Protein Alignment SMYD4 and Smyd4-2

DIOPT Version :10

• Sequence 1: NP_443160.2
• Gene: SMYD4 / 114826
• HGNCID: 21067
• Length: 804
• Species: Homo sapiens
• Sequence 2: NP_648574.1
• Gene: Smyd4-2 / 39414
• FlyBaseID: FBgn0036282
• Length: 663
• Species: Drosophila melanogaster
• Alignment Length: 837
• Identity: 174/837 - (20%)
• Similarity: 285/837 - (34%)
• Gaps: 260/837 - (31%)

Human     6 DEW-KSYL--LQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELF----LKRLSKGYLVGK 63
            |:| ::|.  |:..|:...|:.......:.:..:..|...:.:.:|.||    ..:..|.||:..
  Fly    37 DKWLRNYFGKLKSNAARVLSIFSDREVCDPVLGVLEHVQPVFKQKDALFSAQRRAQADKLYLMSG 101

Human    64 DSDAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHSRPNTED--------MSLCHANRSAALFHLG 120
            ..|.     ||..:..|:     |.:..:..|..:.....|        ::|.:.:|::.|..||
  Fly   102 SGDG-----EESRELLQQ-----ALMAANLAVMRAPDRNADPVLDEGLTLALAYRSRASILIRLG 156

Human   121 QYETCLKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALADVLP- 184
            :.|..|.|:..|...|...:......|:.|:....:|....|..::.           :|:.:|
  Fly   157 EGEAALNDLKLAINFGLELKSSVDYYLKMAKAYAVMGEPARAEISLK-----------IAEKMPG 210

Human   185 ------QTLQRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIGLCVDPLK 243
                  ...::.|..:|.|  .|::.:|..| .||        ..|:.:|..||..:.|.....|
  Fly   211 CDATHIALCRKELSSVKPK--PKEATSEQVP-QLA--------HGESAELVGASKVVRLVETKDK 264

Human   244 GRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATVP 308
            ||.:||.:.:..|::|:.|:...:.|.|           |.:.|       :||.|.|.....|.
  Fly   265 GRFVVANEGLRTGDVLLFEEPVAACLEP-----------SYFGT-------HCHHCFKRLHTPVS 311

Human   309 CDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLG--VFCHIALRLTLLVGFEDVRKIITKLC 371
            |..||...:||.:|:.:|...|||.||....|::..|  :.|.||||:.
  Fly   312 CLHCSGIAFCSAQCMGEACSSYHRFECEYMDLMIGSGMSILCFIALRIF---------------- 360

Human   372 DKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVF-NLLPHTENH 435
                          .|..:|..||..:                        |.:| :|..|.|:.
  Fly   361 --------------TQAPSLEQGLATA------------------------NLLFEHLCSHEEDR 387

Human   436 SPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQ 500
            .|:.....||....|.|.|:.:..........||.:.::..|           ..|:|..:..||
  Fly   388 QPDDYLRRALMSGFLLRILQKSLYFGRRKTEGVNPTAVELQV-----------ATALLGLLQVLQ 441

Human   501 CNA----QAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQ 561
            .||    |...|.:|.      ...|:.|.||.|::...|..||.|.|:|:..|:.....:.|::
  Fly   442 YNAHQIYQTQVTEEHR------FDGSKTVYLAAGLYGTGSYFNHECWPSTACHFVGKKLVLTATR 500

Human   562 RIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWEAFCCNSCGAP 626
            ..|..:.:...|||...:..:.|||:.||.:|.|.|:|.|||         ..|...
  Fly   501 PHRANELVAVNYGPIFIKNNLKERQRSLRGRYSFSCSCMACQ---------ENWPLL-------- 548

Human   627 MQGDDVLR--CGSRSCAESAVSRDHLVSRLQDLQQQVRVAQ------------KLLRDGELERAV 677
            .:.|..:|  |.|.:|:       :|:...:||.:.||..:            |:::..||.|..
  Fly   549 QKLDKQVRFWCTSANCS-------NLLKFPKDLAKDVRCPRCRKNISLKESVAKMIKIEELYREA 606

Human   678 QRLSGCQRDAESFLWAEHAVVGEIADGLARACAALGDWQKSATHLQRSLYVVEVRHGPSSVEMGH 742
            .|....|:..|:.
  Fly   607 ARAMEAQKTVEAI---------------------------------------------------- 619

Human   743 ELFKLA-QIFFNGFAVPEALSTIQKAEEVLSLHCGPWDDEIQELQKMKSCLLDLPPT 798
            ||||.: .:||...|:|.                   .|.|...|.:..||.|...|
  Fly   620 ELFKESLDMFFQVAALPH-------------------KDTIVAQQSLHKCLSDTGTT 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMYD4	NP_443160.2	NlpI	<66..>171	CDD:443815	21/112 (19%)
		TPR repeat	68..96	CDD:276809	4/27 (15%)
		TPR repeat	101..135	CDD:276809	10/41 (24%)
		TPR repeat	143..171	CDD:276809	4/27 (15%)
		SET	239..>269	CDD:394802	8/29 (28%)
		zf-MYND	296..335	CDD:460312	15/38 (39%)
		SET_SMYD4	404..602	CDD:380934	49/202 (24%)
		TPR_12	660..726	CDD:315987	9/77 (12%)
		TPR_12	698..771	CDD:315987	8/73 (11%)
Smyd4-2	NP_648574.1	BepA	87..205	CDD:443813	24/138 (17%)
		SET_SMYD4	249..541	CDD:380934	93/380 (24%)
		zf-MYND	299..338	CDD:460312	15/38 (39%)