DRSC/TRiP Functional Genomics Resources

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Protein Alignment FCRL3 and him-4

DIOPT Version :9

Sequence 1:NP_001307262.1 Gene:FCRL3 / 115352 HGNCID:18506 Length:742 Species:Homo sapiens
Sequence 2:NP_001024582.1 Gene:him-4 / 181187 WormBaseID:WBGene00001863 Length:5198 Species:Caenorhabditis elegans


Alignment Length:824 Identity:173/824 - (20%)
Similarity:289/824 - (35%) Gaps:238/824 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    19 VAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKH------------DK 71
            |.|..::|......||.:...|.|.|.:...  .:.|..|:.|.:.:.|::            ::
 Worm  2285 VPPTIIMLDKDKNKTAVEHSTVTLSCPATGK--PEPDITWFKDGEAIHIENIADIIPNGELNGNQ 2347

Human    72 IQIT-----EPGNYQCKTRGS--SLSDAVHVEFSPDWLILQALHPVFEGDNVILRCQGKDNKNT- 128
            ::||     :.|.|.|:...|  |:...|:|..        ...|..|.|.:....:.:.|:.. 
 Worm  2348 LKITRIKEGDAGKYTCEADNSAGSVEQDVNVNV--------ITIPKIEKDGIPSDYESQQNERVV 2404

Human   129 ----------HQKVYYKDGKQLPN------SYNLEKITVNSV-SRDNSKYHCTAYRKFYILDIEV 176
                      .:..:.|.||.|.:      |.|.:|:.:..: ..|:|||.|.|..:      ..
 Worm  2405 ISCPVYARPPAKITWLKAGKPLQSDKFVKTSANGQKLYLFKLRETDSSKYTCIATNE------AG 2463

Human   177 TSK---PLNIQVQELFLHP-VLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLG- 236
            |.|   .:::.|...|..| ::|  ..|...|:|.||.|..:.||. |.:    :..:|...:. 
 Worm  2464 TDKRDFKVSMLVAPSFDEPNIVR--RITVNSGNPSTLHCPAKGSPS-PTI----TWLKDGNAIEP 2521

Human   237 ----LGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGG 297
                :.:....:|||......|.|.|.|   ..|:|:....|.:.:.|...||.:..   |....
 Worm  2522 NDRYVFFDAGRQLQISKTEGSDQGRYTC---IATNSVGSDDLENTLEVIIPPVIDGE---RREAV 2580

Human   298 QLIEGENMVLICSVAQGSGTVTFSWHKEG--------------RVRSLGRKTQRSLLAELHVLTV 348
            .:|||.:..|.|.  ..|..|...|.|:|              ::.|.|:|        :..|:.
 Worm  2581 AVIEGFSSELFCD--SNSTGVDVEWQKDGLTINQDTLRGDSFIQIPSSGKK--------MSFLSA 2635

Human   349 KESDAGRYYCAADN------------VHSP------ILSTWIRVTVRIPVSHPVLTFRAPRAHTV 395
            ::||:|||.|...|            |:.|      :.|..|:..|..   :||           
 Worm  2636 RKSDSGRYTCIVRNPAGEARKLFDFAVNDPPSISDELSSANIQTIVPY---YPV----------- 2686

Human   396 VGDLLELHCESLRGSP-PILYRFYHEDVTLGNSSAP---SGGGASFNLSLT-AEHSGNYSCDADN 455
                 |::| .:.||| |.:|..: :|..|...||.   :..|.:..:..: .||:|.|:|:|.|
 Worm  2687 -----EINC-VVSGSPHPKVYWLF-DDKPLEPDSAAYELTNNGETLKIVRSQVEHAGTYTCEAQN 2744

Human   456 GLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPI--LYWFYHEDDTLG 518
            .:|......: :|||.|   |..........|.|||.:.|.|.: ..|.|:  :||..|::....
 Worm  2745 NVGKARKDFL-VRVTAP---PHFEKEREEVVARVGDTMLLTCNA-ESSVPLSSVYWHAHDESVQN 2804

Human   519 NISAHSGGGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNR------TGLTAAGI 577
            .:             :|::::.|..               |||||....:.      |.:..|||
 Worm  2805 GV-------------ITSKYAANEK---------------TLNVTNIQLDDEGFYYCTAVNEAGI 2841

Human   578 TGLVLSILVLAA-----AAALLHYARARRKPGGLSATGTSSHSPSECQEPSSSRPSRID------ 631
            |.....::|:..     ...|......:|.....|||||.  .|:........|.:..|      
 Worm  2842 TKKFFKLIVIETPYFLDQQKLYPIILGKRLTLDCSATGTP--PPTILFMKDGKRLNESDEVDIIG 2904

Human   632 -------PQEPTHSK-------------------PLAPMELEPMYSNVNPGDSNPIYSQ------ 664
                   ||:....:                   .|.|.:|...:.||.....:|:..:      
 Worm  2905 STLVIDNPQKEVEGRYTCIAENKAGRSEKDMMVEVLLPPKLSKEWINVEVQAGDPLTLECPIEDT 2969

Human   665 -----IWSIQHTKENSANCPMMHQEHEELTVLYSELKKTHPDDS 703
                 .||.|..|:...:  |..|...:.:.||  :.:..|:|:
 Worm  2970 SGVHITWSRQFGKDGQLD--MRAQSSSDKSKLY--IMQATPEDA 3009

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FCRL3NP_001307262.1 Ig 23..97 CDD:299845 19/92 (21%)
Ig 101..185 CDD:299845 19/104 (18%)
IG_like 110..166 CDD:214653 15/73 (21%)
Ig_3 192..264 CDD:290638 19/77 (25%)
Ig_2 290..376 CDD:290606 26/117 (22%)
IG_like 301..376 CDD:214653 24/106 (23%)
Ig_2 383..469 CDD:290606 22/90 (24%)
IG_like 390..469 CDD:214653 20/83 (24%)
Ig_3 475..548 CDD:290638 14/74 (19%)
IG_like 487..562 CDD:214653 15/76 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 603..655 15/83 (18%)
ITIM motif 1 648..653 0/4 (0%)
ITIM motif 2 660..665 1/15 (7%)
ITIM motif 3 690..695 2/4 (50%)
ITIM motif 4 720..725
him-4NP_001024582.1 IG_like 442..515 CDD:214653
IG 527..605 CDD:214652
Ig 628..694 CDD:319273
I-set 702..789 CDD:369462
I-set 793..881 CDD:369462
Ig 899..974 CDD:386229
I-set 1012..1081 CDD:369462
Ig 1109..1172 CDD:319273
Ig 1196..1263 CDD:319273
IG_like 1277..1358 CDD:214653
I-set 1373..1450 CDD:369462
Ig 1474..1544 CDD:386229
IGc2 1563..1628 CDD:197706
Ig 1651..1732 CDD:386229
Ig 1755..1818 CDD:319273
Ig 1839..1912 CDD:386229
Ig 1930..2002 CDD:386229
IG_like 2014..2095 CDD:214653
Ig 2094..2182 CDD:386229
Ig 2190..2283 CDD:386229
I-set 2296..2380 CDD:369462 18/85 (21%)
Ig 2384..2471 CDD:386229 19/92 (21%)
IGc2 2492..2556 CDD:197706 18/71 (25%)
Ig 2580..2654 CDD:386229 21/83 (25%)
Ig 2686..2753 CDD:319273 21/84 (25%)
IG_like 2768..2850 CDD:214653 23/110 (21%)
I-set 2854..2939 CDD:369462 12/86 (14%)
IG_like 2951..3031 CDD:214653 13/63 (21%)
I-set 3046..3116 CDD:369462
I-set 3127..3213 CDD:369462
Ig 3217..3292 CDD:386229
I-set 3300..3386 CDD:369462
I-set 3396..3472 CDD:369462
I-set 3481..3569 CDD:369462
I-set 3591..3663 CDD:369462
Ig 3667..3762 CDD:386229
Ig 3775..3848 CDD:386229
Ig 3859..3947 CDD:386229
IGc2 3968..4031 CDD:197706
Ig_3 4045..4119 CDD:372822
Ig_3 4136..4210 CDD:372822
Ig <4262..4314 CDD:386229
Ig 4318..4406 CDD:386229
IG_like 4418..4496 CDD:214653
I-set 4570..4654 CDD:369462
I-set 4752..4836 CDD:369462
EGF_CA 4996..5027 CDD:238011
EGF_CA 5034..5076 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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