DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CHRNE and nAChRalpha6

DIOPT Version :9

Sequence 1:NP_000071.1 Gene:CHRNE / 1145 HGNCID:1966 Length:493 Species:Homo sapiens
Sequence 2:NP_995675.1 Gene:nAChRalpha6 / 34304 FlyBaseID:FBgn0032151 Length:523 Species:Drosophila melanogaster


Alignment Length:514 Identity:146/514 - (28%)
Similarity:253/514 - (49%) Gaps:76/514 - (14%)


- Green bases have known domain annotations that are detailed below.


Human     8 VLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTT 72
            :|:.|.::........|.||.:||.:.|:...|||....:.:.:...:||..:|.::||.:.|||
  Fly    14 LLIFLAIIKESCQGPHEKRLLNHLLSTYNTLERPVANESEPLEVKFGLTLQQIIDVDEKNQILTT 78

Human    73 SVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVT 137
            :.|:.::|.||.|.:::.::||::.||:....:|.|::::.|:.|..|...|..|::|...||..
  Fly    79 NAWLNLEWNDYNLRWNETEYGGVKDLRITPNKLWKPDVLMYNSADEGFDGTYHTNIVVKHNGSCL 143

Human   138 WLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTEN 202
            ::||.|::|.|.:::|:||||.|:|.:.|.|.||:..:::.....::.|        |...:..|
  Fly   144 YVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVLNSEDGG--------DLSDFITN 200

Human   203 GEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQ 267
            |||.:...||............| ..|:.:::.|||:.|:|..|:||||||||.:.||.:.||..
  Fly   201 GEWYLLAMPGKKNTIVYACCPEP-YVDITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPPD 264

Human   268 AGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLG-----RFLIFVMVVATLI--------- 318
            : |:|.|:.:.:||:.||||.|:|:.:|.||.:|||:|     ...:|:.:||..:         
  Fly   265 S-GEKLTLGVTILLSLTVFLNLVAESMPTTSDAVPLIGVTILLSLTVFLNLVAETLPQVSDAIPL 328

Human   319 ---VMNC------------VIVLNVSQRTPTTHAMSPRLRHVLLELLPRLLGSPPPPEAPRAASP 368
               ..||            |:|||...||...|.|.|.::.|.|:.||.:|         |...|
  Fly   329 LGTYFNCIMFMVASSVVLTVVVLNYHHRTADIHEMPPWIKSVFLQWLPWIL---------RMGRP 384

Human   369 PRRASSVGLLL--RAEELILKKPRSELVF-------EGQRHR-QGTWT-----AAFCQ------- 411
            .|:.:...:||  |.:||.||:..|:.:.       :..||. .|:.|     |:|.:       
  Fly   385 GRKITRKTILLSNRMKELELKERSSKSLLANVLDIDDDFRHTISGSQTAIGSSASFGRPTTVEEH 449

Human   412 --SLGAAAPEVRCCVDAVNFVAESTRDQEATGEEVSDWVRMGNALDNICFWAALVLFSV 468
              ::|....::...:..:.|:....|..:...|.:.||......:|..|    |::|::
  Fly   450 HTAIGCNHKDLHLILKELQFITARMRKADDEAELIGDWKFAAMVVDRFC----LIVFTL 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHRNENP_000071.1 LIC 21..475 CDD:273305 144/501 (29%)
Neur_chan_LBD 24..240 CDD:280998 65/215 (30%)
Neur_chan_memb 247..474 CDD:280999 76/275 (28%)
nAChRalpha6NP_995675.1 LIC 11..517 CDD:273305 146/514 (28%)
LGIC_ECD_nAChR 55..236 CDD:349798 55/189 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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