Protein Alignment SMYD4 and SmydA-7

DIOPT Version :10

• Sequence 1: NP_443160.2
• Gene: SMYD4 / 114826
• HGNCID: 21067
• Length: 804
• Species: Homo sapiens
• Sequence 2: NP_611181.1
• Gene: SmydA-7 / 36916
• FlyBaseID: FBgn0034182
• Length: 488
• Species: Drosophila melanogaster
• Alignment Length: 596
• Identity: 123/596 - (20%)
• Similarity: 193/596 - (32%)
• Gaps: 187/596 - (31%)

Human   221 LREENEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKW 285
            ::|..|.:.:|.       |...||.|||:..|.||:.:::|...        |..||      |
  Fly     1 MQEFGENIQHAH-------DEKLGRHLVASIAIEPGDTILEERPL--------LVAPH------W 44

Human   286 DTRVTNGDLYCHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHI 350
            :..    .|.|.:||:.:.  |.|..|.....| .:|.|     :...||
  Fly    45 ECH----QLKCAQCLQESY--VICRRCQVFPLC-MDCNQ-----HDEFEC--------------- 82

Human   351 ALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDIN 415
                          :..|....|...|||.:.         |:|:....|...::|.|    ...
  Fly    83 --------------EFFTSGAGKALCKDILVK---------NFGICGLLKLLLLLENP----RTK 120

Human   416 GKYENNYNAVFNLLPHTENHS--PEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVT 478
            |..:...:...||..:.:...  .||:   .|.|..|   :|:.....:||:
  Fly   121 GDCQMLIDVPINLSDYRDGEGMWQEHE---ELVVRPL---MESGLADVLPTQ------------- 166

Human   479 PELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCS 543
             ||..|      |:..|.:::..|     :.:.|...|..:         .|||...:.|.|.|.
  Fly   167 -ELTSD------ALHAHCIRIDSN-----SFEVTAKDGDTL---------KGIFVWGATLPHHCV 210

Human   544 PNTSVSFISTV-ATIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC--QTE 605
            |||.|:..... ..:.|:..::.|..|.:.|  ....||.::||.:||.....:|.|..|  .||
  Fly   211 PNTVVALDEQFNMKLYAAVPLQPGDIIYNSY--TNPLMGTSQRQHQLRLSRRLECICSRCLDPTE 273

Human   606 AHRMAAGPRWEAFCCNSCG--APMQGDDVLRCGSRSCAE-------------SAVSRDHLVSRLQ 655
                 .|....:..|..|.  :..:.|...:.|...|.:             .|.....||..:.
  Fly   274 -----MGTHMSSLKCKECPGFSVCEIDSNGKLGDWRCPDCRALLTAAEVHELQAAVGSALVDAMG 333

Human   656 DLQQQVRVAQKLLRD-GELERAVQRLSGCQRDAESFLWAEHAVVGEIADGLA---RACAALGDWQ 716
            |||    |.:.||.. |.|                 |...|.::.:|...:|   ||.|.:....
  Fly   334 DLQ----VYEALLTQYGPL-----------------LHPNHFMLLDIKQNIASILRAAALMNSMD 377

Human   717 KSATHLQRSLYVVEVRHGPSSVEMGHELFKLAQIFFNGFAVPEALSTIQKAEEVLSLHCGPWDDE 781
            :....|.           ...||:..:|..:.:....|.:   .|..|...|.:|:|      .|
  Fly   378 QPCKKLL-----------ARRVELCSDLLPVCRAVVPGIS---KLYAIGLFEYLLAL------VE 422

Human   782 IQELQKMKSCL 792
            :.|||..:|.|
  Fly   423 LVELQFAESDL 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMYD4	NP_443160.2	NlpI	<66..>171	CDD:443815
		TPR repeat	68..96	CDD:276809
		TPR repeat	101..135	CDD:276809
		TPR repeat	143..171	CDD:276809
		SET	239..>269	CDD:394802	10/29 (34%)
		zf-MYND	296..335	CDD:460312	9/38 (24%)
		SET_SMYD4	404..602	CDD:380934	43/200 (22%)
		TPR_12	660..726	CDD:315987	13/69 (19%)
		TPR_12	698..771	CDD:315987	13/75 (17%)
SmydA-7	NP_611181.1	SET_SMYD	<178..268	CDD:380997	25/105 (24%)