DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RHPN1 and BRO1

DIOPT Version :9

Sequence 1:	XP_011515119.1	Gene:	RHPN1 / 114822	HGNCID:	19973	Length:	729	Species:	Homo sapiens
Sequence 2:	NP_015241.1	Gene:	BRO1 / 856021	SGDID:	S000006005	Length:	844	Species:	Saccharomyces cerevisiae

Alignment Length:	375	Identity:	94/375 - (25%)
Similarity:	154/375 - (41%)	Gaps:	50/375 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   162 MIPLGLKETKELDWSTPLKELISVHFGED--GASY-EAEIRELEALRQ----AMRTPSRNESGLE 219
            :..|.||:|::|||...|...:...:|..  ...| |....||:.||.    .:...|.:|..|:
Yeast     5 LFDLKLKDTEKLDWKKGLSSYLKKSYGSSQWRTFYDEKATSELDHLRNNANGELAPSSLSEQNLK 69

Human   220 LLTAYYNQLCFLDARFLTPARSLGLFFHCLTQHCRYDSL-TGVPAQQRALAFEKGSVLFNIGALH 283
                ||:.|..|..|..:....|.:.|  ......|.|. .|:...|..|||||...||||..:.
Yeast    70 ----YYSFLEHLYFRLGSKGSRLKMDF--TWYDAEYSSAQKGLKYTQHTLAFEKSCTLFNIAVIF 128

Human   284 TQIGARQDRSCTEGARRAMEAFQRAAGAFSLLRENFSHAPSPDMSAASLCALEQLMMAQAQEC-V 347
            ||| ||:  :..|..:.::....:|...|..|.|||.::||.|:.:.:...|..:..|:|||. |
Yeast   129 TQI-ARE--NINEDYKNSIANLTKAFSCFEYLSENFLNSPSVDLQSENTRFLANICHAEAQELFV 190

Human   348 FEGLSPPASMAPQDCLAQLRLAQEAAQVAAEYRLVHRTMAQPPVHDYVPV----SWTALVHVKAE 408
            .:.|:...|......:::|..|     ....::..|..|.:  :.|.|.:    .|...|..|..
Yeast   191 LKLLNDQISSKQYTLISKLSRA-----TCNLFQKCHDFMKE--IDDDVAIYGEPKWKTTVTCKLH 248

Human   409 YFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQPPTSSKPRGPVLPQ--------ELEERRQLG 465
            :::||:.|:..:.|.:.:..  ||........:|...||.|....|.:        |..|::|
Yeast   249 FYKSLSAYYHGLHLEEENRV--GEAIAFLDFSMQQLISSLPFKTWLVEFIDFDGFKETLEKKQ-- 309

Human   466 KAHLKRAILGQEEALRLHALCRVLREVDLLR---AVISQTLQRSLAKYAE 512
                |..|  ::.....|.....:.:||.::   |:.|.|.::.|..|.:
Yeast   310 ----KELI--KDNDFIYHESVPAVVQVDSIKALDAIKSPTWEKILEPYMQ 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RHPN1	XP_011515119.1	HR1	74..158	CDD:294066
		BRO1_Rhophilin_1	162..552	CDD:185771	94/375 (25%)
		PDZ	573..639	CDD:214570
BRO1	NP_015241.1	BRO1_ScBro1_like	5..347	CDD:185765	92/367 (25%)
BRO1	NP_015241.1	V_ScBro1_like	368..702	CDD:185750
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770