DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Slc5a5 and CG31262

DIOPT Version :9

Sequence 1:	NP_444478.2	Gene:	Slc5a5 / 114479	MGIID:	2149330	Length:	618	Species:	Mus musculus
Sequence 2:	NP_001138069.2	Gene:	CG31262 / 318649	FlyBaseID:	FBgn0051262	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	166/575 - (28%)
Similarity:	275/575 - (47%)	Gaps:	57/575 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse    12 FGPWDYGVFATMLLVSTGIGLWVGLARG-----------------GQRSADDFFTGGRQLAAVPV 59
            ||..||.|...|.|:|||.|::.|..:.                 |....|::..|.|.:..:||
  Fly     6 FGTVDYLVLVAMTLLSTGTGIYFGALKKKHKNKKSVSEDNRRTNFGSEKIDEYLMGSRNMKVIPV 70

Mouse    60 GLSLAASFMSAVQVLGVPAEAARYGLKFLWMCVGQLLNSLLTALLFLPIFYRLGLTSTYQYLELR 124
            .::|    .....::|.|:|...||.::..:.|..:|..:..:.::||::..|.:.|.|:||.||
  Fly    71 SITL----YRVTSIIGTPSEIYHYGTQYYLIIVAIILQGIAFSYVYLPVYSALQIGSAYEYLGLR 131

Mouse   125 FSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVW 189
            |:..:|...:..|:...:.|...::|.|||.|:||:||:.....|...:.|..||.:||:||||.
  Fly   132 FNSIIRTTASFMYVFGILTYLPFIVYVPALSLSQVSGLNTHLIGLVIILACVTYTFMGGLKAVVH 196

Mouse   190 TDVFQVVVMLVGFWVILARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGGSLV 254
            |||:||.||.:....:....:....|...|...|:...|:.|.:.:|.|..|:|.|:.::||...
  Fly   197 TDVWQVAVMFLSLVAVAFLAIYYSNGLVAVFDDAEQGGRLMLANTNPSPYVRHTVWSVLIGGFSF 261

Mouse   255 WLSMYGVNQAQVQRYVACHTERKAKLALLVNQLGLFLIVASAACC--GIVMFVYYKDCDPLLTGR 317
            |.|:....|..||||::..:.:|::.|..:..:|:.:.:  |.||  |:::|..||||||...|.
  Fly   262 WTSVNAGGQHMVQRYMSLPSLKKSRQASFIFTIGVSIFI--ALCCFMGLLLFSKYKDCDPRSAGM 324

Mouse   318 IAAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIK--------PR 374
            |...||.:||.|:.....:.|:||||:|..:...||:.|:..|.::.|.:||:::        .|
  Fly   325 ILNDDQLLPLFVVQSVGHIYGMPGLFIAGIFGAGLSSLSSCFNTVSMVFLEDIVRGFFKMEPSER 389

Mouse   375 MPSLAPRKLVFISKGLSFIYGSTCLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPA 439
            ..::..:..:.....|:|      |.|..|..|  .|:|....::..:.:|...|.||||||.|.
  Fly   390 QSTILIKTCIIFQGILAF------LIVFLLQHL--RGILSVCNSISSITAGTSFGVFTLGMLFPW 446

Mouse   440 CNTPGVLSGLTAGLAVSLWVAVGATL-YPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIP 503
            .||.|...|..:.:.::.|::.|:.: ...|:...|:||.|...|.....||..|..
  Fly   447 ANTIGTAVGGLSSVLLAGWISFGSQIAAASGQLKSGMLPVSVKECVGNVTLPEDPWV-------- 503

Mouse   504 SSGMDSGRPAFADTFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLL 558
              ..|...|     .|.:||.:...:|.:|.::.|||:|.:|.|....:|...|:
  Fly   504 --DQDQVFP-----LYRLSYHWVSPIGVVTAVVVGALVSLITKPADIKTLHAELI 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Slc5a5	NP_444478.2	SLC5sbd_NIS	15..549	CDD:271393	162/561 (29%)
Slc5a5	NP_444478.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	571..618
CG31262	NP_001138069.2	SLC5sbd_NIS-SMVT	9..522	CDD:271383	154/541 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836523
Domainoid	1	1.000	46	1.000	Domainoid score	I12033
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850