DRSC/TRiP Functional Genomics Resources

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Protein Alignment SMYD4 and Smyd4-3

DIOPT Version :10

Sequence 1:NP_443160.2 Gene:SMYD4 / 114826 HGNCID:21067 Length:804 Species:Homo sapiens
Sequence 2:NP_725048.1 Gene:Smyd4-3 / 36234 FlyBaseID:FBgn0033633 Length:660 Species:Drosophila melanogaster


Alignment Length:651 Identity:161/651 - (24%)
Similarity:267/651 - (41%) Gaps:131/651 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    62 GKDSDAPLFYREEGNKKFQEKDYTGAAVLYSKG-VSHSRPNTEDMSLCHANRSAALFHLGQYETC 125
            ||::......:|.....|:.|.:..|.:||::. |:....|..::.:..|||||.|:|:.:|:.|
  Fly    68 GKNASLAAEIKERATSAFKAKKWLEAMMLYTRSYVALPSENVAEIRVVLANRSATLYHMQKYQEC 132

Human   126 LKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALADVLPQTLQRN 190
            |.||.||....|.:.|..|:..|:|.|.:|   |::...||...::..||.........:..:.|
  Fly   133 LIDIKRALDLSYSKDLIYKLYERQARCYMA---LKDYPHTIDSFKKCITAMDDSTLASDKRAKLN 194

Human   191 LHRLKM-KMQEKDSLTESFPAALAK---TLEDA-ALREENEQLSNASSSIGLCVDPL-------- 242
            |..:.| ||.:.|..|....|...|   .|:.| .::.|||           .|.||        
  Fly   195 LDAMTMIKMLQNDPRTAKQEAKQQKQKIALDQAKPVKLENE-----------FVSPLVRIDSNRQ 248

Human   243 KGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATV 307
            :||...|:.|:.|||.|:.|..|||||           |:....|       :|..|...|:..|
  Fly   249 EGRFARASADVKPGEELLVERPFVSVL-----------LEKFAKT-------HCENCFMRTVVPV 295

Human   308 PCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLG--VFCHIALRLTLLVGFEDVRKIITKL 370
            .|..|:...|||::|.::|.:.||:.||.:..::...|  :..|||||:......:...|:...:
  Fly   296 ACPRCADVLYCSEQCREEASKKYHKYECGIVPIIWRSGASINNHIALRIIASKPLDYFLKLKPTI 360

Human   371 CDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENH 435
            .::::      ||                   .::..|          ::::..|..|..|....
  Fly   361 DEELT------PE-------------------QLISLP----------KDDFRRVAQLERHQGER 390

Human   436 SPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPD-VTIWGVAMLRHMLQL 499
            .|.:.|...|....|...|.|..         ...|:.|        || |:|....:||.:..:
  Fly   391 QPSNFFQHVLMARFLTNCLRAGG---------YFGSEPK--------PDEVSIICSLVLRSLQFI 438

Human   500 QCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIR 564
            |.|...:..:......|.    .:.:.:...|:|.::|.||||.|.....|..|...|.:.:.|.
  Fly   439 QFNTHEVAELHKFSSSGR----EKSIFIGGAIYPTLALFNHSCDPGVVRYFRGTTIHINSVRPIE 499

Human   565 KGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWE-------AFCC-- 620
            .|..|...|||..::...:|||.:|:..|:|:|:|.||      :...|:::       .|.|  
  Fly   500 AGLPINENYGPMYTQDERSERQARLKDLYWFECSCDAC------IDNWPKFDDLPRDVIRFRCDA 558

Human   621 -NSCGA-----PMQGDDVLRCGSRSCAE-SAVSRDHLVSRLQDLQQQVRVAQKLLRDGELERAVQ 678
             |:|.|     |...|.:::|  .:|.| :.:.:...|  :||.:...|.|::|...||..:|:.
  Fly   559 PNNCSAVIEVPPSCNDFMVKC--VTCGEITNILKGLKV--MQDTEMMTRTAKRLYETGEYPKALA 619

Human   679 R 679
            :
  Fly   620 K 620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SMYD4NP_443160.2 NlpI <66..>171 CDD:443815 32/105 (30%)
TPR repeat 68..96 CDD:276809 6/28 (21%)
TPR repeat 101..135 CDD:276809 15/33 (45%)
TPR repeat 143..171 CDD:276809 8/27 (30%)
SET 239..>269 CDD:394802 15/37 (41%)
zf-MYND 296..335 CDD:460312 13/38 (34%)
SET_SMYD4 404..602 CDD:380934 46/198 (23%)
TPR_12 660..726 CDD:315987 6/20 (30%)
TPR_12 698..771 CDD:315987
Smyd4-3NP_725048.1 TPR repeat 74..103 CDD:276809 6/28 (21%)
TPR repeat 108..142 CDD:276809 15/33 (45%)
TPR repeat 150..177 CDD:276809 8/29 (28%)
SET_SMYD4 235..537 CDD:380934 90/386 (23%)
zf-MYND 284..323 CDD:460312 13/38 (34%)
Blue background indicates that the domain is not in the aligned region.

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