1	GBP	72..335	CDD:308078	199/262 (76%)
		GBP_C	337..633	CDD:308475	205/295 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	419	1.000	Domainoid score	I10631
eggNOG	1	0.900	-	-		E1_KOG2037
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H137329
Inparanoid	1	1.050	875	1.000	Inparanoid score	I7057
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	1	1.000	-	-		mtm9920
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	O	PTHR10751
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8153
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	16.460