Protein Alignment SMYD4 and SmydA-6

DIOPT Version :10

• Sequence 1: NP_443160.2
• Gene: SMYD4 / 114826
• HGNCID: 21067
• Length: 804
• Species: Homo sapiens
• Sequence 2: NP_611182.1
• Gene: SmydA-6 / 36917
• FlyBaseID: FBgn0034183
• Length: 498
• Species: Drosophila melanogaster
• Alignment Length: 626
• Identity: 127/626 - (20%)
• Similarity: 211/626 - (33%)
• Gaps: 238/626 - (38%)

Human   244 GRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATVP 308
            ||..||..::..||.|:.|:..|      .||              ..|:..|.:|
  Fly    21 GRFAVALCNVRAGETLLLENPIV------VLP--------------LMGERRCSKC--------- 56

Human   309 CDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDVRKIITKLCDK 373
                                 ::.||.           ||.   :..||...||......:.|.:
  Fly    57 ---------------------FNLTES-----------FCR---KCRLLALCEDCSDHDERDCKR 86

Human   374 ISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENHS-- 436
            ::..:.    |::||:.|       :|..:....|:..|.:..::|..       ||..|..|
  Fly    87 LAEMNF----SDDQVELL-------QKKEHTEIQPVLKCLLLREHEET-------LPLYEEMSQM 133

Human   437 ----------------PEHKFLCALCVSALCRQLEAAS----LQAIPTERIVNSSQLKAAVTPEL 481
                            .||.| ..|....:..||..|:    :|.:.....:|:.:::|
  Fly   134 DSQLMTRRGTEVWKNYQEHAF-TPLDYGGVLAQLRGAADEDLVQGLLGILDINAYEIRA------ 191

Human   482 CPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNT 546
             |:|   |.||                                    .|::....|..|||:||.
  Fly   192 -PEV---GGAM------------------------------------RGLYRRAGLFAHSCTPNL 216

Human   547 SVSFISTVATIR--ASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQ--TEAH 607
            .:| |.....|:  |::.|..|:.:.:||  ....:|..||::.|:....|||:||.||  ||
  Fly   217 VIS-IDDEQRIKVYANRFIAAGEILYNCY--TNVLLGTEERRKILKVGKCFDCSCPRCQDPTE-- 276

Human   608 RMAAGPRWEAFCCNSCGA----------------------PMQGDDVLRCGSRSCAESAVSRDHL 650
               .|....:|.|:.|..                      .::.:.|.....|:..|...:||.:
  Fly   277 ---LGTHMSSFICSQCSCVDGYIVRQPDTGIWQCLLNPEHTLKQEFVSNMLERAKEEIFHARDDI 338

Human   651 ---------VSRL--------QDLQQQV-RVAQKLLRD-------GELERAVQRLSGCQRDAESF 690
                     :|||        .||:|.: .:.:::|::       ...||.: ||  ||   |..
  Fly   339 YRQELLLAKLSRLLHRNHFLMLDLKQNIASILRQILQNMGTRPNKKVYERKI-RL--CQ---EIL 397

Human   691 LWAEHAVVGEIADGLARACA-ALGDWQKSATHLQRSLYVVEVRHGPSSVEMGHELFK-------- 746
            |     |:..:..|::|..| ||.:...:...|.|.:| .|:.|  |:.::..||.:
  Fly   398 L-----VLKVVTPGISRLKAIALYELANTQAELARKMY-TEMEH--SANDLLAELERVEVMLRES 454

Human   747 LAQIFFNGFAVPEALSTIQKAEEVLSLHCGPWDDEIQELQK 787
            |..:.|...|.||...|.....|:..|     .|:|:.|::
  Fly   455 LRMLLFEPLATPEGQLTRSMLRELKEL-----QDDIKNLRE 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMYD4	NP_443160.2	NlpI	<66..>171	CDD:443815
		TPR repeat	68..96	CDD:276809
		TPR repeat	101..135	CDD:276809
		TPR repeat	143..171	CDD:276809
		SET	239..>269	CDD:394802	9/24 (38%)
		zf-MYND	296..335	CDD:460312	3/38 (8%)
		SET_SMYD4	404..602	CDD:380934	46/221 (21%)
		TPR_12	660..726	CDD:315987	17/74 (23%)
		TPR_12	698..771	CDD:315987	20/81 (25%)
SmydA-6	NP_611182.1	SET_SMYD	<185..271	CDD:380997	31/134 (23%)