Protein Alignment GBP4 and gbp5

DIOPT Version :10

• Sequence 1: NP_443173.2
• Gene: GBP4 / 115361
• HGNCID: 20480
• Length: 640
• Species: Homo sapiens
• Sequence 2: NP_001120244.2
• Gene: gbp5 / 100145295
• XenbaseID: XB-GENE-5756296
• Length: 636
• Species: Xenopus tropicalis
• Alignment Length: 625
• Identity: 320/625 - (51%)
• Similarity: 435/625 - (69%)
• Gaps: 26/625 - (4%)

Human    22 MMAPICLVENQE-EQLTVNSKALEILDKISQPVVVVAIVGLYRTGKSYLMNRLAGKRNGFPLGST 85
            |..|:||:.|:| |.|.||.:||:||.||:||||||||||.||||||||||:|||.||||.||||
 Frog     6 MEEPMCLIGNKEGEDLIVNQEALQILLKITQPVVVVAIVGKYRTGKSYLMNKLAGARNGFALGST 70

Human    86 VQSETKGIWMWCVPHLSKPNHTLVLLDTEGLGDVEKSNPKNDSWIFALAVLLSSSFVYNSVSTIN 150
            |||:|||||||||||.:|..:|||||||||||||||.:.|||:|||:||:||||:.||||:.||:
 Frog    71 VQSKTKGIWMWCVPHPTKQGNTLVLLDTEGLGDVEKGDSKNDAWIFSLAILLSSTLVYNSMGTID 135

Human   151 HQALEQLHYVTELAELIRAKSCPRPDEA-------EDSSEFASFFPDFIWTVRDFTLELKLDGNP 208
            .||::.|||||||.|||:.||    |||       ::|.||..|||.|||.||||||:|:.:|:|
 Frog   136 QQAMDNLHYVTELTELIKVKS----DEAQATEEEDDESGEFKRFFPSFIWCVRDFTLKLEKNGSP 196

Human   209 ITEDEYLENALKLIPGKNPKIQNSNMPRECIRHFFRKRKCFVFDRPTNDKQYLNHMDEVPEENLE 273
            ||||:||.:||:|..|...|:|:.|:||:||||:|...||||||||.:... |..::|:.|..||
 Frog   197 ITEDQYLLDALELKKGVGKKVQDYNLPRQCIRHYFHSHKCFVFDRPASTLA-LQRLEELQESELE 260

Human   274 RHFLMQSDNFCSYIFTHAKTKTLREGIIVTGKRLGTLVVTYVDAINSGAVPCLENAVTALAQLEN 338
            ..|:.::..|||.|:..:..|||..|..|||:.||.|.|:|.:||.||::||:||||.||||:||
 Frog   261 SKFVEKAAEFCSCIYGKSNAKTLVGGYTVTGRLLGNLAVSYTEAIRSGSIPCMENAVIALAQIEN 325

Human   339 PAAVQRAADHYSQQMAQQL-RLPTDTLQELLDVHAACEREAIAVFMEHSFKDENHEFQKKLVDTI 402
            ..|||.|...|.::|::|: :.||:|.:|.|.:|..||:||..|||..||||||.|:||:|:|.:
 Frog   326 SRAVQEALTKYEEEMSKQIAKFPTETQEEFLSIHQECEKEATQVFMGLSFKDENLEYQKQLIDEL 390

Human   403 EKKKGDFVLQNEEASAKYCQAELKRLSEHLTESILRGIFSVPGGHNLYLEEKKQVEWDYKLVPRK 467
            .:||..:.|.|||.|||.|:|.|::|||:|...||.|.||.|||:..::.||..:..:|.....|
 Frog   391 AEKKSKYSLYNEEESAKKCKAILQKLSENLEREILNGKFSKPGGYTQFISEKNLLVDEYNRTKGK 455

Human   468 GVKANEVLQNFLQSQVVVEESILQSDKALTAGEKAIAAERAMKEAAEKEQELLREKQKEQQQMME 532
            ||||.|:||.||..:..||.:|||:|::||..||.||.:||..|.||:|::::.|..:..::.:|
 Frog   456 GVKALEILQEFLNEKENVEAAILQADQSLTHKEKEIAEQRARTETAEREKQIVEENNRRLEKDIE 520

Human   533 AQERSFQEYMAQMEKKLEEERENLLREHERLLKHKLKVQEEMLKEEFQKKSEQLNKEINQLKEKI 597
            ||::|.:|:...||:|:||||:.|:.::|.::|.|||.|||||.:.|.|:||.|..:|..:|.|.
 Frog   521 AQKKSLEEHKKMMEEKMEEERKKLMEQNEWMIKEKLKEQEEMLTKGFHKESEMLKNQIEDIKRKN 585

Human   598 ESTKNEQLRLLKILDMASNIMIVTLPGASKLLGVGTKYLG 637
            .:.....|       :...:.::.||     :|:..:.||
 Frog   586 SAAAERSL-------LGDILSVIFLP-----IGLAARELG 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP4	NP_443173.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..325		184/310 (59%)
		GBP	33..296	CDD:460516	164/270 (61%)
		GBP_C	298..594	CDD:460721	141/296 (48%)
gbp5	NP_001120244.2	GBP	19..283	CDD:460516	163/268 (61%)
		GBP_C	285..582	CDD:460721	141/296 (48%)