DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc5a5 and CG31262

DIOPT Version :9

Sequence 1:	NP_443215.2	Gene:	Slc5a5 / 114613	RGDID:	69267	Length:	618	Species:	Rattus norvegicus
Sequence 2:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	164/569 - (28%)
Similarity:	274/569 - (48%)	Gaps:	45/569 - (7%)

- Green bases have known domain annotations that are detailed below.

  Rat    12 FGAWDYGVFATMLLVSTGIGLWVGLARG-----------------GQRSADDFFTGGRQLAAVPV 59
            ||..||.|...|.|:|||.|::.|..:.                 |....|::..|.|.:..:||
  Fly     6 FGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMGSRNMKVIPV 70

  Rat    60 GLSLAASFMSAVQVLGVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELR 124
            .::|    .....::|.|:|...||.::..:....:|..:..::::||::..|.:.|.|:||.||
  Fly    71 SITL----YRVTSIIGTPSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQIGSAYEYLGLR 131

  Rat   125 FSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVW 189
            |:..:|...:..|:...:.|...::|.|||.|:||:||:.....|...:.|..||.:||:||||.
  Fly   132 FNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVIILACVTYTFMGGLKAVVH 196

  Rat   190 TDVFQVVVMLVGFWVILARGVILLGGPRNMLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTLV 254
            |||:||.||.:....:....:....|...:...|:...|:.|.:.:|.|..|:|.|:.::||...
  Fly   197 TDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPSPYVRHTVWSVLIGGFSF 261

  Rat   255 WLSMYGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACC--GIVMFVYYKDCDPLLTGR 317
            |.|:....|..||||::..:..|::.|..:..:|:.:.:  |.||  |:::|..||||||...|.
  Fly   262 WTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFI--ALCCFMGLLLFSKYKDCDPRSAGM 324

  Rat   318 ISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKP--RMPGLAP 380
            |...||.:||.|:.....:.|:||||:|..:...||:.|:..|.::.|.:||:::.  :|.....
  Fly   325 ILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRGFFKMEPSER 389

  Rat   381 RKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGV 445
            :..:.|...:.|....|.|.|..|..|  .|:|....::..:.:|...|.||||||.|..||.|.
  Fly   390 QSTILIKTCIIFQGILAFLIVFLLQHL--RGILSVCNSISSITAGTSFGVFTLGMLFPWANTIGT 452

  Rat   446 LSGLAAGLAVSLWVAVGATL-YPPGEQTMGVLPTSAAGCTNDSVLLGPPGATNASNGIPSSGMDT 509
            ..|..:.:.::.|::.|:.: ...|:...|:||.|...|..:..|...|..          ..|.
  Fly   453 AVGGLSSVLLAGWISFGSQIAAASGQLKSGMLPVSVKECVGNVTLPEDPWV----------DQDQ 507

  Rat   510 GRPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLL 558
            ..|     .|.:||.:...:|.:|.::.|||:|.:|.|....:|...|:
  Fly   508 VFP-----LYRLSYHWVSPIGVVTAVVVGALVSLITKPADIKTLHAELI 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a5	NP_443215.2	SLC5sbd_NIS	15..549	CDD:271393	160/555 (29%)
Slc5a5	NP_443215.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..618
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	152/535 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340206
Domainoid	1	1.000	44	1.000	Domainoid score	I11950
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.850