Protein Alignment OSBPL8 and Orp8

DIOPT Version :10

• Sequence 1: XP_047284202.1
• Gene: OSBPL8 / 114882
• HGNCID: 16396
• Length: 925
• Species: Homo sapiens
• Sequence 2: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Alignment Length: 979
• Identity: 429/979 - (43%)
• Similarity: 576/979 - (58%)
• Gaps: 136/979 - (13%)

Human    27 GLADGEPDRTSILPYSEVAEVQETL------------------LGDSKDVLGPSTVVANSDESQL 73
            |....:|..:|:.....:.::|..|                  :|.|...||.|...|:|.....
  Fly    68 GTPHQQPQSSSVPTGGHLLQLQAPLPSAGGGTGAGAVTPSGLSMGASNQSLGVSVGAASSVSGIS 132

Human    74 LTPG-------------KMSQRQGKEAYPTPTKDLHQPSLSPASPHSQGFERGKEDISQNKDESS 125
            :||.             |..:|...:...|........|.||| |.|.|......|   |:|.
  Fly   133 ITPPNSAGLRQSTVFDFKFKRRPSLKVLMTKLPSTDSLSNSPA-PSSPGIANWASD---NRDG-- 191

Human   126 LSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELLSTITDPSVIVMADW 190
                         |.::|.::.::||.:|||.|.|:||||.||||...||::::.||:|||:|||
  Fly   192 -------------NVADKSAADAAKLNRKESYKAQRKNYRREKKRVASELMNSLQDPAVIVLADW 243

Human   191 LKIRGTLKSWTKLWCVLKPGVLLIYKTQ--KNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLE 253
            ||:|||||||||||||||||:|||||:|  |:..|||||:|.:|::|||||||||||||||||||
  Fly   244 LKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLTSCQVIERPSKKDGFCFKLFHPLE 308

Human   254 QSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSSLLKRTMIREGKEHD 318
            |||||.:||..|.:|::.||||::|||.||.|::.|:||||||||:|:||:||.|
  Fly   309 QSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDALELSLRCSALLLR---------- 363

Human   319 LSVSSDSTHVT--FYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDKSDKENDQEHDESDNE 381
             |.||..|..|  :.|    ..|......|.::::.|: ||.|.|:.:|        ..:|:.|.
  Fly   364 -SNSSTGTAPTSSYIG----EPLPVSHETQWSEADYEK-HFNDHDLDAD--------SQNEAPNA 414

Human   382 VM-GKSEESDTDTSERQDDSYIEPEPVEPLKETTYTEQSHEELGEAGEASQTETVSEENKSLIWT 445
            || |...||::|.:|...|..::.:.|    ||:|...:.||.||.||  |.|.::||||||||.
  Fly   415 VMSGLESESESDPAEPAQDDVVDQQCV----ETSYVPFTEEEFGEQGE--QVEELAEENKSLIWC 473

Human   446 LLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPYFRLKKVVKWYLSGFY 510
            ::||||||||||||||||||||||||||||||.|||||.||:|..|::.:.|:|.||:||||.||
  Fly   474 IVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDAFTRMKLVVQWYLSSFY 538

Human   511 KKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAK 575
            ||||||||||||||||.|||.|.|| :.|:|||||||||||||:|||||:||:|||.::.|||||
  Fly   539 KKPKGLKKPYNPILGERFRCYWQHP-SGSRTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAK 602

Human   576 SKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGGTVNITCQKTGYSAIL 640
            |||||||.||:|||.|.:|.|.|||.|..|.|||||||||.||:::||||.:||.|:.|||...|
  Fly   603 SKFYGNSTSAVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLSMELGGKINIECENTGYRTEL 667

Human   641 EFKLKPFLGSSDCVNQISGKLKLGKEVLATLEGHWDSEVFITDKKTDNSEVFWNPTPDIKQWRLI 705
            |||||||||.:|..|.:.||:|||||.|||:.||||.|..:.|.||....|.:....:.:..||.
  Fly   668 EFKLKPFLGGADATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLT 732

Human   706 RHTVKFEEQGDFESEKLWQRVTRAINAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFEL 770
            |:.|..:.|...||::|||||:.||..:||..||:||.||||.||..|::|.:.:......||||
  Fly   733 RYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFEL 797

Human   771 DPLTGEWHYKFADTRPWDPLNDMIQFEKDGVIQTKVKHRT-PMVSVPKMKHKP--------TRQQ 826
            |.. |:|.||:||.||||..||:.|:|....:.|:.:|:: |:|...:|.| |        :|.|
  Fly   798 DSY-GQWLYKYADLRPWDSRNDVRQYECQFKVLTQTRHKSVPIVHGAEMIH-PLRSSIETLSRTQ 860

Human   827 KKVAKGYSSP----------------EPDIQDSSGSEAQSVKPSTRRKKGIELGDIQSSIESIKQ 875
            ::...|...|                .|  :|::...:||.:.:.:|.....:..:..:::.:.:
  Fly   861 RQSPAGQPLPPGGSAVPKAKNKSLVLAP--RDTNSDSSQSPQGAVKRSSSSAIKQLALAVDQVNR 923

Human   876 TQEEIKRNIMALRN-------------------HLVSSTPATDYFLQQKDYFIIFLLILLQVIIN 921
            ..|:..|.:..:..                   |::....:....::...|.:|.|...|  |:.
  Fly   924 VLEQHTRQLNEISQRLERMQYSPPPSSMSAHSLHMLGGGVSQSTVIKSLIYALIGLAFSL--ILR 986

Human   922 FMFK 925
            ::||
  Fly   987 WLFK 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OSBPL8	XP_047284202.1	PH_OPR5_ORP8	178..307	CDD:270103	92/130 (71%)
		Oxysterol_BP	443..789	CDD:460126	216/345 (63%)
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	91/129 (71%)
		Oxysterol_BP	471..817	CDD:460126	217/347 (63%)