DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP4 and atln-1

DIOPT Version :9

Sequence 1:	NP_443173.2	Gene:	GBP4 / 115361	HGNCID:	20480	Length:	640	Species:	Homo sapiens
Sequence 2:	NP_001023492.1	Gene:	atln-1 / 177059	WormBaseID:	WBGene00021868	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	117/511 - (22%)
Similarity:	195/511 - (38%)	Gaps:	128/511 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     3 ERTLHAAVPTPGYPESESIMMAP-----ICLVENQEEQLTVNSKALE--ILD-KIS-QPVVVVAI 58
            |...|......|:.|...:...|     :.:||:.:....:|::.||  :|| |:: :.|.|:.:
Worm     8 EHNEHQQQQHAGHVEDVLLPKEPQAVRVVEVVEDTDHSFELNTELLEKILLDPKVADKKVAVIGV 72

Human    59 VGLYRTGKSYLMN-------------RLAGK--------------RNGFPLGSTVQSETKGIWMW 96
            .|.||.|||:|:|             ::.|:              .:||......:.:|.||.:|
Worm    73 AGAYRKGKSFLLNFFLRYLTWRSKADKVMGEVELDNSQWMSPNSPLSGFSWRGGSERDTNGILIW 137

Human    97 CVPHLSKPNH----TLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTINHQALEQL 157
            ..|.:.|..:    .::|:||:|..| .:|..|:.:.||||:.::||..:||....|....|:.|
Worm   138 SEPFIMKDKNGEEIAVLLMDTQGAFD-SQSTVKDCATIFALSTMISSVQIYNLSQNIQEDDLQHL 201

Human   158 HYVTELAELIRAKSCPRPDEAEDSSEFASFFPDFIWTVRDFTL----ELKLDGNPITEDEYLENA 218
            ...||...|....|..:|            |...::.|||::.    |....|.....|..||.:
Worm   202 QLFTEYGRLALEDSASKP------------FQSLLFLVRDWSFPYEAEFGFQGGQRVLDRRLEVS 254

Human   219 LKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRP-----TN----------DKQYLNHMDEVP 268
            .|    ::.::|..   |:.||..|...:||:...|     ||          :.::...:..:.
Worm   255 EK----QHAELQQL---RQHIRSCFEDIRCFLMPHPGLKVATNPNFDGKLVDIENEFQQQLGVMI 312

Human   269 EENLERHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTAL 333
            ...|:.|.|:..:       .:.:..|.||        |......|:.......:|..::.:.|.
Worm   313 PRLLDSHALVHKE-------INGQKMTCRE--------LLEYFKAYMHIFRGQDLPEPKSMLMAT 362

Human   334 AQLENPAAVQRAADHYSQQMAQQL--RLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQK 396
            |:..|.|||..|...|.::|.:..  ..|..:..|||:.|...:..||            .||:.
Worm   363 AEANNLAAVASARAVYQREMEEVCGGDTPYMSTNELLEHHDRVKNIAI------------REFRN 415

Human   397 KLVDTIEKKKG--DFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLY 450
                  .:|.|  ||.:|           .|:||...|.|| ......|..|.||:
Worm   416 ------ARKMGGVDFSMQ-----------FLERLESDLQES-YENYLKVNNGKNLF 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP4	NP_443173.2	GTPase domain (Globular). /evidence=ECO:0000250	1..325		83/380 (22%)
		GBP	33..296	CDD:280433	71/316 (22%)
		GBP_C	298..594	CDD:202427	37/157 (24%)
		GBP_C	304..594	CDD:293879	36/151 (24%)
		coiled coil	563..574	CDD:293879
		coiled coil	583..594	CDD:293879
atln-1	NP_001023492.1	P-loop_NTPase	43..325	CDD:393306	71/301 (24%)
atln-1	NP_001023492.1	GBP_C	351..>447	CDD:308475	30/125 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920