DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKD1L2 and Pkd1l2

DIOPT Version :9

Sequence 1:	NP_443124.3	Gene:	PKD1L2 / 114780	HGNCID:	21715	Length:	2459	Species:	Homo sapiens
Sequence 2:	XP_036010263.1	Gene:	Pkd1l2 / 76645	MGIID:	2664668	Length:	2466	Species:	Mus musculus

Alignment Length:	2469	Identity:	1822/2469 - (73%)
Similarity:	2044/2469 - (82%)	Gaps:	15/2469 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSAVGLVLLVLALRLRATTVKPEEGSFCSNSQVAFRDACYEFVPLGRTFRDAQSWCEGQGGHLVF 65
            |:..|||.|.|||...||..|.|.||.||.|||.|||||||||||..||..||.||||.||||.|
Mouse     1 MTMAGLVFLGLALSSGATVAKSEGGSLCSRSQVFFRDACYEFVPLEHTFPGAQGWCEGHGGHLAF 65

Human    66 IQDEGTQWFLQKHISQDREWWIGLTWNLARNGTTEGPGTWLDTSNVTYSNWHGGQAAAAPDTCGH 130
            |.||.||.|||:||:||||||||||.....|||..|.|||||||||.||||..|||..||.:||:
Mouse    66 IPDEDTQQFLQRHITQDREWWIGLTGGSGHNGTVGGSGTWLDTSNVNYSNWQEGQATPAPGSCGY 130

Human   131 IGRGPSSEWVT-SDCAQTFAFMCEFRVGQSLACEGLNATVHCGLGQVIQVQDAVYGRQNPHFCTQ 194
            ||.||||:|.. .||.|||||:|||.||:||||||.|||:||..|:||.||||.||.|.|:.||:
Mouse   131 IGSGPSSQWAALEDCTQTFAFVCEFGVGRSLACEGHNATMHCDSGEVILVQDAFYGHQTPYLCTR 195

Human   195 DAGRPSDLEQGCSWANVKEEVAGQCQELQSCQVAADETYFGNLCPTQGSYLWVQYQCREALQLMV 259
            ....|||||..|.|.:||:|||||||.||:||||.|.||||:.|||:||||||||||.|.|:|:|
Mouse   196 GIWPPSDLEGECGWVSVKDEVAGQCQGLQACQVAVDGTYFGDPCPTRGSYLWVQYQCLEGLRLVV 260

Human   260 SSESFIFDNVTISLTWLLSPYIGNLSCIISTGDSHTFDPYNPPSVSSNVTHQFTSPGEFTVFAEC 324
            .:.|||||||||||.||||||.|||||::|.||.:||||||||||||||||||:|||||||||||
Mouse   261 PNGSFIFDNVTISLMWLLSPYTGNLSCVLSMGDGYTFDPYNPPSVSSNVTHQFSSPGEFTVFAEC 325

Human   325 TTSEWHVTAQRQVTVRDKMETLSVTACSGLSQSGAGPLCQAVFGDPLWIQVELDGGTGVTYTVLL 389
            ||||||||||:||.:.:|:||..:|.|:||:.:|.|.|||||||:|||:||:||||.|.||.||.
Mouse   326 TTSEWHVTAQKQVILCEKVETPRITGCTGLAGAGVGLLCQAVFGEPLWVQVDLDGGAGATYAVLS 390

Human   390 GDITLAESTTQKGSLPYNLILDRETQKLMGPGRHRLEIQATGNTTTSTISR---NITVHLVELLS 451
            .:.||||.|.|:||..|||.|||:.|:::|||||.|:|||..|..|.|.|.   |.||:.||.||
Mouse   391 HNRTLAEFTAQRGSQLYNLTLDRDIQEMLGPGRHHLKIQAVSNEGTGTASAPSGNFTVYFVEPLS 455

Human   452 GLQASWASDHLELGQDLLITISLAQGTPEELTFEVAGLNATFSHEQVSFGEPFGICRLAVPVEGT 516
            ||:||||||.:|||.||::.:|:|:||.||||||||||||.||.|:.|.|:..|...:|||.|||
Mouse   456 GLRASWASDRVELGWDLVVNVSVARGTLEELTFEVAGLNANFSQEEESVGQSSGNYHVAVPAEGT 520

Human   517 FLVTMLVRNAFSNLSLEIGNITITAPSGLQEPSGMNAEGKSKDKGDMEVYIQPGPYVDPFTTVTL 581
            ||||:.||||||.|||:|||||:||.|.|||.||:|||.||..|.||:|:.:|..||||||.|||
Mouse   521 FLVTVHVRNAFSELSLDIGNITVTASSSLQELSGINAEAKSGHKQDMKVFTEPELYVDPFTEVTL 585

Human   582 GWPDNDKELRFQWSCGSCWALWSSCVERQLLRTDQRELVVPASCLPPPDSAVTLRLAVLRGQELE 646
            ||||:|..|.|.||||.|||.|::||.||||.||||.||:...||||.:|||||.||:|||||||
Mouse   586 GWPDDDPGLNFHWSCGRCWAQWNACVGRQLLHTDQRLLVLHTFCLPPLNSAVTLHLAILRGQELE 650

Human   647 NRAEQCLYVSAPWELRPRVSCERNCRPVNASKDILLRVTMGEDSPVAMFSWYLDNTPTEQAEPLL 711
            ...|||||||||..|.|::|||:|||||.|.:|:||.||:|:::.||:||||||:|..|:||||.
Mouse   651 KETEQCLYVSAPLNLGPQISCEKNCRPVKADQDVLLTVTVGDETSVAVFSWYLDDTVPEEAEPLP 715

Human   712 DACRLRGFWPRSLTLLQSNTSTLLLNSSFLQSRGEVIRIRATALTRHAYGEDTYVISTVPPREVP 776
            .|||||||||||||||.||:|.|||||||||:.|.||.||.||||.||||||||:||.:|..|||
Mouse   716 AACRLRGFWPRSLTLLHSNSSVLLLNSSFLQTWGPVIPIRVTALTSHAYGEDTYMISMLPRPEVP 780

Human   777 ACTIAPEEGTVLTSFAIFCNASTALGPLEFCFCLESGSCLHCGPEPALPSVYLPLGEENNDFVLT 841
            ||||.||||:|||||.:.|:....|||:|:||||.||.|||||||||||:||||||||.:.|||.
Mouse   781 ACTIDPEEGSVLTSFTVSCSTPATLGPVEYCFCLPSGFCLHCGPEPALPAVYLPLGEEKDGFVLP 845

Human   842 VVISATNRAGDTQQTQAMAKVALGDTCVEDVAFQAAVSEKIPTALQGEGGPEQLLQLAKAVSSML 906
            ||||.||||||.:|||...||....|.||||.||..|||:|.|||..|.|.||||..||||||.|
Mouse   846 VVISVTNRAGDIEQTQVAVKVGHSYTGVEDVTFQEMVSERIATALHQESGREQLLLFAKAVSSEL 910

Human   907 NQEHESQGSGQSLSIDVRQKVREHVLGSLSAVTTGLEDVQRVQELAEVLREVTCRSKELTPSAQW 971
            |.|.:|.|||| |.:|:::||||.:|.|||.|||||:::||||.|||||||||.|::||||:|||
Mouse   911 NSEVQSPGSGQ-LGMDIKRKVRELMLRSLSVVTTGLQNMQRVQALAEVLREVTQRAEELTPAAQW 974

Human   972 EASLALQHASEALLTVSAKARPEDQRRQAATRDLFQAVGSVLEASLSNRPEEPAEASSSQIATVL 1036
            |||.|||.|:||||..|.|.||||||||.|||.:|:|||||||||||:|.|||.||:|||...|.
Mouse   975 EASCALQRATEALLVASTKVRPEDQRRQEATRAMFEAVGSVLEASLSHRSEEPMEANSSQAYIVA 1039

Human  1037 RLLRVMEHVQTTLLLGKLPGGLPAMLATPSISVYTNRIQPWSWQGSSLRPDAADSATFMLPAASS 1101
            :||||::|.|:.||||.|||||||:|.||||||||:||||.||||||:...||||.||.||||:.
Mouse  1040 QLLRVIDHFQSALLLGTLPGGLPAILVTPSISVYTDRIQPRSWQGSSVHTAAADSVTFTLPAATF 1104

Human  1102 LSSLEGGQEPVDIKIMSFPKSPFPARSHFDVSGTVGGLRVTSPSGQLIPVKNLSENIEILLPRHS 1166
            |..:|..||||||::|||.::|||:||.|||||||||||:||.||..|||||||:||||||||.|
Mouse  1105 LCPMEDSQEPVDIRMMSFSQNPFPSRSQFDVSGTVGGLRLTSSSGHPIPVKNLSQNIEILLPRIS 1169

Human  1167 QRHSQPTVLNLTSPEALWVNVTSGEATLGIQLHWRPDIALTLSLGYGYHPNKSSYDAQTHLVPMV 1231
             .|.:|.:|:|.|.|||.||||:|:..|||||||.|.:.|.||||||||||::||||||||.|:.
Mouse  1170 -AHIEPKMLSLASREALSVNVTAGDTALGIQLHWGPGVPLILSLGYGYHPNETSYDAQTHLPPVA 1233

Human  1232 APDELPTWILSPQDLRFGEGVYYLTVVPESDLEPAPGRDLTVGITTFLSHCVFWDEVQETWDDSG 1296
            |..:||||||.|:||.||||||||.||||:|||.:.||:|||||||||:|||||||.||||||||
Mouse  1234 ATGDLPTWILHPEDLPFGEGVYYLRVVPEADLESSSGRNLTVGITTFLAHCVFWDETQETWDDSG 1298

Human  1297 CQVGPRTSPYQTHCLCNHLTFFGSTFLVMSNAINIHQTAELFATFEDNPVVVTTVGCLCVVYVLV 1361
            |||||||:|.||||||||||||||:||||.|||::.|||||||||||||||||||||||::||||
Mouse  1299 CQVGPRTTPSQTHCLCNHLTFFGSSFLVMPNAIDVRQTAELFATFEDNPVVVTTVGCLCMLYVLV 1363

Human  1362 VIWARRKDAQDQAKVKVTVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGEREPHHL 1426
            :|||||||.||||||||.||||||||||||||||||||||||||||||||:||||.|||.|||||
Mouse  1364 LIWARRKDIQDQAKVKVVVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTLTLYGSDGESEPHHL 1428

Human  1427 ADPDTPVFERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVMDRKWYFLCNS 1491
            :|||..|||||.||.||||||||||||:||||||||||||||||||||||||.|:||||||||||
Mouse  1429 SDPDAAVFERGGVDVFLLSTLFPLGELQSLRLWHDNSGDRPSWYVSRVLVYDSVVDRKWYFLCNS 1493

Human  1492 WLSINVGDCVLDKVFPVATEQDRKQFSHLFFMKTSAGFQDGHIWYSIFSRCARSSFTRVQRVSCC 1556
            |||::||||||||||||||||||||||||||.|||.||||||||||:|....|||||||||||||
Mouse  1494 WLSVDVGDCVLDKVFPVATEQDRKQFSHLFFTKTSTGFQDGHIWYSVFCSATRSSFTRVQRVSCC 1558

Human  1557 FSLLLCTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFQNTRPR 1621
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||
Mouse  1559 FSMLLCTMLTSIMFWGVPKDPAEQKMDLGKIEFTWQEVMIGLESSILMFPINLLIVQIFRNTRPR 1623

Human  1622 VAKEQNTGKWDRGSPNLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPALGWDSVNLMD 1686
            :...:: |:..:|.||||||.||.|:||||||.|||.:..::|||||||||..||.||||:|.:|
Mouse  1624 LPMGKD-GRQKQGPPNLTPSAQPTEEGLLTPETVTKGIQSLISSLFKALKVQPPASGWDSMNPVD 1687

Human  1687 INSLLALVEDVIYPQNTSGQVFWEEAKKREDPVTLTLGSSEMKEKSQCPKPKAARSGPWKDSAYR 1751
            ||.||.|:||:|.|::|.|..||||||.||||:|.|.||.:.||.:..|||:.|..|.||||.||
Mouse  1688 INYLLTLMEDIICPESTEGPGFWEEAKGREDPITSTRGSVKPKENTWHPKPELAVRGLWKDSVYR 1752

Human  1752 QCLYLQLEHVEQELRLVGPRGFSQPHSHAQALRQLQTLKGGLGVQPGTWAPAHASALQVSKPPQG 1816
            :||||||||||:||:|:||:||...||||||||||..|||.|..||||.|.|:.|..:|||.|:|
Mouse  1753 RCLYLQLEHVERELQLLGPQGFLHHHSHAQALRQLHVLKGHLWGQPGTPALAYPSTSRVSKSPRG 1817

Human  1817 LPWWCILVGWLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAVSFVESMFVTQPLKVLGFAAF 1881
            |||||:||||||||.||||||||||||||||||.|||:||||||||||||:|:||||||||||||
Mouse  1818 LPWWCVLVGWLLVATTSGVAAFFTMLYGLHYGRVSSLKWLISMAVSFVESVFITQPLKVLGFAAF 1882

Human  1882 FALVLKRVDDEEDTVAPLPGHLLGPDPYALFRARRNSSRDVYQPPLTAAIEKMKTTHLKEQKAFA 1946
            |||||||.|||| |:...||||..|.|..|||:||:||...||||..|||||||||.||||||||
Mouse  1883 FALVLKREDDEE-TLPLFPGHLSSPGPGVLFRSRRHSSERAYQPPPMAAIEKMKTTRLKEQKAFA 1946

Human  1947 LIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQHSFTRGFSGVLGFREFFKWANTTLVSNLYG 2011
            |||||||||.|||||||||||||||:|||.:|||:.||::|||.|||||.||:|||||||.||||
Mouse  1947 LIREILAYLAFLWMLLLVAYGQRDPNAYHFHRHLERSFSQGFSPVLGFRGFFEWANTTLVKNLYG 2011

Human  2012 HPPGFITDGNSKLVGSAQIRQVRVQESSCPLAQQPQAYLNGCRAPYSLDAEDMADYGEGWNATTL 2076
            |.|||:|||||||||||.||||||:||||.:|||.|..|:||..||||..||:.||||||||:..
Mouse  2012 HHPGFVTDGNSKLVGSAHIRQVRVRESSCAVAQQLQDSLDGCHGPYSLGIEDLVDYGEGWNASAY 2076

Human  2077 SE-------WQYQSQDQRQGYPIWGKLTVYRGGGYVVPLGTDRQSTSRILRYLFDNTWLDALTRA 2134
            :.       |:||||.||:|||:|||||:|.|||||||||||.||.||||:|||||:||||||||
Mouse  2077 NNSNGFPQAWRYQSQSQRRGYPMWGKLTLYGGGGYVVPLGTDHQSASRILQYLFDNSWLDALTRA 2141

Human  2135 VFVESTVYNANVNLFCIVTLTLETSALGTFFTHAALQSLRLYPFTDGWHPFVVAAELIYFLFLLY 2199
            ||||.|||||||||||.||||||||.|||||:|..||||||||||||||||||||||.|||||.|
Mouse  2142 VFVEFTVYNANVNLFCTVTLTLETSGLGTFFSHVTLQSLRLYPFTDGWHPFVVAAELTYFLFLFY 2206

Human  2200 YMVVQGKRMSKETWGYFCSKWNLLELAIILASWSALAVFVKRAVLAERDLQRCRNHREEGISFSE 2264
            |||||||.|.|:.||||||||||||:||||||||||.|||||.:||:|||||.|.||:|||||||
Mouse  2207 YMVVQGKLMRKQKWGYFCSKWNLLEVAIILASWSALVVFVKRTILADRDLQRYREHRDEGISFSE 2271

Human  2265 TAAADAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIAS 2329
            |||||||||||||||||||||||||||||||||||||:||||||||||||:.|||.||||||.||
Mouse  2272 TAAADAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITSALRRAWGDISGFVAVILIMLLAYSFAS 2336

Human  2330 NLIFGWKLRSYKTLFDAAETMVSLQLGIFNYEEVLDYSPVLGSFLIGSCIVFMTFVVLNLFISVI 2394
            ||:||||||||||||||||||||||||||||||||||||:|||.|||||||||||||||||||||
Mouse  2337 NLVFGWKLRSYKTLFDAAETMVSLQLGIFNYEEVLDYSPILGSLLIGSCIVFMTFVVLNLFISVI 2401

Human  2395 LVAFSEEQKYYQLSEEGEIVDLLLMKILSFLGIKSKREEPGSSREQPGSLSQTRHSRPAQALPK 2458
            |||||||||..||.|||||.||||:||||||||:.||||..||.|||....|....:|||||.:
Mouse  2402 LVAFSEEQKSDQLWEEGEIADLLLVKILSFLGIRCKREETWSSSEQPELPPQALAPQPAQALSR 2465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKD1L2	NP_443124.3	CLECT	28..153	CDD:214480	87/125 (70%)
		Gal_Lectin	170..251	CDD:307994	53/80 (66%)
		GPS	1280..1319	CDD:197639	34/38 (89%)
		PLAT_polycystin	1390..1509	CDD:238850	105/118 (89%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1625..1649		11/23 (48%)
		PKD_channel	1987..2400	CDD:332708	349/419 (83%)
		Channel pore-region	2340..2362		21/21 (100%)
		Interaction with GNAS and GNAI1. /evidence=ECO:0000269\|PubMed:15203210	2379..2459		59/80 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2431..2459		14/28 (50%)
Pkd1l2	XP_036010263.1	CLECT	28..154	CDD:214480	87/125 (70%)
		Gal_Lectin	170..252	CDD:396628	53/81 (65%)
		REJ	493..866	CDD:366875	254/372 (68%)
		GPS	1282..1321	CDD:396408	34/38 (89%)
		PLAT_polycystin	1392..1511	CDD:238850	105/118 (89%)
		PKD_channel	1987..2407	CDD:400395	349/419 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83967450
Domainoid	1	1.000	733	1.000	Domainoid score	I3438
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H124481
Inparanoid	1	1.050	3633	1.000	Inparanoid score	I358
Isobase	1	0.950	-	0	Normalized mean entropy	S8204
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50348
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	1	1.000	-	-		FOG0009690
OrthoInspector	1	1.000	-	-		oto128161
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5261
SonicParanoid	1	1.000	-	-		X10367
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	16.490