Protein Alignment SMYD4 and SmydA-4

DIOPT Version :10

• Sequence 1: NP_443160.2
• Gene: SMYD4 / 114826
• HGNCID: 21067
• Length: 804
• Species: Homo sapiens
• Sequence 2: NP_572675.1
• Gene: SmydA-4 / 32034
• FlyBaseID: FBgn0030257
• Length: 532
• Species: Drosophila melanogaster
• Alignment Length: 656
• Identity: 133/656 - (20%)
• Similarity: 204/656 - (31%)
• Gaps: 240/656 - (36%)

Human   188 QRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIGLCVDPLKGRCLVATKD 252
            ||...:.|.|.:::|......|.            ||.|.......|      .:.||.|||.:.
  Fly    20 QRGGQQSKDKQEQQDKEQSPSPT------------EEKELPYRVEHS------DIYGRYLVANRQ 66

Human   253 ILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLA----TVPCDGCS 313
            :..||.|::|:       |..:.|            ..:||..|..|. |.::    ...|.||:
  Fly    67 LEAGETLIREE-------PLAIGP------------CVSGDPVCLGCY-HPVSLKADQYRCPGCA 111

Human   314 YAKYCSQECLQQAWELYHR-----TECPL-------GGLLLTLGVFCHIALRLTLLVGFEDVRKI 366
            : ..|...|.    .|.||     |||.|       .|.|            ||...|..:||.
  Fly   112 W-PLCGSTCA----GLKHRHGHTETECQLYAERRAVAGEL------------LTERAGPAEVRD- 158

Human   367 ITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPH 431
                          |.|....|:.|.....:.|:                         |.|:..
  Fly   159 --------------LYELVMIVRILLLRQHDPEQ-------------------------FALIAR 184

Human   432 TENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIV-NSSQLKAAVTPELCPDVTIWGVAMLRH 495
            .|:|:.|.:     ..:.|.|..|...:|.:   |:. ....|:|....|:|      |:
  Fly   185 MESHTEERR-----QNAVLWRHYEEKVVQRL---RVTWQLEDLEAEQVHEVC------GI----- 230

Human   496 MLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTS-----VSFISTVA 555
             |.:.|     ..|...|.|            |..::|...||.|.|:|||:     .||   ..
  Fly   231 -LDVNC-----FEIGQNGAK------------ARTLYPSAFLLAHDCTPNTAHTDDPSSF---EI 274

Human   556 TIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWEAFCC 620
            .:|.|:|:|:.:.:...|.  .:..|..:|:..:.....|.|                     ||
  Fly   275 LLRTSRRVREREALTLSYA--YTLQGTLKRRAFMHEGKLFWC---------------------CC 316

Human   621 NSCGAPMQ-GDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQ-----VRVAQKLLRDG--ELERAV 677
            ..|..|.: |.|   |.:..|   |..|...|..:..|||.     .|.|.|:   |  |:||.:
  Fly   317 RRCSDPRELGTD---CSALVC---ATCRTGSVRAVDPLQQTGDWACDRCAHKM---GATEVERQL 372

Human   678 QRLSGCQRD--------AESFLWAEHAVVGE----IADGLARACAALG-------------DWQK 717
            .|::....|        .|:||.....|:..    :.......|...|             |..:
  Fly   373 DRINNDLEDIDVHDIPGLENFLLRYRDVLRPNHYLLLSAKYSLCQIYGRTEGYLLPQMSPEDIAR 437

Human   718 SATHLQRSLYVVEV---------------RHGPSSVEMGHELFKLAQIFFNGF--AVPEALSTIQ 765
            ..::.:..|.:|:|               .|.|..| :....|:..||....|  .:.|.:..:|
  Fly   438 KESYCREFLEIVDVLDPGLTRLRGLIMYELHAPVMV-LAQSAFQSGQISRQEFQRRLKEVVKLLQ 501

Human   766 KAEEVL 771
            .:.::|
  Fly   502 VSRDIL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SMYD4	NP_443160.2	NlpI	<66..>171	CDD:443815
		TPR repeat	68..96	CDD:276809
		TPR repeat	101..135	CDD:276809
		TPR repeat	143..171	CDD:276809
		SET	239..>269	CDD:394802	9/29 (31%)
		zf-MYND	296..335	CDD:460312	12/47 (26%)
		SET_SMYD4	404..602	CDD:380934	40/203 (20%)
		TPR_12	660..726	CDD:315987	16/97 (16%)
		TPR_12	698..771	CDD:315987	15/106 (14%)
SmydA-4	NP_572675.1	SET_SMYD	<230..319	CDD:380997	27/137 (20%)