DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Acvr1 and tkv

DIOPT Version :9

Sequence 1:	NP_001103674.1	Gene:	Acvr1 / 11477	MGIID:	87911	Length:	509	Species:	Mus musculus
Sequence 2:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	236/520 - (45%)
Similarity:	326/520 - (62%)	Gaps:	53/520 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    22 EDEKPKV--NQKLYMCVCEGLSCG---NEDHCE---GQQCFSSLS--INDGFHVYQK----GCFQ 72
            ::||.|.  |.:...|.|:| ||.   :...||   |..|||::.  .::...:|::    ||..
  Fly    68 DNEKSKTVENARSLTCYCDG-SCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMP 131

Mouse    73 VYEQGK-MTCKTPPSP---GQAVECC-QGDWCNRNI----TAQLPTKGKSFP-GTQNFH-LEV-G 125
            ..:.|. :.||....|   |:.:.|| :.|:|||::    |.:|.|.....| .:::.| |.| |
  Fly   132 PEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLAVFG 196

Mouse   126 LIILSVVFAVCLLACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTS 190
            .||:|:...:.::|.:.....|:.|.|.|.||         |..:..:.:  |.|::|::.|  |
  Fly   197 SIIISLSVFMLIVASLCFTYKRREKLRKQPRL---------INSMCNSQL--SPLSQLVEQS--S 248

Mouse   191 GSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTV 255
            |||||||.|||||:|:||.::..||||||||||...|:.|.||||.|.:.:|.|||||||:|.||
  Fly   249 GSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTV 313

Mouse   256 MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLH 320
            ::||:|||||||:|:....|.||:.|||.|||||||:|||.::.::......:..|:||||||||
  Fly   314 LMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLH 378

Mouse   321 IEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE 385
            .|||||.||.||||||:||||||||:||||.|||.||||.::...:.:.:..||||||:||||||
  Fly   379 DEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPE 443

Mouse   386 VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRM------VSNGIVEDYKPPFYDVVPNDPSFEDM 444
            ||.:.:....|:.:||.|:::.||||||:.||.      ......|||..|::||||:||:||||
  Fly   444 VLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDM 508

Mouse   445 RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509
            ..||||...||.||:||..|..|.:::|:|:|||:.||:.||||||:|||       |.:|:|||
  Fly   509 HAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKT-------LGRLETDC 566

Mouse 510 509
Fly 567 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Acvr1	NP_001103674.1	Activin_recp	33..103	CDD:366445	25/86 (29%)
		TGF_beta_GS	179..206	CDD:369918	16/26 (62%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	168/302 (56%)
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	25/90 (28%)
		GS	238..266	CDD:197743	18/29 (62%)
		S_TKc	267..557	CDD:214567	160/289 (55%)
		STKc_BMPR1	270..562	CDD:271046	164/298 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834713
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740