DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actl7a and Act88F

DIOPT Version :9

Sequence 1:	NP_033741.1	Gene:	Actl7a / 11470	MGIID:	1343051	Length:	440	Species:	Mus musculus
Sequence 2:	NP_524367.1	Gene:	Act88F / 41885	FlyBaseID:	FBgn0000047	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	370	Identity:	161/370 - (43%)
Similarity:	238/370 - (64%)	Gaps:	6/370 - (1%)

- Green bases have known domain annotations that are detailed below.

Mouse    76 AVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGHELFNPDIHLKLVNPL 140
            |:|:|.|:|.||.||||...|.....:.||:|..:....|..:|:::||.|..:....|.|..|:
  Fly     8 ALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPI 72

Mouse   141 RHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAY 205
            .||||.:||.::.||.:.|..|:::|||||.||:::.||:|..||||..:::|||||:|||::|.
  Fly    73 EHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNSPAMYVAI 137

Mouse   206 QSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMNLMNNSGKHFS 270
            |:.||:|:.|||:|:|::.|.|||:.||||||:.||....|||.||.|||.|||.::...|..|:
  Fly   138 QAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGFALPHAILRLDLAGRDLTDYLMKILTERGYSFT 202

Mouse   271 ED-HLGIVEDIKTRCCFVALDPIEEKKIPAPEHEIH--YTLPDGKEIRLGQERFLCSEMFFKPSL 332
            .. ...||.|||.:.|:||||..:|....|....:.  |.||||:.|.:|.|||.|.|..|:||.
  Fly   203 TTAEREIVRDIKEKLCYVALDFEQEMATAAASTSLEKSYELPDGQVITIGNERFRCPEALFQPSF 267

Mouse   333 IKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTPQVNVL 397
            :.....|:|....:.:.|||:.:::||..|.:|.||:||..|..:|:|||::::.|: |.::.::
  Fly   268 LGMESCGIHETVYNSIMKCDVDIRKDLYANSVLSGGTTMYPGIADRMQKEITALAPS-TIKIKII 331

Mouse   398 --PERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF 440
              |||..:||.||||||||..||.:|:.:.||:|.||..::|:||
  Fly   332 APPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actl7a	NP_033741.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		ACTL7A_N	6..70	CDD:293445
		Required for interaction with TES. /evidence=ECO:0000250	36..56
		NBD_sugar-kinase_HSP70_actin	72..440	CDD:302596	159/368 (43%)
		ACTIN	74..440	CDD:214592	159/368 (43%)
Act88F	NP_524367.1	PTZ00281	1..376	CDD:173506	159/368 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11937
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910