DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RHPN1 and SPAC2G11.05c

DIOPT Version :9

Sequence 1:	XP_011515119.1	Gene:	RHPN1 / 114822	HGNCID:	19973	Length:	729	Species:	Homo sapiens
Sequence 2:	NP_593085.1	Gene:	SPAC2G11.05c / 2541947	PomBaseID:	SPAC2G11.05c	Length:	701	Species:	Schizosaccharomyces pombe

Alignment Length:	377	Identity:	70/377 - (18%)
Similarity:	140/377 - (37%)	Gaps:	94/377 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   193 SYEAEIRELEALRQAMRTPSRNESGLELLTAYYNQLCFLDARFLTPARSLGLFFHCLTQHC-RYD 256
            :||.:::..:|||..:.....:.:.|.....|:..||.|:.:.|:         .|:.... ...
pombe    33 TYENDLKTFKALRSQLCLSHPSINSLSSFQTYHQLLCVLEQKHLS---------ECVAPFVWTLS 88

Human   257 SLTGVPAQQRALAFEKGSVLFNIGALH--TQIGARQDRSCTEGARRAMEA---FQRAAGAFSLLR 316
            |.:........|.||...:::.:...:  |.|..     |.|.....::|   ||.:||.|..:.
pombe    89 SSSNERESFENLIFEHACLIYRLACTYHTTAISL-----CNEKPPNLVQACQYFQLSAGCFRYIN 148

Human   317 ENFSHAPSPDMSAASLCALEQLMMAQAQECVFEGLSPPASMAPQ---DCLAQLRLAQEAAQVAAE 378
            :.:.:..|.|.:...|.|.|...:|:||.|:|...:...:.:..   ..||::.|..|.|
pombe   149 DFYIYTKSLDFNENLLKAWEIYCLAEAQTCIFSKANSNDTTSESIIVKILAKVFLLYEDA----- 208

Human   379 YRLVHRTMAQPPVHDYVPVSWTALVHVKAEYFRSLAHYHVAMALCDGSPATEGELPTHEQVFLQP 443
            |:|.......|.:.    |.||   :::..:::::.:                      |:..:.
pombe   209 YKLFKNATGAPSIF----VHWT---YIQKLFYQTITY----------------------QIISRT 244

Human   444 PTSSKPRGPVLPQELEERRQLGKAHLKRAILGQEEALRLH----ALCRVLREVDLLRAVISQTLQ 504
            ..|....|..:            ::|:.::|..:|||:..    ...:|..:::.|.:.:...|:
pombe   245 SYSLNKYGENI------------SYLRLSLLHCKEALKTRFDFGFNVKVYEKLEKLESSLQFELK 297

Human   505 RSLAKYAELDREDDFCEAAEAPDIQPKTHQKPEARMPRLS-----QGKGPDI 551
            |:       :|::||..      :||:.   |....|.|.     |...||:
pombe   298 RN-------ERDNDFIH------LQPEI---PVGSFPLLDTVTMVQSITPDV 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RHPN1	XP_011515119.1	HR1	74..158	CDD:294066
		BRO1_Rhophilin_1	162..552	CDD:185771	70/377 (19%)
		PDZ	573..639	CDD:214570
SPAC2G11.05c	NP_593085.1	BRO1_ScRim20-like	2..354	CDD:185764	70/377 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2220
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810