DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP4 and atl

DIOPT Version :9

Sequence 1:	NP_443173.2	Gene:	GBP4 / 115361	HGNCID:	20480	Length:	640	Species:	Homo sapiens
Sequence 2:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	464	Identity:	107/464 - (23%)
Similarity:	189/464 - (40%)	Gaps:	80/464 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    31 NQEEQLTVNSKAL-------EILDKISQPVVVVAIVGLYRTGKSYLM-----------------N 71
            ::|....:|..||       |:.|:.   |.||::.|.:|.|||:|:                 :
  Fly    12 SEEHTFVLNEDALSEVLMRDEVKDRF---VCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDATD 73

Human    72 RLAGKRN---GFPLGSTVQSETKGIWMWCVPHL-SKPNH---TLVLLDTEGLGDVEKSNPKNDSW 129
            .|.|:.:   ||......:.:|.||.||....| ..||.   .::||||:|..| .:|..::.:.
  Fly    74 WLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFD-SQSTVRDCAT 137

Human   130 IFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWT 194
            :|||:.:|||..:||....|....|:.|...||...|..|.:..:|            |....:.
  Fly   138 VFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKP------------FQRLQFL 190

Human   195 VRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRP----- 254
            |||::...:.:...:..|:.|:..|::...::|::|:.   |..|...|.:..||:...|
  Fly   191 VRDWSFPYEAEYGALGGDKILKRRLEVSDKQHPELQSL---RRHISSCFTEVACFLMPHPGLNVA 252

Human   255 TNDKQYLNHMDEVPEENLERH----FLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYV 315
            ||.|......|..||......    .|:..||.   ::.....:.:|      .:.|.....:|:
  Fly   253 TNPKFDGRLQDITPEFKSSLRSLVPMLLAPDNL---VYKEISGQRVR------ARDLIQYFQSYM 308

Human   316 DAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQ-----QLRLPTDTLQELLDVHAACE 375
            :......:|..::.:.|.|:..:..||..|.:.|.|.|.:     :..|.|..||   ..|...:
  Fly   309 NIYKGNELPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQ---TEHLRVK 370

Human   376 REAIAVF---MEHSFKDENHEFQKKLVDTIEKKKGDFVLQNEEASA-KYCQAELKRLSEHLTESI 436
            .:|:..|   .:...::...:|:|:|.|.:|:...::...||..:. |..:......:..:...|
  Fly   371 DKALFQFAAKRKMGGEEFTEKFRKQLEDDLEEVFTNYQAHNESKNIFKAARTPAVYFACAVIMYI 435

Human   437 LRGIFSVPG 445
            |.|||.:.|
  Fly   436 LSGIFGLVG 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP4	NP_443173.2	GTPase domain (Globular). /evidence=ECO:0000250	1..325		77/333 (23%)
		GBP	33..296	CDD:280433	74/302 (25%)
		GBP_C	298..594	CDD:202427	32/157 (20%)
		GBP_C	304..594	CDD:293879	32/151 (21%)
		coiled coil	563..574	CDD:293879
		coiled coil	583..594	CDD:293879
atl	NP_001287506.1	GBP	14..289	CDD:280433	74/296 (25%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	30/132 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750