Protein Alignment RHPN1 and Rhp

DIOPT Version :9

• Sequence 1: XP_011515119.1
• Gene: RHPN1 / 114822
• HGNCID: 19973
• Length: 729
• Species: Homo sapiens
• Sequence 2: NP_511168.3
• Gene: Rhp / 32531
• FlyBaseID: FBgn0026374
• Length: 718
• Species: Drosophila melanogaster
• Alignment Length: 723
• Identity: 250/723 - (34%)
• Similarity: 372/723 - (51%)
• Gaps: 116/723 - (16%)

Human    54 RGEDPVRVHVGPMNPQLHAVGCDSLTQIQCGQLQSRRAQIHQQIDKELQMRTGAENLYRATSNNR 118
            ||.||            .|..|.|       :||:||.:::::|:|||::|.||||||:||||.:
  Fly    33 RGSDP------------RAATCRS-------KLQNRRCKLNKEINKELRLRAGAENLYKATSNRK 78

Human   119 VRETVALELSYVNSNLQLLKEELEELSGGVDPGRHGSEAVTVPMIPLGLKETKELDWSTPLKELI 183
            :|:|||||||:||||||||||:|.||:..|:..:..|....:||||||||||||:::..|..:.|
  Fly    79 LRDTVALELSFVNSNLQLLKEQLAELNSSVEIYQSESHNGIMPMIPLGLKETKEINFMEPFSDFI 143

Human   184 SVHFGEDGASYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHC 248
            ..|:.|:.:.|...|.::...|||.:||||:..|:.||..|||.|.:::.||..|.|:||::|..
  Fly   144 LEHYSEEPSMYIDAIADMTDTRQASKTPSRDALGVALLFRYYNTLYYVERRFFPPDRNLGVYFEW 208

Human   249 LTQHCRYDSLTGVPAQQRALAFEKGSVLFNIGALHTQIGARQDRSCTEGARRAMEAFQRAAGAFS 313
                  ||||||||:.||.:||||...|||:|.::||||||.||:...|...|:::|.||||.|.
  Fly   209 ------YDSLTGVPSCQRTIAFEKACTLFNLGGIYTQIGARHDRTTERGLDLAVDSFLRAAGVFR 267

Human   314 LLRENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQDCLAQLRLAQEAAQVAAE 378
            .:.:.|::|||.|:....|..|..||::||:||:||.|.........||.|...||.||||::.|
  Fly   268 HIYDTFTNAPSMDLKPQVLDVLVSLMLSQARECLFEKLQLQIEAMSHDCQAFRDLAGEAAQISHE 332

Human   379 YRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQP 443
            |..:|:.:.....|.|:|..|..||.||||.:::.||::.|.::    .||: ||...:
  Fly   333 YNEMHKNIQANDTHTYLPECWAGLVPVKAELYKAFAHFYKARSI----DATD-ELKASK------ 386

Human   444 PTSSKPRGPVLPQELEERR----QLGK------------AHLKRAILGQEEALRLHALCRVLRE- 491
             :|.|.:...:....|..|    ..|.            ||||.|:...|||.||..:||.|:.
  Fly   387 -SSQKNQESFIGNSQEVERITTADYGASDEASTSIANKLAHLKEALASIEEAQRLQRMCRFLKNK 450

Human   492 ---VDLLRAVISQTLQRSLAKY-----AELDREDDFCEAAEAPDIQPKTHQKPEARMPRLSQGKG 548
               .::::.|.|:: |..|.|:     |:...:.|..|.:    ::..:........|..:..|.
  Fly   451 ASLTEVMKEVHSKS-QEELEKFRLQASAKNIEDGDLLERS----VEASSKFTLSLTGPDFTSHKV 510

Human   549 PDIFHRLGPLSVFSAKNRWRLVGPVHLTRG------------------------EGG-------- 581
            .|.|.||||:::|||:..|.....|.|.:|                        :||
  Fly   511 KDPFKRLGPIAIFSARRHWTAPRCVRLQKGSSLYHSVPSNDNKCPLDNDDDEEHDGGYNLYKEEF 575

Human   582 --FGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNGQPCRWWRHAEVVTELKAAGEAGASL 644
              ||..:|||:||:||.|...|.|...|:||||:||.:.|...:|:.|.:||..:::.|.. ..|
  Fly   576 ENFGFHVRGDAPVIIAHVEINSLADLGGIKEGDFIVEIAGVDVKWYSHQQVVQLIQSCGST-LEL 639

Human   645 QVVSLLPSSRLPSLGDRRPVLLGPRGLLRSQREHGCKT--PASTWASPRPLLNWSRKAQQGKTGG 707
            :|::.:..:.|..|..:     |....|.:....|..:  |:.|..:.:|.|:.       ||..
  Fly   640 RVITPMDRNYLKPLSSK-----GSLSTLSAASSSGISSGFPSPTSIAAKPKLHL-------KTSS 692

Human   708 CPQPCAPV 715
            ..:|...|
  Fly   693 SSRPAGSV 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHPN1	XP_011515119.1	HR1	74..158	CDD:294066	44/83 (53%)
		BRO1_Rhophilin_1	162..552	CDD:185771	146/414 (35%)
		PDZ	573..639	CDD:214570	29/99 (29%)
Rhp	NP_511168.3	HR1_Rhophilin-1	34..118	CDD:212023	48/102 (47%)
		BRO1_Rhophilin	122..514	CDD:185767	146/414 (35%)
		PDZ_signaling	570..642	CDD:238492	26/72 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144349
Domainoid	1	1.000	284	1.000	Domainoid score	I1633
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1853
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49710
OrthoDB	1	1.010	-	-		D286986at33208
OrthoFinder	1	1.000	-	-		FOG0003216
OrthoInspector	1	1.000	-	-		otm42233
orthoMCL	1	0.900	-	-		OOG6_105514
Panther	1	1.100	-	-	LDO	PTHR23031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5869
SonicParanoid	1	1.000	-	-		X1868
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800