Protein Alignment Chrng and nAChRbeta1

DIOPT Version :10

• Sequence 1: XP_006529141.1
• Gene: Chrng / 11449
• MGIID: 87895
• Length: 541
• Species: Mus musculus
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 504
• Identity: 172/504 - (34%)
• Similarity: 262/504 - (51%)
• Gaps: 61/504 - (12%)

Mouse    48 EERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWD 112
            ||||:.||.|.|:..:||.:..:..|.|...|....||::||:.:.:.:|||:.:.|.||:|:||
  Fly    28 EERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWD 92

Mouse   113 PKDYEGLWILRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSSCSISVT 177
            ..||.|:.:||:|...||:|||||.||.||.:||....|||:.|.|.:.|:||||::|||:|.||
  Fly    93 EADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVT 157

Mouse   178 YFPFDWQNCSLVFQSQTYSTSEINLQLSQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKMLL--- 239
            |||||.|.|.:.|.|.|::..:::|.|.....      |:|...:.::|.|.|...||.:.:
  Fly   158 YFPFDQQTCIMKFGSWTFNGDQVSLALYNNKN------FVDLSDYWKSGTWDIIEVPAYLNVYEG 216

Mouse   240 DSVAPAEEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTVATNVLL 304
            ||..|.|    ..:.||::|:||.|||.:|:|.|.||||.:.:|:::|||:| |:|.|:..::||
  Fly   217 DSNHPTE----TDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAEA-GEKVTLGISILL 276

Mouse   305 AQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSMARGVRKVF 369
            :..|||.||:|.:|.||..:|||:|||.|..::..:.::.:|:::|.:.|.|.||.|...:|.:|
  Fly   277 SLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRTHRMPMYIRSIF 341

Mouse   370 LRLLPQLLRM---------------------HVRPL--APAAVQDARFRLQNGSSSGWPIMAREE 411
            |..||..|.|                     |..|.  :||.: ........|..|...:|  |.
  Fly   342 LHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAEL-PKHISAIGGKQSKMEVM--EL 403

Mouse   412 GDLCLPRSELLFRQRQRNGLVQAVLEKLENGPEV------RQSQEFCGSLKQASPAIQACVDACN 470
            .||..|..:              :..|:.:|.|:      |:..|...|: ..||......:|..
  Fly   404 SDLHHPNCK--------------INRKVNSGGELGLGDGCRRESESSDSI-LLSPEASKATEAVE 453

Mouse   471 LMARARRQQSHFDSGNEEWLLVGRVLDRVCFLAMLSLFICGTAGIFLMA 519
            .:|...|.:..:....|:|..|..|:||:.......:...||.||.:.|
  Fly   454 FIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDA 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chrng	XP_006529141.1	LGIC_ECD_nAChR_G	71..263	CDD:349830	78/194 (40%)
		Cys-loop	172..186	CDD:349830	10/13 (77%)
		Neur_chan_memb	270..516	CDD:460753	77/274 (28%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	171/500 (34%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	88/217 (41%)
		Cys-loop	152..166	CDD:349833	10/13 (77%)