Protein Alignment SMYD4 and SmydA-1

DIOPT Version :10

• Sequence 1: NP_443160.2
• Gene: SMYD4 / 114826
• HGNCID: 21067
• Length: 804
• Species: Homo sapiens
• Sequence 2: NP_610944.1
• Gene: SmydA-1 / 36581
• FlyBaseID: FBgn0033917
• Length: 513
• Species: Drosophila melanogaster
• Alignment Length: 465
• Identity: 102/465 - (21%)
• Similarity: 152/465 - (32%)
• Gaps: 158/465 - (33%)

Human   225 NEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRV 289
            ||||               ||.||||:.|.|.|::::|...|.  .|.::..|
  Fly    48 NEQL---------------GRHLVATRTIKPYEIVLKEAPLVR--GPAQISAP------------ 83

Human   290 TNGDLYCHRCLKHTLAT--VPCDGCSYAKYCSQEC--LQQAWELYHRTECPLGGLLLTLGVFCHI 350
                 .|..||....|.  :.|:.|.: ..|..||  |.:     |:.||   ||....|...::
  Fly    84 -----VCLGCLNGIEAEDHIECEQCGW-PLCGPECKSLDE-----HKAEC---GLTKDRGQKVNV 134

Human   351 ALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDIN 415
            .       .|.....:.|           ||    :.|:.|..|...:||              .
  Fly   135 Q-------EFGGPHPLYT-----------CL----STVRCLLIGETSTEK--------------A 163

Human   416 GKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASL-QAIP----TERIVNSSQLKA 475
            .|:::     ...|..|...|.:.|             .:..|: |.||    |::......:||
  Fly   164 SKFQD-----LESLESTRRGSNQWK-------------ADLVSIGQFIPKFFKTQKFTEEEIMKA 210

Human   476 AVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNH 540
            ...                    ||.|...:.|           ||...|    .:|...|...:
  Fly   211 VGA--------------------LQINGHEVPT-----------TDPSHV----AVFYTASFTEN 240

Human   541 SCSPNTSVSFISTVATIR-ASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC-- 602
            ||.||.:.||......|. |.:.|:|...:..||.  .:..|.|:||:.|.....|.|||..|
  Fly   241 SCLPNLAKSFNKNGHCILWAPREIKKNAHLSICYS--DAMWGTADRQRHLMQTKLFKCACERCVD 303

Human   603 QTEAHRMAAGPRWEAFCCNSCGAPMQGDD---VLRCGSRSCAESAVSRDHLVSRL-----QDLQQ 659
            .||.....:..:.|...|.....|.:.|:   ..||  |.|.:..  :.|.|.|:     :|:|.
  Fly   304 VTELDTNYSAIKCEDRQCGGLMLPTKADEWNGSWRC--RECHKQV--QKHYVERILERAGKDIQS 364

Human   660 QVRVAQKLLR 669
            ..::|:..|:
  Fly   365 MEKIAENGLK 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMYD4	NP_443160.2	NlpI	<66..>171	CDD:443815
		TPR repeat	68..96	CDD:276809
		TPR repeat	101..135	CDD:276809
		TPR repeat	143..171	CDD:276809
		SET	239..>269	CDD:394802	11/29 (38%)
		zf-MYND	296..335	CDD:460312	11/42 (26%)
		SET_SMYD4	404..602	CDD:380934	42/203 (21%)
		TPR_12	660..726	CDD:315987	2/10 (20%)
		TPR_12	698..771	CDD:315987
SmydA-1	NP_610944.1	zf-MYND	4..40	CDD:460312
		SET_SMYD	<217..301	CDD:380997	28/100 (28%)