DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adcy8 and Ac78C

DIOPT Version :9

Sequence 1:	NP_033753.2	Gene:	Adcy8 / 11514	MGIID:	1341110	Length:	1249	Species:	Mus musculus
Sequence 2:	NP_001262138.1	Gene:	Ac78C / 40333	FlyBaseID:	FBgn0024150	Length:	1727	Species:	Drosophila melanogaster

Alignment Length:	1528	Identity:	491/1528 - (32%)
Similarity:	735/1528 - (48%)	Gaps:	394/1528 - (25%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 DDGSGSRPQRLLWQTA--VRHITEQRFIHGHRGGG-GGGVSRKASNPAGSGPNHHAPQLSSDSVL 87
            |:|||..|..|...|.  :.::.:::     :||. .|||:::.             .|...||.
  Fly   189 DNGSGDLPPSLRASTTSILSNLRKKQ-----QGGPLRGGVAKQT-------------PLRVQSVR 235

Mouse    88 PL---YSLGPGERAHNTG--GTKVFPERSGSGSASGSGGGGDLGFLHLDCAPSNSDFF--LNGGY 145
            .:   .:.||..|..:..  |...|.....||::..|..|...       .|.|::.:  ...|.
  Fly   236 IVEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPGQSQ-------RPLNNEMYSAFKSGN 293

Mouse   146 SYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLK 210
            ..:|::.|:|.||||...|||.|..|...||:||.:::||:|.:.|:.|..:.: :..:.:.|::
  Fly   294 VVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSLIIVNVVDFVLKIVLAFVWI-MRRSELGPIE 357

Mouse   211 ---------GILLGFFTGI-EVVICALVVVRKDNTSHTYLQYSGVVTWVAMTTQILAAGLGYGLL 265
                     .|......|| .:.||.|...|  ..::.||.::.|.|||....|        |.:
  Fly   358 SDDGTSMATAITWSVCCGIANMAICFLGYWR--CFANNYLHWAAVCTWVLFNIQ--------GFV 412

Mouse   266 GDGIG---------YVLFTLFATYSMLPLPLTWAILAGLGTSLLQVTLQVLI----------PRL 311
            |.|:|         |:||.:|..|:||||||.|.::.|..|:...:.:..:|          |..
  Fly   413 GQGVGFADREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKLQHGEATINPEC 477

Mouse   312 AVFSINQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVL 376
            .:|   |:.|..:|:..:|.||::..||:||.||.||:||.:.:|.:...|.|.||.::|:.|:|
  Fly   478 VLF---QIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRTQKLLDSIL 539

Mouse   377 PRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELF 441
            |..|..::.::|....|..::.||:::|::..:||||||||:||||.|::..|||:||::||:||
  Fly   540 PNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQLVKILNDLF 604

Mouse   442 ARFDRLAHEHHCLRIKILGDCYYCVSGLP----EPRRDHAHCCVEMGLSMIKTIRFVRSRTKHDV 502
            |||||:|.::||||:|:|||||||||...    :.|.|||.|.||.||.|||.|:.||..|..|:
  Fly   605 ARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDVRLHTHVDL 669

Mouse   503 DMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGH 567
            :||||||||||:|||||.:||.|||||.||.|||.:||||||||:|||:|||.|||..|.||.|:
  Fly   670 NMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGN 734

Mouse   568 GKERNEFLRKHNIETYLIKQPEE------------------------------------------ 590
            |..|:..|:..|::|||||:.|.
  Fly   735 GGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSG 799

Mouse   591 ---------------------------------------------SLLCLPEDIVKESVSCSDRR 610
                                                         ||..||.  |.|.|:...||
  Fly   800 SIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPN--VVEGVAMDSRR 862

Mouse   611 -------NSGATFTEG------------------------------------------------- 619
                   ..||..|.|
  Fly   863 IRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLII 927

Mouse   620 ------SWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDLRSG 678
                  .|.||:||.|:...::   .|.|....|:.......:.|....|||::.||..|.:.|.
  Fly   928 EDESTTDWIPEIPFKNLNSPED---GLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSN 989

Mouse   679 DKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRLMPMTIQF 743
            .::|||::.|::|.|||.|.|.|:.|:|:::|:||::|.|::.:|:...|.:: ..|...:.|..
  Fly   990 KEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVII-IPRCTRLIICL 1053

Mouse   744 SILIMLHSALVLITTAEDYKCLPLIL------------RKT---C------CWI---------NE 778
            |:..::.:...::..||::..||..|            |:|   |      |.:         :.
  Fly  1054 SVGTVILTFCCVLVMAEEFPGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSS 1118

Mouse   779 TYLAR--------------------------NVIIFASILIN----------------------- 794
            ||:..                          ||.:.|:|..|
  Fly  1119 TYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPS 1183

Mouse   795 --FLGAVLNILWCDFDKSIP----------------LKNLTFNSSAVF---TDI---CSYPEYFV 835
              |:.:.||.|..:....:|                |.||:::.::|.   :|:   |::|||.|
  Fly  1184 DEFVRSTLNALTLNLTPPLPQSHRPYTLTTNGHSVSLSNLSYSDASVMQSSSDVEGQCAHPEYLV 1248

Mouse   836 FTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETIYAGLFLSYDNLNHSGEDF-------- 892
            ||.||.:|:.|..|:|..::|..:.|.|:|.|..|       :.:.:.    ||:.|
  Fly  1249 FTWVLCLVSLATALKLYYLVKALMALAMVAFYTTL-------IMMKFG----SGDSFSLVELSRL 1302

Mouse   893 ---LGTKEASLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILP 954
               ||.:  .|:|:..||:.|.||.:.:|.|:||||:|:.||:.|:..||..|..|:.:::||||
  Fly  1303 GMPLGVQ--MLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERELTNMKSNRALNDTLIKNILP 1365

Mouse   955 SHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDEL 1019
            .|||.::| .|...:||||:.::..||||||||.|.||||: :::| |..|:|:|||||.|||||
  Fly  1366 DHVATYYL-SDEHTDELYSKMHNLCGVMFASIPNFQDFYSE-DIDN-GKACIRILNEIICDFDEL 1427

Mouse  1020 LGEDRFQDIEKIKTIGSTYMAVSGLSPEK-----QQCEDKWGHLCALADFSLALTESIQEINKHS 1079
            |.|.||..:|||||:|:||||.:||:.|.     :..||.   :|.|.:|:.|:.:.::|||..:
  Fly  1428 LEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDS---VCDLVEFAFAMKQKLEEINGDA 1489

Mouse  1080 FNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFA 1144
            ||||:||:||..|.:|:|||||:||.|||||.|||:||||||||.:.|:||||.|..:|..:|:.
  Fly  1490 FNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWRVQVPENTAELLCSRGYT 1554

Mouse  1145 FDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLVQSLNRQRQKQL 1209
            ...||||.|||    :|.:.|:::..:......::.|.|:|....||       |:.|.|||..
  Fly  1555 CVKRGEIAVKG----KGMMTTFYVHPKGISESQLISPVRMPAGIPLA-------QTPNLQRQTS- 1607

Mouse  1210 LNENSNSGII---KSHYNRRTLL--TPSG-PEP 1236
             :..|.|.::   .....|.|.:  ||:| |.|
  Fly  1608 -HHGSFSAVVFGMLQASKRSTAIAGTPTGTPSP 1639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adcy8	NP_033753.2	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..180		42/163 (26%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1..107		19/88 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..33		4/6 (67%)
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	38..40		0/1 (0%)
		Essential for CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	49..51		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..118		15/73 (21%)
		AC_N	<159..398	CDD:292831	80/267 (30%)
		CYCc	364..562	CDD:214485	116/201 (58%)
		Guanylate_cyc	403..587	CDD:278633	116/187 (62%)
		DUF1053	615..709	CDD:283888	32/148 (22%)
		CYCc	942..1146	CDD:214485	109/208 (52%)
		Guanylate_cyc	971..1170	CDD:278633	106/203 (52%)
		Involved in CALM1 interaction. /evidence=ECO:0000250\|UniProtKB:P40146	1107..1249		51/136 (38%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250\|UniProtKB:P40146	1198..1213		5/14 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1221..1249		7/19 (37%)
Ac78C	NP_001262138.1	AC_N	<288..551	CDD:292831	84/276 (30%)
		CYCc	526..729	CDD:214485	116/202 (57%)
		Guanylate_cyc	566..753	CDD:278633	115/186 (62%)
		DUF1053	929..1020	CDD:283888	30/93 (32%)
		CYCc	1353..1554	CDD:214485	109/206 (53%)
		Guanylate_cyc	1381..1576	CDD:278633	106/203 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5053
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37443
Inparanoid	1	1.050	759	1.000	Inparanoid score	I549
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006020
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100296
Panther	1	1.100	-	-	LDO	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4318
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.820