DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cacna1f and para

DIOPT Version :9

Sequence 1:NP_446153.2 Gene:Cacna1f / 114493 RGDID:621535 Length:1980 Species:Rattus norvegicus
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2116 Identity:501/2116 - (23%)
Similarity:856/2116 - (40%) Gaps:610/2116 - (28%)


- Green bases have known domain annotations that are detailed below.


  Rat     8 KDTTPEPSPANGTG-PGPEWGLCPGPPTVGTDTSGASGLGTPRRRTQ--HNKHKTVVVASAQR-- 67
            :|..|:|.|....| |.|.......||.:.:         ||.....  ::...|.||.|..:  
  Fly    69 EDEGPQPDPTLEQGVPIPVRLQGSFPPELAS---------TPLEDIDPYYSNVLTFVVVSKGKDI 124

  Rat    68 ----SPRALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLE 128
                :.:|::.|...|||||..|.|:....|.:.|:.||..||:.:  .:|        ....:|
  Fly   125 FRFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILM--IMP--------TTPTVE 179

  Rat   129 QVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHT 193
            ..|.:|..|:|.|:.:|::|.|.:|.|..|:|:.||.|||:::.:...::.::.|          
  Fly   180 STEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLG---------- 234

  Rat   194 GGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLEL 258
                   ::.|||.|||||.|:.|:.||.|..::.::::::..|..:.:|.:|.:.::|::||::
  Fly   235 -------NLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQI 292

  Rat   259 FLGRMHKTC--------------------YFLGSDMEAEEDPS---P-CAS-SGSGRSCTLNQTE 298
            ::|.:.:.|                    :...|.....||..   | |.: ||:|: |..:...
  Fly   293 YMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNISGAGQ-CDDDYVC 356

  Rat   299 CRGRWPGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPW--VYFVSLVIFGSF 361
            .:|..|.||.|.|:||:|.:|.|:.|:.:|.:.|.|:...:..|.|   ||  ::|:.::..|||
  Fly   357 LQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG---PWHMLFFIVIIFLGSF 418

  Rat   362 FVLNLVLGVLSGEFSKEREKAKAR--GDFQKLREKQQ--------MEEDLRGYLDWITQ---AEE 413
            :::||:|.:::..:.:.::||:..  .:.:.:||.::        :||...........   |||
  Fly   419 YLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEE 483

  Rat   414 LDLHDP----------------------------------------------------------- 419
            ..||..                                                           
  Fly   484 AALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATK 548

  Rat   420 ---------SVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRW---------------------- 453
                     |:.|:..::....|:.|:..:      |.||.|:                      
  Fly   549 VRKVSTTSLSLPGSPFNIRRGSRSSHKYTI------RNGRGRFGIPGSDRKPLVLSTYQDAQQHL 607

  Rat   454 -----------------------------FSHSTRSTH----STSSHASL--------------- 470
                                         ..||:.::|    |.:||..|               
  Fly   608 PYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKE 672

  Rat   471 ---------------------------------------PASDTGSIT--DTPGDEDEEEGTMAS 494
                                                   ...:.|.|.  |.|..|..:..|:..
  Fly   673 SKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVD 737

  Rat   495 C--TLCLNKIMKTKVCRHFRRANRGL-----------------RARCRRAVKSNA-------CYW 533
            .  .:.||.|::....||.|.::||:                 :.:....:....       |.|
  Fly   738 MKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCW 802

  Rat   534 A-------VLLLVF-------------LNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLL 578
            .       |.|:||             :||:.:|.:||.....:.:..:..|......|.:|..:
  Fly   803 VWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATM 867

  Rat   579 KLYGLGPSVYVASFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLS 643
            ||..:.|..|....:|.||..:|.     .:|:|:|.....|:||||..||||:||:.:.|.:|:
  Fly   868 KLMAMSPKYYFQEGWNIFDFIIVA-----LSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLN 927

  Rat   644 NLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN-----FDQTHTKRSTFDTFPQALLT 703
            .|::.:..:|.::.:|..:|.:.|.||:::||||||..::     |......|..|..|..:.:.
  Fly   928 LLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMI 992

  Rat   704 VFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCV-YFIILFICGNYILLNVFLAIAVDNLASGD-- 765
            ||::|.|| |...|:|.:       :.|.:.|: :|:...:.||.::||:|||:.:.|..|..  
  Fly   993 VFRVLCGE-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLS 1049

  Rat   766 -----------AGAAKDKGREKS-------------------------------------SEG-- 780
                       |.|....||.||                                     |||  
  Fly  1050 APTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKG 1114

  Rat   781 -------------------------------------------------------NPPQENKVLV 790
                                                                   |.|:::|.| 
  Fly  1115 VCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYL- 1178

  Rat   791 PGGENEDTEGTKS--------------EGAAPGMEEEEEEE--------EEEEEENGA------- 826
            ....::||....|              :|:|..||.||:.:        :||.:|.|.       
  Fly  1179 NNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEELDEEGECEEGPLD 1243

  Rat   827 ------GHVELLQEVVPKE-------KVVPIPEG---SAFFCLSQTNPLRKACHTLIHHHVFTSL 875
                  .|.|.:.:..|.:       |..||..|   |.|:  .....||.....||.:..|.:.
  Fly  1244 GDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFW--QGWGNLRLKTFQLIENKYFETA 1306

  Rat   876 ILVFIILSSVSLAAED---PIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRS 937
            ::..|::||::||.||   |.|  .....||.|.|..||.||.:|:|:|....|..::   |..:
  Fly  1307 VITMILMSSLALALEDVHLPQR--PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVY---FTNA 1366

  Rat   938 WFNLLDLLVVSVSLISFG---IHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 999
            |. .||.::|.||||:|.   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|
  Fly  1367 WC-WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSI 1430

  Rat  1000 GNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLVRERLWVNS 1064
            .|:::|..:...:||.:|||||.||::.|.|     :...|.|..|.|:.:....  ....||||
  Fly  1431 FNVLLVCLIFWLIFAIMGVQLFAGKYFKCED-----MNGTKLSHEIIPNRNACES--ENYTWVNS 1488

  Rat  1065 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYIIIIAFFMMN 1129
            ..|||:|.:|.:.||.|:||:||..::..|||:...|:.||...::.:.::|:.:||..:||.:|
  Fly  1489 AMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLN 1553

  Rat  1130 IFVGFVIITFRAQGEQEYQNCELDKNQRQCVEY----------ALKAQPLRRYIPKNPHQYRVWA 1184
            :|:|.:|..|..|.::...:.|:...:.|...|          .|||.|..|:.|    |..|:.
  Fly  1554 LFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----QAIVFE 1614

  Rat  1185 TVNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYF 1249
            .|....|:.::.|.|.||...:.:..|:.:..:|..:|.||.:|..:|:.|.:|||.|.: .|||
  Fly  1615 IVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR-YHYF 1678

  Rat  1250 ADAWNTFDALIVVGSVVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVM---RLVKLLSKGEG 1311
            .:.||.||.::|:.|::.:.::::          .:...:|.|..|:.||.   |:::|:...:|
  Fly  1679 IEPWNLFDVVVVILSILGLVLSDI----------IEKYFVSPTLLRVVRVAKVGRVLRLVKGAKG 1733

  Rat  1312 IRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLF 1376
            |||||:....|..||..:.||:.::.||:|:.||..|..|..:.|  ||...||:||.|:::|||
  Fly  1734 IRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFGQSMILLF 1796

  Rat  1377 RCATGEAWQEIMLASLPGNRCD-PESDFG-PGEEFTCGS-NFAIVYFISFFMLCAFLIINLFVAV 1438
            :.:|...|..::.|.:....|| |::|.| ||   .||| ...|.:.:|:.::...::||:::||
  Fly  1797 QMSTSAGWDGVLDAIINEEACDPPDNDKGYPG---NCGSATVGITFLLSYLVISFLIVINMYIAV 1858

  Rat  1439 IMDNFDYLTRD-WSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRV 1502
            |::|:...|.| ...|.....|.:..||.::||.....|::..:...|..::|||...|  |::.
  Fly  1859 ILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK--PNKY 1921

  Rat  1503 ACKRLVAMNVPLNSDGTVTFNATLFALVRTSLRIKTEGNLDQANQELRMVIKKIWKRIKQKLLDE 1567
               ::::|::|:.....:.....|.||.:.....|  ||..:...|                :.|
  Fly  1922 ---KIISMDIPICRGDLMYCVDILDALTKDFFARK--GNPIEETGE----------------IGE 1965

  Rat  1568 VIPPPDEE-----EVTVGK---FYATFLIQDYFRKFRRRKEKGLLGADAPTSTSSVLQAGLRSLQ 1624
            :...||.|     ..|:.:   .|...|||..:||.:.|.|.|  |:..|               
  Fly  1966 IAARPDTEGYEPVSSTLWRQREEYCARLIQHAWRKHKARGEGG--GSFEP--------------- 2013

  Rat  1625 DLGPEIRQALTYDTEEEEEEEEAAGQEAEEEEAENN 1660
                        ||:..:..:..||..|.:|..:.:
  Fly  2014 ------------DTDHGDGGDPDAGDPAPDEATDGD 2037

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cacna1fNP_446153.2 Ion_trans 91..383 CDD:395416 83/318 (26%)
Ion_trans 532..763 CDD:395416 73/256 (29%)
Ion_trans 869..1106 CDD:395416 88/242 (36%)
Ion_trans 1188..1451 CDD:395416 85/269 (32%)
GPHH 1460..1513 CDD:407139 12/52 (23%)
Ca_chan_IQ 1524..1595 CDD:400901 17/78 (22%)
CAC1F_C 1618..1977 CDD:407123 6/43 (14%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 78/301 (26%)
Na_trans_cytopl 515..648 CDD:288761 11/138 (8%)
Ion_trans 835..1028 CDD:278921 58/205 (28%)
Na_trans_assoc 1054..1296 CDD:284034 37/244 (15%)
Ion_trans 1318..1571 CDD:278921 96/265 (36%)
Na_channel_gate 1561..1613 CDD:240441 12/55 (22%)
Ion_trans 1636..1871 CDD:278921 80/250 (32%)
GPHH 1880..1930 CDD:293510 13/54 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.