DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc5a5 and CG32669

DIOPT Version :9

Sequence 1:	NP_443215.2	Gene:	Slc5a5 / 114613	RGDID:	69267	Length:	618	Species:	Rattus norvegicus
Sequence 2:	NP_727460.1	Gene:	CG32669 / 326229	FlyBaseID:	FBgn0052669	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	607	Identity:	221/607 - (36%)
Similarity:	327/607 - (53%)	Gaps:	69/607 - (11%)

- Green bases have known domain annotations that are detailed below.

  Rat    10 ATFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVL 74
            ||.|||||.:.|.:|::|..||::.....|.|.:..::....|.:...||..||.|||||||.:|
  Fly     2 ATLGAWDYTILAVVLIISVAIGIYYRFVGGKQSTTTEYLLADRSMNVAPVAFSLMASFMSAVTIL 66

  Rat    75 GVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLV 139
            ||..|..:||..|:.:....:|::.:.|:|.:|:||||...|.|:||||||..|.||..:|.:.:
  Fly    67 GVSMENYQYGTMFVVINLSYVLSTPVAAYLIIPVFYRLKTASVYEYLELRFGYATRLAASLSFSL 131

  Rat   140 ATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWV 204
            ..:||.|||:|||||.|..||||....|::..|::||.|.|:||||||:.||::|.::|....:.
  Fly   132 QMVLYMGIVVYAPALALEAVTGLSQVFSIVIVGVVCTFYATLGGMKAVLITDIYQSLLMFAAVFS 196

  Rat   205 ILARGVILLGGPRNMLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRY 269
            ::....:..|....:..:||.:.||||.:|..||..|:|::|.|:||...:|::|||||.||||.
  Fly   197 VIICAWVKAGSLEVIWRVAQENGRINLTNFSVDPTERHTWFTQILGGCATYLAIYGVNQTQVQRL 261

  Rat   270 VACHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFE 334
            :|..:...|:.||......|.|:..|....|:.::.||:||||||.||:::.||.|||.|:|...
  Fly   262 MAVKSLSAARAALWWCLPILCLLSLSTCFSGLCIYWYYRDCDPLLEGRVNSRDQVMPLFVVDTMG 326

  Rat   335 DLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKL-----VFISKGLSFIY 394
            :..|:.|||::..:..:|||.|:.|:::||||:||.:||.:...|.|.|     ::.||.||..:
  Fly   327 EYTGLAGLFVSGIFCASLSTISSIISSLAAVTLEDYLKPLVSCCAKRTLTDRQTLWYSKLLSLFF 391

  Rat   395 GSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWV 459
            |:.|:.:|.::..: ||:||.:.::.|:|.|||||.|||||.:...|..|.:.||...||...|:
  Fly   392 GALCIGMAFMAGSI-GGLLQAALSIFGIIGGPLLGLFTLGMYVTKANEKGAIGGLLISLAFCFWI 455

  Rat   460 AVGATLYPPGEQTMGVLPTSAAGCTNDSVLLGPPGATNASNGIPSSGMDTGRPALADTF------ 518
            ..|.. .||    :..|..|.|||..|                        |....|.|
  Fly   456 GFGQP-KPP----LVSLDMSTAGCPVD------------------------RSFARDIFLKTVIA 491

  Rat   519 ----------YAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKE 573
                      |.|||::|.|||.|.|...|.|:|:|.          .||.||..|:....|
  Fly   492 VAEEEHYFYLYRISYMWYAALGFLITFFGGWLLSWLF----------ALLKWDNNRRIYQDA--- 543

  Rat   574 DTATLEESLVKGPEDIPAVTKK 595
                 :.:|:|....:|.:.|:
  Fly   544 -----DCTLIKHDLFVPPIAKR 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a5	NP_443215.2	SLC5sbd_NIS	15..549	CDD:271393	207/554 (37%)
Slc5a5	NP_443215.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..618		2/9 (22%)
CG32669	NP_727460.1	SLC5sbd_NIS-SMVT	7..527	CDD:271383	206/549 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	371	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1652
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	1	1.000	-	-		mtm9146
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870