Protein Alignment CIRBP and eIF4H1

DIOPT Version :10

• Sequence 1: NP_001287758.1
• Gene: CIRBP / 1153
• HGNCID: 1982
• Length: 297
• Species: Homo sapiens
• Sequence 2: NP_001285330.1
• Gene: eIF4H1 / 49809
• FlyBaseID: FBgn0262734
• Length: 388
• Species: Drosophila melanogaster
• Alignment Length: 206
• Identity: 61/206 - (29%)
• Similarity: 88/206 - (42%)
• Gaps: 55/206 - (26%)

Human     9 FVGGLSFDTNEQSLEQVFSKYGQISEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVD 73
            |||.|.....:..:.::|..: ::..|.:||||||.:.:||.:|.||.:|:.:.|:      ..|
  Fly    32 FVGNLPQGLVQGDVIKIFQDF-EVKYVRLVKDRETDQFKGFCYVEFETLDNLERAL------ECD 89

Human    74 GR--------QIRVDQAGKSSDNRSRGYRGGSAGG-------------RG----------FFRGG 107
            ||        .:|:|.|.:..::|..|..||..||             ||          :.|||
  Fly    90 GRIKLDDLSAPLRIDIADRRKNDRPGGGVGGGNGGMTRGDGGRDGFQKRGPPRQGGSSQSYSRGG 154

Human   108 RGRGRGFSRGGGDRGYGGNRFESRSG---GYGGSRDYYSSRSQSGGYSDRSSGGSYRDSYDS--- 166
            .|.|.|...|||.   .|||.:||..   .|||..|    ||:..|.|...|||.....|:.
  Fly   155 PGTGGGGREGGGG---SGNRGDSRGSYIDSYGGHND----RSRGVGGSGAGSGGGMNRGYNDRPA 212

Human   167 ----YGKSHSE 173
                ||..:::
  Fly   213 NRGRYGSFNND 223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIRBP	NP_001287758.1	RRM_CIRBP_RBM3	6..85	CDD:409883	25/83 (30%)
eIF4H1	NP_001285330.1	RRM_eIF4H	24..110	CDD:409835	25/84 (30%)