DRSC/TRiP Functional Genomics Resources

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Protein Alignment OSBPL8 and CG3860

DIOPT Version :10

Sequence 1:XP_047284202.1 Gene:OSBPL8 / 114882 HGNCID:16396 Length:925 Species:Homo sapiens
Sequence 2:NP_001286802.1 Gene:CG3860 / 37825 FlyBaseID:FBgn0034951 Length:457 Species:Drosophila melanogaster


Alignment Length:461 Identity:128/461 - (27%)
Similarity:193/461 - (41%) Gaps:116/461 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   426 AGEASQTE---TVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSE 487
            |....:||   |:....:..||.:||.. .|.||||:.:|..:.||.|||.:|.:|..:|..|:|
  Fly     7 AEHVERTELPATMISRKEVSIWAILKNC-IGKDLSKITMPVMLNEPLSFLQRLCEYMEYAQLLTE 70

Human   488 AALEENPYFRLKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFY--IAEQVSH 550
            ||.:|:|..|:|.|..:.:|......:.|.||:||:||||:..        .|..|  :.|||||
  Fly    71 AAQQEHPADRMKYVAAFAVSALASNWERLGKPFNPLLGETYEL--------QKGDYRIVCEQVSH 127

Human   551 HPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGIL 615
            |||:|||:..: || |...|:|..|.||:|.|:....:|...:.|....|.|..|........|:
  Fly   128 HPPVSAFHAES-KD-FKFHGTISPKIKFWGKSVEVNPKGTVTVEFPKWNESYSWTNVNCCVHNII 190

Human   616 YGTMTLELGGTVNITCQKTGYSAILEFKLKPFLGS-SDCVNQISGKLKLGKEV-LATLEGHW--- 675
            .|.:.:|..|.:.||...||:.|.|.||   ..|| :..::::.|.:|...|. |..|.|.|   
  Fly   191 VGRLWIEQYGKMEITNHATGHVASLTFK---SAGSGAKNLHRVEGFVKDASETNLYFLYGKWTEF 252

Human   676 ----DSEVFIT-----DKKTDNSEVFWNPTP-----DIKQWRL-------IRHTVK-----FEEQ 714
                .:|.::.     .:|.|:.:...|.||     .:..::|       |:....     .|::
  Fly   253 IKCCSAESYVQFLKQGTRKNDDYDGSPNGTPKKMFSKLNSFKLNSFRSLSIQDVSSDSYPPMEQE 317

Human   715 GDF------------ESEKLWQRVTR---------------AINAKDQT---------------- 736
            ||.            :|..||....|               .:||.|..                
  Fly   318 GDIPKSDSAYSLDIPDSTTLWSCKPRPSNCSEYYQFTHFALQLNAMDSNMKPPLTLCPTDSRLRP 382

Human   737 -----------EATQEKYVLEEAQRQAARDRK-TKNEEWSCKLFE--LDPLT---------GEWH 778
                       .|::||..|||.||...:.|| |.:::||.:.|:  .:|.|         |.|.
  Fly   383 DILHLEEGNLDGASKEKTRLEEKQRHTRKQRKSTNSDDWSPRWFKYATNPHTKIDDWLYSGGYWD 447

Human   779 YKFADT 784
            .|:.:|
  Fly   448 RKYDNT 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OSBPL8XP_047284202.1 PH_OPR5_ORP8 178..307 CDD:270103
Oxysterol_BP 443..789 CDD:460126 124/441 (28%)
CG3860NP_001286802.1 Oxysterol_BP 26..450 CDD:460126 122/437 (28%)
Blue background indicates that the domain is not in the aligned region.

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