Protein Alignment GBP4 and LOC100488013

DIOPT Version :10

• Sequence 1: NP_443173.2
• Gene: GBP4 / 115361
• HGNCID: 20480
• Length: 640
• Species: Homo sapiens
• Sequence 2: XP_012823014.1
• Gene: LOC100488013 / 100488013
• XenbaseID: XB-GENE-29079035
• Length: 657
• Species: Xenopus tropicalis
• Alignment Length: 632
• Identity: 315/632 - (49%)
• Similarity: 430/632 - (68%)
• Gaps: 30/632 - (4%)

Human    22 MMAPICLVENQE-EQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRN---GFPL 82
            |..|:||:||:| |:||||.:|||||.:|:||||||||||.||||||||||.|||.||   ||.|
 Frog    34 MGEPMCLIENKEGEELTVNQEALEILLEITQPVVVVAIVGKYRTGKSYLMNILAGARNEHSGFAL 98

Human    83 GSTVQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVS 147
            ||||:|:|||||||||||.:|..||||||||||||||||.:.|||:|||:||:||||:.||||:.
 Frog    99 GSTVRSKTKGIWMWCVPHPTKKGHTLVLLDTEGLGDVEKGDSKNDAWIFSLAILLSSTLVYNSMG 163

Human   148 TINHQALEQLHYVTELAELIRAKSCP-RPDEAEDSSEFASFFPDFIWTVRDFTLELKLDGNPITE 211
            ||:.||::.|||||||.|.|:.||.. :.::.:::.||..|||.|||.||||||:|:.||.||||
 Frog   164 TIDQQAMDNLHYVTELTERIKVKSHEGKAEDMDETGEFKRFFPSFIWCVRDFTLQLEKDGVPITE 228

Human   212 DEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLERHF 276
            |:||.:||:|..|...|:|:.|:||:||||:|...||||||||.: |..|..::|:.|..||..|
 Frog   229 DQYLMDALELKRGVGKKVQDYNLPRQCIRHYFHSHKCFVFDRPAS-KADLQRLEELQESELELEF 292

Human   277 LMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLENPAA 341
            :.::..|||:|..|...|||..|.||||:.||.|...|.:||.||::||:||||.|||..||..|
 Frog   293 VDKAITFCSFINQHCNAKTLVGGTIVTGRTLGNLTDLYTEAIRSGSIPCMENAVKALADRENSRA 357

Human   342 VQRAADHYSQQMAQQL-RLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTIEKK 405
            ||.|...|.::|::|: :.||:|.:|.|.:|..||:||..|||..||||||.::|.:|:|.:.::
 Frog   358 VQEALTKYEEEMSKQIAKFPTETQEEFLSIHQECEKEATKVFMGLSFKDENGQYQNQLIDELAEE 422

Human   406 KGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRKGVK 470
            |..:.|.|||.|||.|:|.|::|:|.|...|..|.||.|||:..::.||..:...|.....||||
 Frog   423 KSKYSLHNEEESAKKCKAILQKLNESLEREISEGKFSKPGGYTQFISEKNLLVDKYNKTKGKGVK 487

Human   471 ANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMMEAQE 535
            |.|:::.||..:.:|||||||:|::|||.||.|..:||..|.||:|::::.|..:..::.||.|:
 Frog   488 APEIIEEFLNEKKIVEESILQADQSLTATEKEIEEQRARTETAEREKQIVEENNRRLEKDMENQK 552

Human   536 RSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKIEST 600
            :|.:::...:|:|:||||:.|:.::|.::|.|||..:|:||:.|..:||.:
 Frog   553 KSLEDHKKMLEEKMEEERKKLMEQNEWMIKEKLKEADELLKKGFDAQSEIV-------------- 603

Human   601 KNEQLRLLKILDMAS-----NIMIVTL---PGASKLLGVGTKYLGSR 639
             ..|.||||.|:.|:     |:.|:.|   .|...|.|.|...|..|
 Frog   604 -KYQSRLLKELNTAAAAQPLNVNILGLGRGRGRGWLRGRGRGLLRGR 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP4	NP_443173.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..325		184/307 (60%)
		GBP	33..296	CDD:460516	163/267 (61%)
		GBP_C	298..594	CDD:460721	128/296 (43%)
LOC100488013	XP_012823014.1	GBP	47..312	CDD:460516	162/265 (61%)
		GBP_C	314..601	CDD:460721	126/286 (44%)