DRSC/TRiP Functional Genomics Resources

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Protein Alignment Actn3 and Dys

DIOPT Version :9

Sequence 1:NP_038484.1 Gene:Actn3 / 11474 MGIID:99678 Length:900 Species:Mus musculus
Sequence 2:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster


Alignment Length:1122 Identity:248/1122 - (22%)
Similarity:412/1122 - (36%) Gaps:368/1122 - (32%)


- Green bases have known domain annotations that are detailed below.


Mouse    36 LLLDPAWEKQ--QRKTFTAWCNSHLRKAG-TQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGK 97
            :|:|   |:|  |:||||.|.||||.... |.::::..|.|:|.:|:.||..::...| :|:||:
  Fly     5 ILID---ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGR 65

Mouse    98 MRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDI--SVEETSAK 160
            ||.|.|.|:||.:..|...|||||:|.:::||.||.|:|||:||.|.|.|..|.:  |......:
  Fly    66 MRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVE 130

Mouse   161 EGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVA 225
            :.||.|.::.|.|: .:.:.:|.:||.||.|...::..|..:|...|.|:: ..:..|:.||::|
  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQ-HALKRLHLAFDLA 193

Mouse   226 EKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAG-------AEQAE-------------- 269
            .::..|.|:||||| |:|.|||.|:|..||.|.|||...       .||.|              
  Fly   194 HRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSI 257

Mouse   270 -------------------------------------------TAANRICK----------VLAV 281
                                                       ||.|...:          ||.:
  Fly   258 TDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVLTL 322

Mouse   282 NQENEKLM--------------------EEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKL 326
            ..|:|:|:                    |.:....:|..|::...:....|.:.|...:......
  Fly   323 LLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLSQ 387

Mouse   327 EDFRDYRRLHKPPRVQEKCQLEINFNTLQ-----------------TKLRLSHRPAFMPSEGKLV 374
            ||..:.|        |:...|...:.||:                 .|.:|.....|:.|....:
  Fly   388 EDQNEVR--------QQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRI 444

Mouse   375 SDIANAWRGLEQVEKGYEDWLLSEIRRLQ----RLQHLAEKF------------------QQKAS 417
            |.:::....||:.||     .|.|.::|:    ..|.|.:..                  .:.::
  Fly   445 SHMSDIGPTLEEAEK-----QLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLEDRLSA 504

Mouse   418 LHEAWTRGKEEMLNQHDYESASLQEVRALLRRHEAFESDLAAHQDR-VEHIAALAQELNELDY-- 479
            |.|.|:    .::...|.....||:.:.:.|..:|.|.||...:.| |..:..:.|.:|||:|  
  Fly   505 LGERWS----HVVKWSDLRKEKLQQYKCISRWLDAREQDLKLMESRDVTDVGGITQRINELNYCA 565

Mouse   480 -------HEAASVNSRCQAICDQWDNLGTLT----QKRRDALERMEKLLET----IDQLQLEFAR 529
                   .....:.....|.....|:.|...    :...|.|:.:::::|.    |:.....|.|
  Fly   566 KDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGR 630

Mouse   530 RAAPFNN--------WLD----------------------------------GAIED--LQDVWL 550
            ..|.:::        |:|                                  .|:|:  ::....
  Fly   631 DRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALENHIMEHFGY 695

Mouse   551 VHSVE------ETQSLLTAHEQFK----------ATLPE----------ADRERGAILGIQGEIQ 589
            |..||      :.|||....|..|          .||||          .|..|..:|. :..|:
  Fly   696 VQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLE-ETHIK 759

Mouse   590 KICQTYG-----LRPKSGNPYITLSSQDINNKWDTVRKLV--PSRD------------------- 628
            ::.|.|.     |..:....:..|:.:...|.. |..|||  .|||                   
  Fly   760 QLEQRYANLSQKLSSQQSESHTLLAKEKYYNSL-TGFKLVLADSRDWYKQHAGSASGNELEQRLS 823

Mouse   629 --QTLQEEL-----ARQQVNERL---RRQFAAQANAIGPW------IQGKVEEVGRLAAGLAGSL 677
              ::|..|:     |.:::::.|   ::.|....::   |      :|..:::.|      ..||
  Fly   824 HMESLASEISEAKTATEELDDNLIEWKQDFGLFYDS---WHDMKQALQALIQQRG------GESL 879

Mouse   678 EEQMAGLRQQEQNIINYKSNIDRL----EGDH---QLLQE----SLVFDN--KHTVYSMEHIRVG 729
            ..|:..::.....:.|.|..:..|    |..|   |||.|    .|.:||  ||.:  .|.::..
  Fly   880 SRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLI--GEELQTA 942

Mouse   730 W----EQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHF--------DRKRNGMMEPD 782
            |    |||...:.:....:||              ||.|.|.:|..        |.|.||   .|
  Fly   943 WNRLPEQLNERVIKQTTAIEN--------------LNHFAAEYNAIIAMLRSAADSKLNG---SD 990

Mouse   783 DFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTAEQVVASFKILAGD 847
            .      :...||.::|       :|     |::.:.|.:.:.:| ||....|.:.:..:.|  :
  Fly   991 G------ASSQDLRKLE-------ID-----VISARNFSEILIKE-AEPAQKESLQSQIRAL--N 1034

Mouse   848 KNYITPEELRRELPAEQ 864
            ..|...|::.||...:|
  Fly  1035 TLYDQVEQVHREKKEQQ 1051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Actn3NP_038484.1 Actin-binding 1..260 90/228 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
SAC6 42..>305 CDD:227401 105/361 (29%)
Spectrin 1 287..397 22/146 (15%)
Spectrin 287..396 CDD:334073 22/145 (15%)
Spectrin 2 407..512 24/136 (18%)
SPEC 408..635 CDD:238103 62/360 (17%)
Spectrin 3 522..633 36/208 (17%)
SPEC 526..746 CDD:238103 65/348 (19%)
Spectrin 4 643..746 27/128 (21%)
PTZ00184 753..>857 CDD:185504 23/111 (21%)
EFhand_Ca_insen 830..896 CDD:312305 8/35 (23%)
DysNP_001036722.1 CH 13..111 CDD:278723 45/98 (46%)
CH 129..225 CDD:278723 35/98 (36%)
SPEC 312..525 CDD:238103 36/229 (16%)
SbcC <325..957 CDD:223496 119/661 (18%)
Smc <816..1591 CDD:224117 58/285 (20%)
SPEC 1174..1365 CDD:238103
SPEC 1289..1485 CDD:295325
SPEC 2369..2576 CDD:238103
SPEC 2477..2714 CDD:238103
WW 2852..2882 CDD:238122
EF-hand_2 2883..2997 CDD:286194
EF-hand_3 3001..3100 CDD:286195
ZZ_dystrophin 3110..3158 CDD:239074
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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