Protein Alignment OSBPL8 and CG1513

DIOPT Version :10

• Sequence 1: XP_047284202.1
• Gene: OSBPL8 / 114882
• HGNCID: 16396
• Length: 925
• Species: Homo sapiens
• Sequence 2: NP_610534.3
• Gene: CG1513 / 36028
• FlyBaseID: FBgn0033463
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 765
• Identity: 207/765 - (27%)
• Similarity: 318/765 - (41%)
• Gaps: 199/765 - (26%)

Human   193 IRGTLKSWT---KLW----CVLKPGV-LLIYKTQKN----GQWVGTVLLNACEIIERPSKKDG-- 243
            :.|||..||   |.|    .||.... ||.|.|.|:    |...|.|.|... :|....::|.
  Fly    24 LEGTLSKWTNVMKGWQYRFFVLDENAGLLSYYTSKDKMIKGVRRGCVRLKDA-LIGIDDQEDNTF 87

Human   244 --------FCFKLFHPLEQSIWAVK-------------------------GPKGEAVGSITQPLP 275
                    |.|:..|..|:..|..:                         |...|..||.|....
  Fly    88 TITVDHKTFHFQARHNEEREQWVRRLEDTIRRHANRSRLWDSQSAFYIAGGYTKEGGGSGTGGRR 152

Human   276 SSY--LIIRATSESDGRCWMDALELAL--------------------KCSSL----------LKR 308
            .::  |:.|..||:|.     .|:|.:                    ||.:|          :|.
  Fly   153 PNHLELVARRVSEADA-----YLQLMIEQTNLLDKRIAELTDPAEQSKCKALQDNANAMLDHIKH 212

Human   309 TM----IREGKEHDL--------SVSSDSTHVTFYGLLRANNLHSGD-NFQLNDSEIERQHFKDQ 360
            ::    |.:...|.:        :.:|.|:..:...:...||:.:|. ...|....|.:....|.
  Fly   213 SIVSLQIAKNMAHPINGIYNGPPATASTSSSTSGVAMGSCNNVQAGGLKVPLEGQVIGKGELVDD 277

Human   361 D--------------------MYSDKSDKENDQEHDESDNEVMGKS---------EESDTDTSER 396
            :                    .||....:|:..:..:.....:|.|         .|:.:.|.|:
  Fly   278 EEDSATENATTAPLGLIVPATSYSSSEGEEDFYDAYDDPFTSIGSSPIGCATRGFAETTSPTHEK 342

Human   397 QDDSYIEPEPV--------EPLKE----------------TTYTEQS--------HEELGEAGEA 429
            ..|.:...|||        :.|.|                |..:.:|        ::.|.|  |.
  Fly   343 APDGFANAEPVAVGDSVAPQTLPEIDESVADADTSIKTARTAVSSRSASYDNGIDYDALYE--EE 405

Human   430 SQTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENP 494
            .:|:...|.:.|:|..||.||:.||||:||||||||||.||.|:..:||:.|.|...:.:..::|
  Fly   406 EETDLSMEAHGSMITHLLSQVKIGMDLTKVVLPTFILERRSLLEMYADYFAHPDLFIKISDLDDP 470

Human   495 YFRLKKVVKWYLSGFY--KKPKGLKKPYNPILGETFRCLWIHP-----------------RTNSK 540
            ..|:.:|.:||:|.::  :|....||||||||||.|:|.|..|                 |.:..
  Fly   471 RDRIVQVCRWYMSAYHAGRKSAVAKKPYNPILGEVFQCHWDIPGISQDAQEVRDGPVPWCRRDQL 535

Human   541 TFYIAEQVSHHPPISAFYVSNRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMT 605
            || :||||||||||||||..:.......:..:..||||.|.|:.....||..:|.::|.|:|::|
  Fly   536 TF-LAEQVSHHPPISAFYAEHYNKKITFAAHVWTKSKFLGLSIGVHNIGEGVVTLVDRSEEYIVT 599

Human   606 MPYAHCKGILYGTMT-LELGGTVNITCQKTGYSAILEFKLKPFLGSSDCVNQISGKL--KLGKEV 667
            .|..:.:.||  |:. :||||:|.|.|.::||.|.:||..|||.|...  |::|.::  ...|:.
  Fly   600 FPNGYGRSIL--TVPWIELGGSVEIKCPQSGYYANVEFLTKPFYGGKR--NRVSAEVYAPSEKKP 660

Human   668 LATLEGHWDS--EVFITDKKTDNSEVFWNPTPDIKQWRLIRHTVK-FEEQGDFESEKLWQRVTRA 729
            ..::.|.|..  |....||  :.:|||    .|:.:..:.:..|: ..||.::||.::|:.||..
  Fly   661 FVSITGEWSGLMEAKWHDK--NKTEVF----VDVNRIPIFKKQVRPIVEQDEYESRRVWKEVTAG 719

Human   730 INAKDQTEATQEKYVLEEAQRQAARDRKTKNEEWSCKLFELDPLTGEWHY 779
            :...|...||..|:|:|:.||..|:.||..:..|..|.|:  |:...|.|
  Fly   720 LKFNDIERATTAKFVVEQQQRDQAKVRKEYDLAWEHKHFK--PVGDNWIY 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OSBPL8	XP_047284202.1	PH_OPR5_ORP8	178..307	CDD:270103	40/192 (21%)
		Oxysterol_BP	443..789	CDD:460126	134/362 (37%)
CG1513	NP_610534.3	PH_ORP9	24..125	CDD:241444	25/101 (25%)
		Oxysterol_BP	421..767	CDD:460126	132/358 (37%)