Protein Alignment Chrna7 and nAChRbeta1

DIOPT Version :10

• Sequence 1: NP_031416.3
• Gene: Chrna7 / 11441
• MGIID: 99779
• Length: 502
• Species: Mus musculus
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 536
• Identity: 197/536 - (36%)
• Similarity: 304/536 - (56%)
• Gaps: 75/536 - (13%)

Mouse     9 WLALAAALLHVSLQ----GEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKN 69
            || |.:.|:.|:..    .|.:.||.::|.:.||.|.|||.|.:|.:.|.|.|:.:|:::|:|||
  Fly     8 WL-LCSILVLVAFSLVSASEDEERLVRDLFRGYNKLIRPVQNMTQKVGVRFGLAFVQLINVNEKN 71

Mouse    70 QVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNA 134
            |::.:|:||::.|.|:.|||:.::|.|:..:|.|..::|||||:|:|:||..::..:.:|||:..
  Fly    72 QIMKSNVWLRLVWYDYQLQWDEADYGGIGVLRLPPDKVWKPDIVLFNNADGNYEVRYKSNVLIYP 136

Mouse   135 SGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQE----ADISSYIPNGE 195
            :|...::||.|::|||.|||.:||||.|.|.:|||||::.|..:.|.:..    .|:|.|..:|.
  Fly   137 TGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLALYNNKNFVDLSDYWKSGT 201

Mouse   196 WDLMGIPGKRNEKFYECCKEPYP---DVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPAD 257
            ||::.:|...|  .|| ....:|   |:|:.:.:||:||:|.:||::|.||||.|.:|||.|||:
  Fly   202 WDIIEVPAYLN--VYE-GDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPAE 263

Mouse   258 SGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDP 322
            :|||::|||::||||.||:|||::|:|.||..:||||:|...|.|:..:|::||||::.::...|
  Fly   264 AGEKVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGP 328

Mouse   323 DGGKMPKWTRIILLNWCAWFLRMKRPGEDKVR----------PACQHK--------PRRCS---- 365
            ...:||.:.|.|.|::...||.||||.:.::|          ||..|.        |:..|
  Fly   329 RTHRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKHISAIGG 393

Mouse   366 ----LASVELSAGAGP-------PTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEH 419
                :..:|||....|       ..|.|.|      ||           |..|.|.  |.:.|..
  Fly   394 KQSKMEVMELSDLHHPNCKINRKVNSGGEL------GL-----------GDGCRRE--SESSDSI 439

Mouse   420 LMHGTHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTI 484
            |:        .|:.:|..|.|.:||...|.:|.......:||:.|.|:|||.|..|.:.|...|:
  Fly   440 LL--------SPEASKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIFFIVTTAGTV 496

Mouse   485 GILMSAPNFVEAVSKD 500
            ||||.||:..|.|.:|
  Fly   497 GILMDAPHIFEYVDQD 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chrna7	NP_031416.3	LIC	4..490	CDD:273305	192/524 (37%)
		Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000269|PubMed:32783947	260..267		4/6 (67%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:455710	190/522 (36%)
		LGIC_ECD_nAChR_proto_beta-like	27..236	CDD:349833	82/211 (39%)
		Cys-loop	152..166	CDD:349833	9/13 (69%)