Protein Alignment GBP4 and Gbp7

DIOPT Version :10

• Sequence 1: NP_443173.2
• Gene: GBP4 / 115361
• HGNCID: 20480
• Length: 640
• Species: Homo sapiens
• Sequence 2: NP_663520.2
• Gene: Gbp7 / 229900
• MGIID: 2444421
• Length: 638
• Species: Mus musculus
• Alignment Length: 620
• Identity: 434/620 - (70%)
• Similarity: 520/620 - (83%)
• Gaps: 1/620 - (0%)

Human    22 MMAPICLVENQEEQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFPLGSTV 86
            |.||:|||||:.|:|.|||||:.||::|:|||||||||||||||||||||||||:.:||.||:||
Mouse     7 MEAPVCLVENENEELRVNSKAINILERITQPVVVVAIVGLYRTGKSYLMNRLAGQNHGFNLGTTV 71

Human    87 QSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINH 151
            :|||||||||||||.|||..|||||||||||||||.:||||||||||||||||:|||||:|||||
Mouse    72 RSETKGIWMWCVPHPSKPKFTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINH 136

Human   152 QALEQLHYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITEDEYLE 216
            ||||||||||||.|.|||||..|.:|.:||.||.|||||||||||||.|||||:|..||.|||||
Mouse   137 QALEQLHYVTELTERIRAKSTSRSEEVDDSDEFVSFFPDFIWTVRDFVLELKLEGRVITADEYLE 201

Human   217 NALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHFLMQSD 281
            ||||||||.:.|.|.:|:|||||||||.:||||||||||.||:.|.|::|:||:.|:..|.:||.
Mouse   202 NALKLIPGMSIKAQKANLPRECIRHFFPRRKCFVFDRPTKDKELLVHVEEMPEDQLDHSFQVQSK 266

Human   282 NFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAA 346
            .||||||:::|.|||:|||:|.|.||.|||.|||||||||.|||||||||.|||.||..|||:||
Mouse   267 EFCSYIFSNSKAKTLKEGIVVNGNRLATLVTTYVDAINSGDVPCLENAVTTLAQRENSIAVQKAA 331

Human   347 DHYSQQMAQQLRLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKKKGDFVL 411
            ||||:||||::|||||||||||.||.|||:|||||||||||||||.:|||.||.|||:||.||:.
Mouse   332 DHYSEQMAQRMRLPTDTLQELLTVHTACEKEAIAVFMEHSFKDENQQFQKNLVVTIEEKKEDFLR 396

Human   412 QNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVKANEVLQ 476
            |||.||..:|||||.:|||.|.|||.||:|||||||.||||.:|:||.||:.|||||||||.|||
Mouse   397 QNEAASLSHCQAELDKLSESLRESISRGVFSVPGGHRLYLEARKKVEQDYERVPRKGVKANHVLQ 461

Human   477 NFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQERSFQEY 541
            :|||||:.:|:||:|||||||.|:||:.||||.||||||||||||:||||.||:|||||||::|.
Mouse   462 SFLQSQISIEDSIMQSDKALTDGQKAMEAERAQKEAAEKEQELLRQKQKELQQVMEAQERSYKEN 526

Human   542 MAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIESTKNEQLR 606
            :||:.:|:|.||:|:|||.|..|:||||:|::||.|.|::|.|.::.||:||:::|:..|.:...
Mouse   527 VAQLHEKMETERKNILREQEVKLEHKLKIQKDMLNEGFKRKCEAMDLEISQLQKEIQLNKEKNSS 591

Human   607 L-LKILDMASNIMIVTLPGASKLLGVGTKYLGSRI 640
            | .||||...:::|..:||:.|..|:|.|.|.|::
Mouse   592 LGAKILDGFGDVLISVVPGSGKYFGLGLKILSSQM 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP4	NP_443173.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..325		227/302 (75%)
		GBP	33..296	CDD:460516	197/262 (75%)
		GBP_C	298..594	CDD:460721	210/295 (71%)
Gbp7	NP_663520.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..310		227/302 (75%)
		GBP	18..281	CDD:460516	197/262 (75%)
		GBP_C	283..579	CDD:460721	210/295 (71%)
		Interaction with the CYBA-CYBB complex. /evidence=ECO:0000269|PubMed:21551061	311..638		205/316 (65%)
		C-terminal tail, required for its localization to cytoplasmic vesicle. /evidence=ECO:0000269|PubMed:31689351	590..638		14/37 (38%)