DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ncam2 and DIP-epsilon

DIOPT Version :9

Sequence 1:	NP_571905.1	Gene:	ncam2 / 114441	ZFINID:	ZDB-GENE-010822-1	Length:	795	Species:	Danio rerio
Sequence 2:	NP_001137799.1	Gene:	DIP-epsilon / 7354433	FlyBaseID:	FBgn0259714	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	85/356 - (23%)
Similarity:	148/356 - (41%)	Gaps:	69/356 - (19%)

- Green bases have known domain annotations that are detailed below.

Zfish    13 VGGSQGALQVSIS--------LKKVELSVGESKFFTCTV--IGEPVKLEWFNPQGERMVA----- 62
            ||||  .|...||        ::.:.:..|.:....|:|  :|. .|:.|.:.:...::.
  Fly    39 VGGS--TLNNVISEDPEFTDVIENITVPAGRNVKLACSVKNLGS-YKVAWMHFEQSAILTVHNHV 100

Zfish    63 ---SPRVAL-HNEGIRSR---LTLYNAKIEDAGIYRCQATDAQGETQ----EATVVLEIYQKLTF 116
               :||::: |::..:.|   |.:.|.:.||.|.|.||......:||    :..|...|...||.
  Fly   101 ITRNPRISVTHDKHDKHRTWFLHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTS 165

Zfish   117 RDVRSPQEFRQGEVAEVVCDVTSSPVPVVSWFY---NNIEITEDTEKFELLQNNNLQVQKVTKAD 178
            .|:    ..|:|:...:.|....||.|.:.|..   |.|.|.:..|..: |:.::|:::::::..
  Fly   166 SDI----IVREGDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHD-LETDSLELERISRLH 225

Zfish   179 EGVYRCEARVEARGEIDFRNIILVVNVPPVVSVPQQSFNATADYGESVTFTCRAYGSPEPDVTWH 243
            .|.|.|.|.......:. :.|.:.|:..|:|.:|.|...  ...|.::|..|....:|.....|.
  Fly   226 MGAYLCIASNGVPPSVS-KRIKVSVDFSPMVWIPHQLVG--IPIGFNITLECFIEANPTSLNYWT 287

Zfish   244 RKGVQ-LQESERY-------------VMRARGTTLTVRNIQQDDGGSYTCRASNKAGEVEHELFL 294
            |:..| :.||.:|             .||     ||:.|:|..|.|:|.|.|.|..|:::..  :
  Fly   288 RENDQMITESSKYKTETIPGHPSYKATMR-----LTITNVQSSDYGNYKCVAKNPRGDMDGN--I 345

Zfish   295 KVFVQ--------PHITKLRNVTAVEGSAAM 317
            |:::.        |..|.||..|......|:
  Fly   346 KLYMSSPPTTQPPPTTTTLRRTTTTAAEIAL 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ncam2	NP_571905.1	Ig1_NCAM-2	20..111	CDD:143274	24/116 (21%)
		I-set	21..110	CDD:254352	23/114 (20%)
		IGc2	127..187	CDD:197706	15/62 (24%)
		Ig	213..299	CDD:299845	25/99 (25%)
		I-set	213..296	CDD:254352	24/96 (25%)
		Ig	298..395	CDD:299845	6/28 (21%)
		I-set	300..393	CDD:254352	6/18 (33%)
		IG_like	411..488	CDD:214653
		IGc2	412..480	CDD:197706
		FN3	494..586	CDD:238020
		fn3	<616..675	CDD:278470
DIP-epsilon	NP_001137799.1	IG_like	59..155	CDD:214653	20/96 (21%)
		Ig	69..139	CDD:143165	16/70 (23%)
		IG_like	165..249	CDD:214653	19/89 (21%)
		IGc2	172..237	CDD:197706	16/65 (25%)
		IG_like	267..348	CDD:214653	24/87 (28%)
		Ig	270..339	CDD:299845	21/73 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010