Protein Alignment SMYD4 and SmydA-3

DIOPT Version :10

• Sequence 1: NP_443160.2
• Gene: SMYD4 / 114826
• HGNCID: 21067
• Length: 804
• Species: Homo sapiens
• Sequence 2: NP_609464.1
• Gene: SmydA-3 / 34502
• FlyBaseID: FBgn0262599
• Length: 507
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 110/501 - (21%)
• Similarity: 163/501 - (32%)
• Gaps: 178/501 - (35%)

Human   241 PLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLA 305
            |:.||.|||...|....||::|..|  .:.|                 ..||.:.|..|.:..
  Fly    18 PVCGRYLVAKGAIRGHGLLIEELPF--AVGP-----------------KCNGPVVCLGCYEPN-- 61

Human   306 TVP------CDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDVR 364
              |      |..|.: ..| .||.|||...:.|.||.                      ..:|.|
  Fly    62 --PDPEEELCSECGW-PLC-VECAQQADNAHFRLECS----------------------QLKDAR 100

Human   365 KIITKL------CDKISNKDICLP-------ESN-----NQVKTLNYGLGESEKNGNIVETPIPG 411
            ....:|      |.::   |..:|       |:|     |:|..:.:...|.:::.::
  Fly   101 ARFFRLPSGSRHCPQL---DCIMPLRVLLAKEANPERWDNEVAPMEHHKEERQRDADV------- 155

Human   412 CDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAA 476
                 .:.:..|..              ::|...|                         ||...
  Fly   156 -----WHADRVNIA--------------QYLRGPC-------------------------QLANR 176

Human   477 VTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHS 541
            .:.||...|.  ||        |:.||     .:...|||      ..:|.   :||...:|.|:
  Fly   177 FSEELIMQVV--GV--------LEVNA-----FEARSPKG------YPLRC---LFPYTGILAHN 217

Human   542 CSPNTSVSFISTVA---TIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPAC- 602
            |.||||.|...:..   .:||...:.:||.:.|.|  ..:..|.|:||:.|:...||.|.|..|
  Fly   218 CVPNTSRSIYPSEGYKIRLRAMVDLEEGQPLHHSY--TYTLDGTAQRQKHLKQGKFFTCQCERCL 280

Human   603 -QTEAHRMAAGPRWEAFCCNSCG-------APMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQ 659
             .||     .|..:.:..|..|.       .|.:.|....|.  :|.....:.|.| :.||.||.
  Fly   281 DPTE-----LGTHFSSLKCGQCAEGFQVPRQPTEPDTSWNCA--NCGSDTSNADAL-AMLQSLQS 337

Human   660 QVRVAQKLLRDGELERAVQRLSGCQRDAESFLWAEHAVVGEIADGL 705
            :|...|.|....:....::||   .|..:|.|...|.    ||.||
  Fly   338 EVNAVQALPMAAKRLEEIERL---LRKYKSLLHPLHF----IATGL 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMYD4	NP_443160.2	NlpI	<66..>171	CDD:443815
		TPR repeat	68..96	CDD:276809
		TPR repeat	101..135	CDD:276809
		TPR repeat	143..171	CDD:276809
		SET	239..>269	CDD:394802	11/27 (41%)
		zf-MYND	296..335	CDD:460312	12/44 (27%)
		SET_SMYD4	404..602	CDD:380934	42/200 (21%)
		TPR_12	660..726	CDD:315987	13/46 (28%)
		TPR_12	698..771	CDD:315987	4/8 (50%)
SmydA-3	NP_609464.1	SET_SMYD	<192..279	CDD:380997	31/102 (30%)