DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP4 and atln-2

DIOPT Version :9

Sequence 1:	NP_443173.2	Gene:	GBP4 / 115361	HGNCID:	20480	Length:	640	Species:	Homo sapiens
Sequence 2:	NP_502809.2	Gene:	atln-2 / 189829	WormBaseID:	WBGene00012763	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	438	Identity:	93/438 - (21%)
Similarity:	176/438 - (40%)	Gaps:	97/438 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    25 PICLV---ENQEEQLTVNSKAL-EILDK---ISQPVVVVAIVGLYRTGKSYLMNRLAG------- 75
            |:.::   ..|..:..:|..|| .:|..   .::.:|::::.|.:|.|||:|:|....
Worm    29 PVQIIAPSSTQPGKFRLNESALNSVLGHSACANKKIVIISVAGAFRKGKSFLLNFFLEYLYSLHK 93

Human    76 ---------------KRNGFPLGSTVQSETKGIWMWCVP----HLSKPNHTLVLLDTEGLGDVEK 121
                           :.:||...:.|:.:|.|||:|..|    .::.....:||:||:|..| ..
Worm    94 SQQSDSSLEWLTDDCQLHGFHWRAGVKRDTVGIWLWGEPIMIESVTGEMFAVVLMDTQGTFD-NN 157

Human   122 SNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQLHYVTELAELIRAKSCPRPDEAEDSSEFAS 186
            |..:....:|||:.::||..:||.|..|...||:.|....|...:          ..|....|..
Worm   158 STYQQCMTVFALSTIVSSVQIYNVVDNIQEDALQHLSLFVEYGRI----------AMEQPHNFGK 212

Human   187 FFPDFIWTVRDFTLELKLDGNPITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVF 251
            .|...::.||||..:.:.:.......::|:|.|:..|.:..:|:   ..||.:|.:|...:|::.
Worm   213 PFQQLVFCVRDFKNQEEYEFGENGGTDFLDNVLQTNPEQPEEIK---QVRELLREYFEDIQCYLL 274

Human   252 DRP----TNDKQYLNHMDEVP---EENLER--------HFLMQSDNFCSYIFTHAKTKTLREGII 301
            ..|    ...:.:..|:.::.   .|.|::        |.|              |.|.: .|..
Worm   275 PHPGYKVAERQSFRGHVKDLRPLFREELKKMVPNLLGPHIL--------------KPKIV-NGKT 324

Human   302 VTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAAVQRAADHYSQQMAQQ---LRLPTDT 363
            ||.:::......|..:.:...:|..::.:.|.|:|....|...|..:||:.|.:.   .|:.::
Worm   325 VTCRKMIQYFKEYAASFDGETLPQPQSILNANAKLICIEAAHEAKVNYSRGMDRSTYGTRMMSE- 388

Human   364 LQELLDVHA-----------ACER----EAIAVFMEHSFKDENHEFQK 396
             ::||:.|.           .|.|    |...:.:|...:|.|.|.:|
Worm   389 -KKLLEAHIKHGITALNIFDKCPRIGAKEVRNLLLEKLQEDINAELEK 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP4	NP_443173.2	GTPase domain (Globular). /evidence=ECO:0000250	1..325		72/347 (21%)
		GBP	33..296	CDD:280433	66/307 (21%)
		GBP_C	298..594	CDD:202427	25/117 (21%)
		GBP_C	304..594	CDD:293879	22/111 (20%)
		coiled coil	563..574	CDD:293879
		coiled coil	583..594	CDD:293879
atln-2	NP_502809.2	P-loop_NTPase	41..310	CDD:393306	62/282 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820